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Cost and clinical outcome of islet transplantation in Norway 2010-2015

Schive, Simen W.; Foss, Aksel; Sahraoui, Afaf; Kloster-Jensen, Kristine; Hafsahl, Geir; Kvalheim, Gunnar; Lundgren, Torbjørn; von Zur-Mühlen, Bengt; Felldin, Marie and Rafael, Ehab LU , et al. (2017) In Clinical Transplantation 31(1).
Abstract

Islet transplantation is a minimally invasive β-cell replacement strategy. Islet transplantation is a reimbursed treatment in Norway. Here, we summarize the cost and clinical outcome of 31 islet transplantations performed at Oslo University Hospital (OUS) from January 2010 to June 2015. Patients were retrospectively divided into three groups. Thirteen patients received either one or two islet transplantation alone (ITA), while five patients received islet transplantation after previous solid organ transplantation. For the group receiving 2 ITA, Kaplan-Meier estimates show an insulin independence of 20% more than 4 years after their last transplantation. An estimated 70% maintain at least partial graft function, defined as fasting... (More)

Islet transplantation is a minimally invasive β-cell replacement strategy. Islet transplantation is a reimbursed treatment in Norway. Here, we summarize the cost and clinical outcome of 31 islet transplantations performed at Oslo University Hospital (OUS) from January 2010 to June 2015. Patients were retrospectively divided into three groups. Thirteen patients received either one or two islet transplantation alone (ITA), while five patients received islet transplantation after previous solid organ transplantation. For the group receiving 2 ITA, Kaplan-Meier estimates show an insulin independence of 20% more than 4 years after their last transplantation. An estimated 70% maintain at least partial graft function, defined as fasting C-peptide >0.1 nmol L−1, and 47% maintain a HbA1c below 6.5% or 2 percent points lower than before ITA. For all groups combined, we estimate that 44% of the patients have a 50% reduction in insulin requirement 4 years after the initial islet transplantation. The average cost for an islet transplantation procedure was 347 297±60 588 NOK, or 35 424±6182 EUR, of which isolation expenses represent 34%. We hereby add to the common pool of growing experience with islet transplantation and also describe the cost of the treatment at our center.

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publication status
published
subject
keywords
cost, islet transplantation, outcome, type 1 diabetes
in
Clinical Transplantation
volume
31
issue
1
publisher
Wiley-Blackwell
external identifiers
  • scopus:85006511362
  • wos:000392436100011
ISSN
0902-0063
DOI
10.1111/ctr.12871
language
English
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yes
id
4bc73d87-e463-4daf-8534-3032bbd37e50
date added to LUP
2017-01-16 10:33:08
date last changed
2018-01-07 11:45:10
@article{4bc73d87-e463-4daf-8534-3032bbd37e50,
  abstract     = {<p>Islet transplantation is a minimally invasive β-cell replacement strategy. Islet transplantation is a reimbursed treatment in Norway. Here, we summarize the cost and clinical outcome of 31 islet transplantations performed at Oslo University Hospital (OUS) from January 2010 to June 2015. Patients were retrospectively divided into three groups. Thirteen patients received either one or two islet transplantation alone (ITA), while five patients received islet transplantation after previous solid organ transplantation. For the group receiving 2 ITA, Kaplan-Meier estimates show an insulin independence of 20% more than 4 years after their last transplantation. An estimated 70% maintain at least partial graft function, defined as fasting C-peptide &gt;0.1 nmol L<sup>−1</sup>, and 47% maintain a HbA1c below 6.5% or 2 percent points lower than before ITA. For all groups combined, we estimate that 44% of the patients have a 50% reduction in insulin requirement 4 years after the initial islet transplantation. The average cost for an islet transplantation procedure was 347 297±60 588 NOK, or 35 424±6182 EUR, of which isolation expenses represent 34%. We hereby add to the common pool of growing experience with islet transplantation and also describe the cost of the treatment at our center.</p>},
  articleno    = {e12871},
  author       = {Schive, Simen W. and Foss, Aksel and Sahraoui, Afaf and Kloster-Jensen, Kristine and Hafsahl, Geir and Kvalheim, Gunnar and Lundgren, Torbjørn and von Zur-Mühlen, Bengt and Felldin, Marie and Rafael, Ehab and Lempinen, Marko and Korsgren, Olle and Jenssen, Trond G. and Mishra, Vinod and Scholz, Hanne},
  issn         = {0902-0063},
  keyword      = {cost,islet transplantation,outcome,type 1 diabetes},
  language     = {eng},
  month        = {01},
  number       = {1},
  publisher    = {Wiley-Blackwell},
  series       = {Clinical Transplantation},
  title        = {Cost and clinical outcome of islet transplantation in Norway 2010-2015},
  url          = {http://dx.doi.org/10.1111/ctr.12871},
  volume       = {31},
  year         = {2017},
}