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Hypertension in adults with repaired coarctation of the aorta

Rinnström, Daniel; Dellborg, Mikael; Thilén, Ulf LU ; Sörensson, Peder; Nielsen, Niels Erik; Christersson, Christina and Johansson, Bengt (2016) In American Heart Journal 181. p.10-15
Abstract

Aims In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. Methods and results In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9 ± 14.4 years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90 mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an... (More)

Aims In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. Methods and results In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9 ± 14.4 years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90 mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an association with HTN was found at the ranges of (10, 20] and >20 mmHg, in comparison to the interval ≤10 mmHg (OR 3.58, CI 1.70-7.55, and OR 11.38, CI 4.03-32.11). This model remained valid when all patients who had increased BP (≥140/90 mmHg) without having been diagnosed with HTN were excluded from the analyses. Conclusions Hypertension is common in patients with previously repaired CoA and is associated with increasing age, male sex, and elevated body mass index. There is also an association with arm-leg BP gradient, starting at relatively low levels that are usually not considered for intervention.

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type
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publication status
published
subject
in
American Heart Journal
volume
181
pages
6 pages
publisher
Mosby
external identifiers
  • scopus:84984924272
  • wos:000387253900004
ISSN
0002-8703
DOI
10.1016/j.ahj.2016.07.012
language
English
LU publication?
yes
id
4c0dc6c3-377a-4dc8-96aa-10a7c15b49a4
date added to LUP
2016-09-28 16:02:38
date last changed
2017-01-09 12:11:51
@article{4c0dc6c3-377a-4dc8-96aa-10a7c15b49a4,
  abstract     = {<p>Aims In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. Methods and results In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9 ± 14.4 years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90 mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1.07, CI 1.05-1.10), sex (male) (OR 3.35, CI 1.98-5.68), and body mass index (kilograms per square meter) (OR 1.09, CI 1.03-1.16) were independently associated with having HTN, and so was systolic arm-leg BP gradient where an association with HTN was found at the ranges of (10, 20] and &gt;20 mmHg, in comparison to the interval ≤10 mmHg (OR 3.58, CI 1.70-7.55, and OR 11.38, CI 4.03-32.11). This model remained valid when all patients who had increased BP (≥140/90 mmHg) without having been diagnosed with HTN were excluded from the analyses. Conclusions Hypertension is common in patients with previously repaired CoA and is associated with increasing age, male sex, and elevated body mass index. There is also an association with arm-leg BP gradient, starting at relatively low levels that are usually not considered for intervention.</p>},
  author       = {Rinnström, Daniel and Dellborg, Mikael and Thilén, Ulf and Sörensson, Peder and Nielsen, Niels Erik and Christersson, Christina and Johansson, Bengt},
  issn         = {0002-8703},
  language     = {eng},
  month        = {11},
  pages        = {10--15},
  publisher    = {Mosby},
  series       = {American Heart Journal},
  title        = {Hypertension in adults with repaired coarctation of the aorta},
  url          = {http://dx.doi.org/10.1016/j.ahj.2016.07.012},
  volume       = {181},
  year         = {2016},
}