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Influence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man

Olsen, H LU ; Groop, Leif LU and Lanne, T (2003) In European Journal of Applied Physiology 90(1-2). p.138-143
Abstract
This study examined the influence of insulin and glucose on the transcapillary fluid absorption during lower body negative pressure (LBNP) in humans. Ten healthy males [23 (1) years] were exposed to LBNP of 45 cmH(2)O on two occasions: (1) before and during a hyperinsulinaemic clamp (HI) and (2) before and during a hyperglycaemic clamp (HG). Transcapillary fluid absorption and blood flow were recorded with volumetric technique. Forearm blood flow increased during HI from 2.3 (0.3) ml (100 ml)(-1) min(-1) to 3.3 (0.5) ml (100 ml)(-1) min(-1) (P<0.05). The haemodynamic response to LBNP was similar during HI and HG compared with control LBNP. Transcapillary fluid absorption during LBNP increased during HG from 0.044 (0.007) ml (100 ml)(-1)... (More)
This study examined the influence of insulin and glucose on the transcapillary fluid absorption during lower body negative pressure (LBNP) in humans. Ten healthy males [23 (1) years] were exposed to LBNP of 45 cmH(2)O on two occasions: (1) before and during a hyperinsulinaemic clamp (HI) and (2) before and during a hyperglycaemic clamp (HG). Transcapillary fluid absorption and blood flow were recorded with volumetric technique. Forearm blood flow increased during HI from 2.3 (0.3) ml (100 ml)(-1) min(-1) to 3.3 (0.5) ml (100 ml)(-1) min(-1) (P<0.05). The haemodynamic response to LBNP was similar during HI and HG compared with control LBNP. Transcapillary fluid absorption during LBNP increased during HG from 0.044 (0.007) ml (100 ml)(-1) min(-1) to 0.059 (0.009) ml (100 ml)(-1) min(-1) (P<0.01), whereas it was unchanged during HI. In conclusion, hyperglycaemia augments transcapillary fluid absorption from skeletal muscle and skin during LBNP whereas hyperinsulinaemia has no such effect. This indicates that in human hyperglycaemia contributes to plasma volume restitution during hypovolaemic circulatory stress. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hyperinsulinaemia, hyperglycaemia, skeletal muscle, lower body negative pressure, capillary permeability
in
European Journal of Applied Physiology
volume
90
issue
1-2
pages
138 - 143
publisher
Springer
external identifiers
  • wos:000185457700020
  • pmid:12851825
  • scopus:0242551187
ISSN
1439-6327
DOI
10.1007/s00421-003-0894-3
language
English
LU publication?
no
id
4c0f1168-ef90-40e0-95d2-bbd6694a35f7 (old id 899962)
date added to LUP
2008-01-15 09:58:51
date last changed
2019-05-29 09:29:55
@article{4c0f1168-ef90-40e0-95d2-bbd6694a35f7,
  abstract     = {This study examined the influence of insulin and glucose on the transcapillary fluid absorption during lower body negative pressure (LBNP) in humans. Ten healthy males [23 (1) years] were exposed to LBNP of 45 cmH(2)O on two occasions: (1) before and during a hyperinsulinaemic clamp (HI) and (2) before and during a hyperglycaemic clamp (HG). Transcapillary fluid absorption and blood flow were recorded with volumetric technique. Forearm blood flow increased during HI from 2.3 (0.3) ml (100 ml)(-1) min(-1) to 3.3 (0.5) ml (100 ml)(-1) min(-1) (P&lt;0.05). The haemodynamic response to LBNP was similar during HI and HG compared with control LBNP. Transcapillary fluid absorption during LBNP increased during HG from 0.044 (0.007) ml (100 ml)(-1) min(-1) to 0.059 (0.009) ml (100 ml)(-1) min(-1) (P&lt;0.01), whereas it was unchanged during HI. In conclusion, hyperglycaemia augments transcapillary fluid absorption from skeletal muscle and skin during LBNP whereas hyperinsulinaemia has no such effect. This indicates that in human hyperglycaemia contributes to plasma volume restitution during hypovolaemic circulatory stress.},
  author       = {Olsen, H and Groop, Leif and Lanne, T},
  issn         = {1439-6327},
  keyword      = {hyperinsulinaemia,hyperglycaemia,skeletal muscle,lower body negative pressure,capillary permeability},
  language     = {eng},
  number       = {1-2},
  pages        = {138--143},
  publisher    = {Springer},
  series       = {European Journal of Applied Physiology},
  title        = {Influence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man},
  url          = {http://dx.doi.org/10.1007/s00421-003-0894-3},
  volume       = {90},
  year         = {2003},
}