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Molecular subtype profiling of urothelial carcinoma using a subtype-specific immunohistochemistry panel

Sjödahl, Gottfrid LU (2018) In Methods in Molecular Biology 1655. p.53-64
Abstract

Molecular subtypes of bladder cancer (BC) can be determined by relatively small immunohistochemistry panels both for non-muscle invasive (NMI) and muscle invasive (MI) tumors. For analysis of NMI tumors, as few as two markers are needed, although classification is dependent also on pathological grade and histological evaluation. The result is a classification into the three tumor-cell phenotypes of NMI-BC, Urothelial-like (Uro), Genomically Unstable (GU), and Basal/SCC-like. For analysis of MI tumors, 13 markers are needed. The larger number of markers required for the classification of MI-BC reflects the inclusion of two additional phenotypes exclusively found in invasive tumors; Mesenchymal-like (Mes-like) and... (More)

Molecular subtypes of bladder cancer (BC) can be determined by relatively small immunohistochemistry panels both for non-muscle invasive (NMI) and muscle invasive (MI) tumors. For analysis of NMI tumors, as few as two markers are needed, although classification is dependent also on pathological grade and histological evaluation. The result is a classification into the three tumor-cell phenotypes of NMI-BC, Urothelial-like (Uro), Genomically Unstable (GU), and Basal/SCC-like. For analysis of MI tumors, 13 markers are needed. The larger number of markers required for the classification of MI-BC reflects the inclusion of two additional phenotypes exclusively found in invasive tumors; Mesenchymal-like (Mes-like) and Small-cell/Neuroendocrine-like (Sc/NE-like). Here follows a description of how to perform and approach IHC-based subtype classification of bladder cancer.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Basal/SCC-like, Bladder cancer, Classification, Genomically unstable, Mesenchymal-like, Molecular subtypes, Phenotype, Small-cell/neuroendocrine-like, Urothelial carcinoma, Urothelial-like
in
Methods in Molecular Biology
volume
1655
pages
12 pages
publisher
Humana Press
external identifiers
  • scopus:85029383713
ISSN
10643745
DOI
10.1007/978-1-4939-7234-0_5
language
English
LU publication?
yes
id
4c2233e2-43dc-48d2-a130-bfae3216b542
date added to LUP
2017-09-28 14:44:42
date last changed
2017-09-29 03:00:03
@inbook{4c2233e2-43dc-48d2-a130-bfae3216b542,
  abstract     = {<p>Molecular subtypes of bladder cancer (BC) can be determined by relatively small immunohistochemistry panels both for non-muscle invasive (NMI) and muscle invasive (MI) tumors. For analysis of NMI tumors, as few as two markers are needed, although classification is dependent also on pathological grade and histological evaluation. The result is a classification into the three tumor-cell phenotypes of NMI-BC, Urothelial-like (Uro), Genomically Unstable (GU), and Basal/SCC-like. For analysis of MI tumors, 13 markers are needed. The larger number of markers required for the classification of MI-BC reflects the inclusion of two additional phenotypes exclusively found in invasive tumors; Mesenchymal-like (Mes-like) and Small-cell/Neuroendocrine-like (Sc/NE-like). Here follows a description of how to perform and approach IHC-based subtype classification of bladder cancer.</p>},
  author       = {Sjödahl, Gottfrid},
  issn         = {10643745},
  keyword      = {Basal/SCC-like,Bladder cancer,Classification,Genomically unstable,Mesenchymal-like,Molecular subtypes,Phenotype,Small-cell/neuroendocrine-like,Urothelial carcinoma,Urothelial-like},
  language     = {eng},
  pages        = {53--64},
  publisher    = {Humana Press},
  series       = {Methods in Molecular Biology},
  title        = {Molecular subtype profiling of urothelial carcinoma using a subtype-specific immunohistochemistry panel},
  url          = {http://dx.doi.org/10.1007/978-1-4939-7234-0_5},
  volume       = {1655},
  year         = {2018},
}