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Affinity ultrafiltration for protein purification

Kaul, Rajni LU and Mattiasson, Bo LU (1993) p.487-498
Abstract
Purification of a biochemical product from fermentation broths or other complex biological mixtures generally involves a combination of techniques which resolve substances according to differences in their physicochemical properties. These techniques have traditionally been optimized individually rather than as a part of the integrated, continuous process. Moreover, a lot of the development and refinement of the procedures has taken place on a laboratory scale, with little consideration given to the economics of scaling up. As a result, downstream processing presently accounts for a major portion of the processing costs of producing a biotechnological product.
In order to cut down on costs and also to prevent the product loss that... (More)
Purification of a biochemical product from fermentation broths or other complex biological mixtures generally involves a combination of techniques which resolve substances according to differences in their physicochemical properties. These techniques have traditionally been optimized individually rather than as a part of the integrated, continuous process. Moreover, a lot of the development and refinement of the procedures has taken place on a laboratory scale, with little consideration given to the economics of scaling up. As a result, downstream processing presently accounts for a major portion of the processing costs of producing a biotechnological product.
In order to cut down on costs and also to prevent the product loss that occurs during several purification stages, it is critical to design processes that possess high product recovery and resolution from impure feed streams. (Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Molecular Interactions in Bioseparations
editor
Ngo, That T.
pages
487 - 498
publisher
Plenum Press
ISBN
0306444356
DOI
10.1007/978-1-4899-1872-7_32
language
English
LU publication?
yes
id
4c639419-e0bd-41e2-b5bc-999bd42df554
date added to LUP
2019-06-30 09:05:23
date last changed
2020-11-10 09:36:40
@inbook{4c639419-e0bd-41e2-b5bc-999bd42df554,
  abstract     = {{Purification of a biochemical product from fermentation broths or other complex biological mixtures generally involves a combination of techniques which resolve substances according to differences in their physicochemical properties. These techniques have traditionally been optimized individually rather than as a part of the integrated, continuous process. Moreover, a lot of the development and refinement of the procedures has taken place on a laboratory scale, with little consideration given to the economics of scaling up. As a result, downstream processing presently accounts for a major portion of the processing costs of producing a biotechnological product.<br/>In order to cut down on costs and also to prevent the product loss that occurs during several purification stages, it is critical to  design processes that  possess high product recovery and resolution from impure feed streams.}},
  author       = {{Kaul, Rajni and Mattiasson, Bo}},
  booktitle    = {{Molecular Interactions in Bioseparations}},
  editor       = {{Ngo, That T.}},
  isbn         = {{0306444356}},
  language     = {{eng}},
  pages        = {{487--498}},
  publisher    = {{Plenum Press}},
  title        = {{Affinity ultrafiltration for protein purification}},
  url          = {{http://dx.doi.org/10.1007/978-1-4899-1872-7_32}},
  doi          = {{10.1007/978-1-4899-1872-7_32}},
  year         = {{1993}},
}