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Concentrates of buttermilk and krill oil improve cognition in aged rats

García-Serrano, Alba LU ; Tomé-Carneiro, Joao ; Carmen Crespo, M. ; Visitación Calvo, M. ; Pereda-Pérez, Inmaculada ; Baliyan, Shishir ; Burgos-Ramos, Emma ; Montero, Olimpio ; Dávalos, Alberto and Venero, César , et al. (2020) In Prostaglandins Leukotrienes and Essential Fatty Acids 155.
Abstract

Cognitive decline is one of the hallmarks of aging and can vary from mild cognitive impairment to dementia to Alzheimer's disease. In addition to some lifestyle interventions, there is room for the use of nutraceuticals/functional foods as pharma-nutritional tools to lessen the burden of cognitive decline before it worsens. We previously reported the promising molecular actions of milk fat globule membranes and krill oil concentrates in a rat model of aging. In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with... (More)

Cognitive decline is one of the hallmarks of aging and can vary from mild cognitive impairment to dementia to Alzheimer's disease. In addition to some lifestyle interventions, there is room for the use of nutraceuticals/functional foods as pharma-nutritional tools to lessen the burden of cognitive decline before it worsens. We previously reported the promising molecular actions of milk fat globule membranes and krill oil concentrates in a rat model of aging. In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with concentrates of polar lipids from buttermilk or krill oil at doses that approximate human consumption. No other behavioral parameter was significantly influenced by the supplements, calling for further research to confirm or not the purported salubrious activities of polar lipids, namely those rich in ω3 long-chain polyunsaturated fatty acids, on cognitive decline.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aging, Behavior, Cognitive decline, Functional foods, Milk, Nutraceuticals, Omega 3 fatty acids, Phospholipids
in
Prostaglandins Leukotrienes and Essential Fatty Acids
volume
155
article number
102077
publisher
Elsevier
external identifiers
  • pmid:32145667
  • scopus:85080114461
ISSN
0952-3278
DOI
10.1016/j.plefa.2020.102077
language
English
LU publication?
no
id
4c64e2f1-861e-4db7-a5de-d910cff9f5b8
date added to LUP
2020-03-18 12:44:15
date last changed
2020-10-27 02:32:57
@article{4c64e2f1-861e-4db7-a5de-d910cff9f5b8,
  abstract     = {<p>Cognitive decline is one of the hallmarks of aging and can vary from mild cognitive impairment to dementia to Alzheimer's disease. In addition to some lifestyle interventions, there is room for the use of nutraceuticals/functional foods as pharma-nutritional tools to lessen the burden of cognitive decline before it worsens. We previously reported the promising molecular actions of milk fat globule membranes and krill oil concentrates in a rat model of aging. In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with concentrates of polar lipids from buttermilk or krill oil at doses that approximate human consumption. No other behavioral parameter was significantly influenced by the supplements, calling for further research to confirm or not the purported salubrious activities of polar lipids, namely those rich in ω3 long-chain polyunsaturated fatty acids, on cognitive decline.</p>},
  author       = {García-Serrano, Alba and Tomé-Carneiro, Joao and Carmen Crespo, M. and Visitación Calvo, M. and Pereda-Pérez, Inmaculada and Baliyan, Shishir and Burgos-Ramos, Emma and Montero, Olimpio and Dávalos, Alberto and Venero, César and Visioli, Francesco and Fontecha, Javier},
  issn         = {0952-3278},
  language     = {eng},
  month        = {04},
  publisher    = {Elsevier},
  series       = {Prostaglandins Leukotrienes and Essential Fatty Acids},
  title        = {Concentrates of buttermilk and krill oil improve cognition in aged rats},
  url          = {http://dx.doi.org/10.1016/j.plefa.2020.102077},
  doi          = {10.1016/j.plefa.2020.102077},
  volume       = {155},
  year         = {2020},
}