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Insight into the Mammalian Aquaporin Interactome

Törnroth-Horsefield, Susanna LU ; Chivasso, Clara ; Strandberg, Helin LU ; D’Agostino, Claudia ; O’Neale, Carla V.T. ; Schey, Kevin L. and Delporte, Christine (2022) In International Journal of Molecular Sciences 23(17).
Abstract

Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO2, NH3, H2O2). Protein–protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addresses the molecular basis and functional significance of these protein–protein interactions in health and diseases. Targeting AQP interactomes may offer new therapeutic avenues as targeting individual AQPs remains challenging despite intense... (More)

Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO2, NH3, H2O2). Protein–protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addresses the molecular basis and functional significance of these protein–protein interactions in health and diseases. Targeting AQP interactomes may offer new therapeutic avenues as targeting individual AQPs remains challenging despite intense efforts.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aquaporin, function, interactome, mammalian, protein–protein interaction, trafficking
in
International Journal of Molecular Sciences
volume
23
issue
17
article number
9615
publisher
MDPI AG
external identifiers
  • pmid:36077012
  • scopus:85137850009
ISSN
1661-6596
DOI
10.3390/ijms23179615
language
English
LU publication?
yes
id
4c6a701a-5c25-4faa-b266-8f41efce06d8
date added to LUP
2022-12-02 09:10:45
date last changed
2025-03-21 18:27:13
@article{4c6a701a-5c25-4faa-b266-8f41efce06d8,
  abstract     = {{<p>Aquaporins (AQPs) are a family of transmembrane water channels expressed in all living organisms. AQPs facilitate osmotically driven water flux across biological membranes and, in some cases, the movement of small molecules (such as glycerol, urea, CO<sub>2</sub>, NH<sub>3</sub>, H<sub>2</sub>O<sub>2</sub>). Protein–protein interactions play essential roles in protein regulation and function. This review provides a comprehensive overview of the current knowledge of the AQP interactomes and addresses the molecular basis and functional significance of these protein–protein interactions in health and diseases. Targeting AQP interactomes may offer new therapeutic avenues as targeting individual AQPs remains challenging despite intense efforts.</p>}},
  author       = {{Törnroth-Horsefield, Susanna and Chivasso, Clara and Strandberg, Helin and D’Agostino, Claudia and O’Neale, Carla V.T. and Schey, Kevin L. and Delporte, Christine}},
  issn         = {{1661-6596}},
  keywords     = {{aquaporin; function; interactome; mammalian; protein–protein interaction; trafficking}},
  language     = {{eng}},
  number       = {{17}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{Insight into the Mammalian Aquaporin Interactome}},
  url          = {{http://dx.doi.org/10.3390/ijms23179615}},
  doi          = {{10.3390/ijms23179615}},
  volume       = {{23}},
  year         = {{2022}},
}