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Neurobiology of Postischemic Recuperation in the Aged Mammalian Brain

Popa-Wagner, Aurel ; Balseanu, Adrian ; Zagrean, Leon ; Shah, Imtiaz M. ; Di Napoli, Mario ; Ahlenius, Henrik LU and Kokaia, Zaal LU orcid (2010)
Abstract

Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are not well understood. Potential mechanism underlying functional recovery after brain ischemia in aged subjects include neuroinflammation, changes in brain plasticity-promoting factors, unregulated expression of neurotoxic factors, or differences in the generation of scar tissue that impedes the formation of new axons and blood vessels in the infarcted region. Studies suggest that behaviorally, aged rats were more severely impaired by ischemia than were young rats and showed diminished functional recovery. Both in old and young rats, the early intense proliferative activity... (More)

Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are not well understood. Potential mechanism underlying functional recovery after brain ischemia in aged subjects include neuroinflammation, changes in brain plasticity-promoting factors, unregulated expression of neurotoxic factors, or differences in the generation of scar tissue that impedes the formation of new axons and blood vessels in the infarcted region. Studies suggest that behaviorally, aged rats were more severely impaired by ischemia than were young rats and showed diminished functional recovery. Both in old and young rats, the early intense proliferative activity following stroke leads to a precipitous formation of growthinhibiting scar tissue, a phenomenon amplified by the persistent expression of neurotoxic factors. Recent evidence shows that the human brain can respond to stroke with increased progenitor proliferation in aged patients, opening the possibilities of utilizing this intrinsic attempt for neuroregeneration of the human brain as a potential therapy for ischemic stroke.

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author
; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Brain, Ischemic stroke, Neurobiology, Neuroinflammation, Neuroregeneration, Neurotoxic factors, Scar tissue
host publication
Neurovascular Medicine : Pursuing Cellular Longevity for Healthy Aging - Pursuing Cellular Longevity for Healthy Aging
publisher
Oxford University Press
external identifiers
  • scopus:84920579659
ISBN
9780195326697
9780199864874
DOI
10.1093/acprof:oso/9780195326697.003.0017
language
English
LU publication?
yes
id
4c75ec0f-8fab-4599-842e-6dec2a48bbee
date added to LUP
2019-09-03 16:57:30
date last changed
2025-02-04 02:53:53
@inbook{4c75ec0f-8fab-4599-842e-6dec2a48bbee,
  abstract     = {{<p>Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are not well understood. Potential mechanism underlying functional recovery after brain ischemia in aged subjects include neuroinflammation, changes in brain plasticity-promoting factors, unregulated expression of neurotoxic factors, or differences in the generation of scar tissue that impedes the formation of new axons and blood vessels in the infarcted region. Studies suggest that behaviorally, aged rats were more severely impaired by ischemia than were young rats and showed diminished functional recovery. Both in old and young rats, the early intense proliferative activity following stroke leads to a precipitous formation of growthinhibiting scar tissue, a phenomenon amplified by the persistent expression of neurotoxic factors. Recent evidence shows that the human brain can respond to stroke with increased progenitor proliferation in aged patients, opening the possibilities of utilizing this intrinsic attempt for neuroregeneration of the human brain as a potential therapy for ischemic stroke.</p>}},
  author       = {{Popa-Wagner, Aurel and Balseanu, Adrian and Zagrean, Leon and Shah, Imtiaz M. and Di Napoli, Mario and Ahlenius, Henrik and Kokaia, Zaal}},
  booktitle    = {{Neurovascular Medicine : Pursuing Cellular Longevity for Healthy Aging}},
  isbn         = {{9780195326697}},
  keywords     = {{Brain; Ischemic stroke; Neurobiology; Neuroinflammation; Neuroregeneration; Neurotoxic factors; Scar tissue}},
  language     = {{eng}},
  publisher    = {{Oxford University Press}},
  title        = {{Neurobiology of Postischemic Recuperation in the Aged Mammalian Brain}},
  url          = {{http://dx.doi.org/10.1093/acprof:oso/9780195326697.003.0017}},
  doi          = {{10.1093/acprof:oso/9780195326697.003.0017}},
  year         = {{2010}},
}