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Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors : A systematic review

Streefkerk, Nina ; Fioole, Lisanne C.E. ; Beijer, Josien G.M. ; Feijen, Elizabeth A.M. ; Teepen, Jop C. ; Winther, Jeanette F. ; Ronckers, Cecile M. ; Loonen, Jaqueline J. ; van Dulmen-den Broeder, Eline and Skinner, Rod , et al. (2020) In Pediatric Blood and Cancer 67(11).
Abstract

We systematically reviewed outcome assessment methods, outcome classification, and severity grading of reported outcomes in studies investigating the burden of physical long-term morbidity in childhood cancer survivors (CCS). A MEDLINE and EMBASE search identified 56 studies reporting on three or more types of health conditions in 5-year CCS, for which information was extracted on outcome types and classification, methods of outcome ascertainment, and severity grading. There was substantial variability in classification and types of health conditions reported and in methods of outcome ascertainment. Only 59% of the included studies applied severity grading, mainly the common terminology criteria of adverse events. This large variation... (More)

We systematically reviewed outcome assessment methods, outcome classification, and severity grading of reported outcomes in studies investigating the burden of physical long-term morbidity in childhood cancer survivors (CCS). A MEDLINE and EMBASE search identified 56 studies reporting on three or more types of health conditions in 5-year CCS, for which information was extracted on outcome types and classification, methods of outcome ascertainment, and severity grading. There was substantial variability in classification and types of health conditions reported and in methods of outcome ascertainment. Only 59% of the included studies applied severity grading, mainly the common terminology criteria of adverse events. This large variation in assessment and definition of the burden of physical long-term morbidity in CCS challenges interpretation, comparison, and pooling data across studies. Global collaboration is needed to standardize assessments and harmonize definitions of long-term physical morbidity and associated outcomes in childhood cancer survivorship research.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
childhood cancer survivors, long-term morbidity, outcome assessment, outcome definition, severity grading
in
Pediatric Blood and Cancer
volume
67
issue
11
article number
e28611
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:32881287
  • scopus:85090161887
ISSN
1545-5009
DOI
10.1002/pbc.28611
language
English
LU publication?
no
id
4c938b3b-7471-422c-8000-284b47cc34f6
date added to LUP
2021-01-15 08:07:20
date last changed
2024-01-17 21:14:14
@article{4c938b3b-7471-422c-8000-284b47cc34f6,
  abstract     = {{<p>We systematically reviewed outcome assessment methods, outcome classification, and severity grading of reported outcomes in studies investigating the burden of physical long-term morbidity in childhood cancer survivors (CCS). A MEDLINE and EMBASE search identified 56 studies reporting on three or more types of health conditions in 5-year CCS, for which information was extracted on outcome types and classification, methods of outcome ascertainment, and severity grading. There was substantial variability in classification and types of health conditions reported and in methods of outcome ascertainment. Only 59% of the included studies applied severity grading, mainly the common terminology criteria of adverse events. This large variation in assessment and definition of the burden of physical long-term morbidity in CCS challenges interpretation, comparison, and pooling data across studies. Global collaboration is needed to standardize assessments and harmonize definitions of long-term physical morbidity and associated outcomes in childhood cancer survivorship research.</p>}},
  author       = {{Streefkerk, Nina and Fioole, Lisanne C.E. and Beijer, Josien G.M. and Feijen, Elizabeth A.M. and Teepen, Jop C. and Winther, Jeanette F. and Ronckers, Cecile M. and Loonen, Jaqueline J. and van Dulmen-den Broeder, Eline and Skinner, Rod and Hudson, Melissa M. and Tissing, Wim J.E. and Korevaar, Joke C. and Mulder, Renée L. and Kremer, Leontine C.M.}},
  issn         = {{1545-5009}},
  keywords     = {{childhood cancer survivors; long-term morbidity; outcome assessment; outcome definition; severity grading}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Pediatric Blood and Cancer}},
  title        = {{Large variation in assessment and outcome definitions to describe the burden of long-term morbidity in childhood cancer survivors : A systematic review}},
  url          = {{http://dx.doi.org/10.1002/pbc.28611}},
  doi          = {{10.1002/pbc.28611}},
  volume       = {{67}},
  year         = {{2020}},
}