Advanced

High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage

Gazzolo, D ; Marinoni, E ; Di Iorio, R ; Lituania, M ; Marras, M ; Bruschettini, Matteo LU ; Bruschettini, P ; Frulio, R ; Michetti, F and Petraglia, F , et al. (2006) In Clinical Chemistry 52(5). p.819-826
Abstract
Background: Intrauterine growth restriction (IUGR) is associated with perinatal mortality and with neurologic damage from intraventricular hemorrhage (IVH). We investigated whether S100B, a neural protein found in high concentrations after cell injury in the nervous system, is increased in serum of women whose pregnancies are complicated by IUGR and whose newborns develop IVH. We also explored the prognostic accuracy of maternal serum S100B for IVH in the newborn. Methods: We conducted a case-control study of 106 pregnancies complicated by IUGR, including a subgroup (n = 26) who developed IVH after birth, and 212 unaffected pregnancies matched for gestational age. Ultrasound examination, Doppler velocimetry patterns (in the utero-placental... (More)
Background: Intrauterine growth restriction (IUGR) is associated with perinatal mortality and with neurologic damage from intraventricular hemorrhage (IVH). We investigated whether S100B, a neural protein found in high concentrations after cell injury in the nervous system, is increased in serum of women whose pregnancies are complicated by IUGR and whose newborns develop IVH. We also explored the prognostic accuracy of maternal serum S100B for IVH in the newborn. Methods: We conducted a case-control study of 106 pregnancies complicated by IUGR, including a subgroup (n = 26) who developed IVH after birth, and 212 unaffected pregnancies matched for gestational age. Ultrasound examination, Doppler velocimetry patterns (in the utero-placental vessels and middle cerebral artery), and maternal blood collection were performed before birth; cerebral ultrasound and neurologic examinations were performed after birth. Results: S100B was higher (P < 0.001) in IUGR pregnancies complicated by IVH than in those that were not and in controls. At a cutoff of 0.72 mu g/L, sensitivity was 100% [95% confidence interval (95% CI), 87%-100%] and specificity was 99.3% (97.5%-99.9%) for prediction of IVH (area under the ROC curve, 0.999). The prevalence of IVH was 8.2% in the whole study population, 93% (95% CI, 83.6%-100%) in those with maternal S100B > 0.72 mu g/L, and 0% (0%-2.5%) in those with maternal S100B < 0.72 mu g/L. Conclusion: For prediction of IVH, measurements of maternal S100B may be useful at times before clinical, laboratory, and ultrasound patterns can identify risk of IVH. (c) 2006 American Association for Clinical Chemistry. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Chemistry
volume
52
issue
5
pages
819 - 826
publisher
American Association for Clinical Chemistry
external identifiers
  • wos:000237339600006
  • scopus:33646370239
ISSN
0009-9147
DOI
10.1373/clinchem.2005.060665
language
English
LU publication?
no
id
4c99cd3c-ffac-41a0-9c0d-4e17744a722b (old id 7856209)
date added to LUP
2016-04-01 11:41:08
date last changed
2020-01-07 04:17:41
@article{4c99cd3c-ffac-41a0-9c0d-4e17744a722b,
  abstract     = {Background: Intrauterine growth restriction (IUGR) is associated with perinatal mortality and with neurologic damage from intraventricular hemorrhage (IVH). We investigated whether S100B, a neural protein found in high concentrations after cell injury in the nervous system, is increased in serum of women whose pregnancies are complicated by IUGR and whose newborns develop IVH. We also explored the prognostic accuracy of maternal serum S100B for IVH in the newborn. Methods: We conducted a case-control study of 106 pregnancies complicated by IUGR, including a subgroup (n = 26) who developed IVH after birth, and 212 unaffected pregnancies matched for gestational age. Ultrasound examination, Doppler velocimetry patterns (in the utero-placental vessels and middle cerebral artery), and maternal blood collection were performed before birth; cerebral ultrasound and neurologic examinations were performed after birth. Results: S100B was higher (P &lt; 0.001) in IUGR pregnancies complicated by IVH than in those that were not and in controls. At a cutoff of 0.72 mu g/L, sensitivity was 100% [95% confidence interval (95% CI), 87%-100%] and specificity was 99.3% (97.5%-99.9%) for prediction of IVH (area under the ROC curve, 0.999). The prevalence of IVH was 8.2% in the whole study population, 93% (95% CI, 83.6%-100%) in those with maternal S100B &gt; 0.72 mu g/L, and 0% (0%-2.5%) in those with maternal S100B &lt; 0.72 mu g/L. Conclusion: For prediction of IVH, measurements of maternal S100B may be useful at times before clinical, laboratory, and ultrasound patterns can identify risk of IVH. (c) 2006 American Association for Clinical Chemistry.},
  author       = {Gazzolo, D and Marinoni, E and Di Iorio, R and Lituania, M and Marras, M and Bruschettini, Matteo and Bruschettini, P and Frulio, R and Michetti, F and Petraglia, F and Florio, P},
  issn         = {0009-9147},
  language     = {eng},
  number       = {5},
  pages        = {819--826},
  publisher    = {American Association for Clinical Chemistry},
  series       = {Clinical Chemistry},
  title        = {High maternal blood S100B concentrations in pregnancies complicated by intrauterine growth restriction and intraventricular hemorrhage},
  url          = {http://dx.doi.org/10.1373/clinchem.2005.060665},
  doi          = {10.1373/clinchem.2005.060665},
  volume       = {52},
  year         = {2006},
}