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Exposing the exposures responsible for type 2 diabetes and obesity

Franks, Paul W. LU and McCarthy, Mark I. (2016) In Science 354(6308). p.69-73
Abstract

The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although "Western" lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can... (More)

The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although "Western" lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Science
volume
354
issue
6308
pages
5 pages
publisher
The American Association for the Advancement of Science
external identifiers
  • scopus:84990957256
  • wos:000387777900030
ISSN
0036-8075
DOI
10.1126/science.aaf5094
language
English
LU publication?
yes
id
4cdabc4f-4f41-419a-a5a2-51232d583da4
date added to LUP
2016-11-01 08:44:07
date last changed
2017-11-19 04:34:25
@article{4cdabc4f-4f41-419a-a5a2-51232d583da4,
  abstract     = {<p>The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although "Western" lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions.</p>},
  author       = {Franks, Paul W. and McCarthy, Mark I.},
  issn         = {0036-8075},
  language     = {eng},
  month        = {10},
  number       = {6308},
  pages        = {69--73},
  publisher    = {The American Association for the Advancement of Science},
  series       = {Science},
  title        = {Exposing the exposures responsible for type 2 diabetes and obesity},
  url          = {http://dx.doi.org/10.1126/science.aaf5094},
  volume       = {354},
  year         = {2016},
}