Exposing the exposures responsible for type 2 diabetes and obesity
(2016) In Science 354(6308). p.69-73- Abstract
The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although "Western" lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can... (More)
The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although "Western" lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions.
(Less)
- author
- Franks, Paul W. LU and McCarthy, Mark I.
- organization
- publishing date
- 2016-10-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 354
- issue
- 6308
- pages
- 5 pages
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- scopus:84990957256
- pmid:27846494
- wos:000387777900030
- ISSN
- 0036-8075
- DOI
- 10.1126/science.aaf5094
- language
- English
- LU publication?
- yes
- id
- 4cdabc4f-4f41-419a-a5a2-51232d583da4
- date added to LUP
- 2016-11-01 08:44:07
- date last changed
- 2025-01-11 14:20:25
@article{4cdabc4f-4f41-419a-a5a2-51232d583da4,
abstract = {{<p>The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although "Western" lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions.</p>}},
author = {{Franks, Paul W. and McCarthy, Mark I.}},
issn = {{0036-8075}},
language = {{eng}},
month = {{10}},
number = {{6308}},
pages = {{69--73}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science}},
title = {{Exposing the exposures responsible for type 2 diabetes and obesity}},
url = {{http://dx.doi.org/10.1126/science.aaf5094}},
doi = {{10.1126/science.aaf5094}},
volume = {{354}},
year = {{2016}},
}