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Unraveling the brain's response to COVID-19 : How SARS-CoV-2 afflicts dopaminergic neurons

Eidhof, Ilse ; Twohig, Daniel LU orcid and Falk, Anna LU (2024) In Cell Stem Cell 31(2). p.152-154
Abstract

COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Stem Cell
volume
31
issue
2
pages
3 pages
publisher
Cell Press
external identifiers
  • pmid:38306990
  • scopus:85183508324
ISSN
1934-5909
DOI
10.1016/j.stem.2024.01.002
language
English
LU publication?
yes
id
4cdf59d9-bdd6-4891-9461-98dcf304184f
date added to LUP
2024-02-19 15:03:02
date last changed
2024-04-19 17:06:23
@misc{4cdf59d9-bdd6-4891-9461-98dcf304184f,
  abstract     = {{<p>COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.</p>}},
  author       = {{Eidhof, Ilse and Twohig, Daniel and Falk, Anna}},
  issn         = {{1934-5909}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{2}},
  pages        = {{152--154}},
  publisher    = {{Cell Press}},
  series       = {{Cell Stem Cell}},
  title        = {{Unraveling the brain's response to COVID-19 : How SARS-CoV-2 afflicts dopaminergic neurons}},
  url          = {{http://dx.doi.org/10.1016/j.stem.2024.01.002}},
  doi          = {{10.1016/j.stem.2024.01.002}},
  volume       = {{31}},
  year         = {{2024}},
}