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High Prevalence of Gestational Diabetes Mellitus in Rural Tanzania-Diagnosis Mainly Based on Fasting Blood Glucose from Oral Glucose Tolerance Test

Grunnet, Louise Groth ; Hjort, Line LU ; Minja, Daniel Thomas ; Msemo, Omari Abdul ; Møller, Sofie Lykke ; Prasad, Rashmi B LU ; Groop, Leif LU ; Lusingu, John ; Nielsen, Birgitte Bruun and Schmiegelow, Christentze , et al. (2020) In International Journal of Environmental Research and Public Health 17(9).
Abstract

Gestational diabetes mellitus (GDM) is associated with poor pregnancy outcomes and increased long-term risk of metabolic diseases for both mother and child. In Tanzania, GDM prevalence increased from 0% in 1991 to 19.5% in 2016. Anaemia has been proposed to precipitate the pathogenesis of GDM. We aimed to examine the prevalence of GDM in a rural area of Tanzania with a high prevalence of anaemia and to examine a potential association between haemoglobin concentration and blood glucose during pregnancy. The participants were included in a population-based preconception, pregnancy and birth cohort study. In total, 538 women were followed during pregnancy and scheduled for an oral glucose tolerance test (OGTT) at week 32-34 of gestation.... (More)

Gestational diabetes mellitus (GDM) is associated with poor pregnancy outcomes and increased long-term risk of metabolic diseases for both mother and child. In Tanzania, GDM prevalence increased from 0% in 1991 to 19.5% in 2016. Anaemia has been proposed to precipitate the pathogenesis of GDM. We aimed to examine the prevalence of GDM in a rural area of Tanzania with a high prevalence of anaemia and to examine a potential association between haemoglobin concentration and blood glucose during pregnancy. The participants were included in a population-based preconception, pregnancy and birth cohort study. In total, 538 women were followed during pregnancy and scheduled for an oral glucose tolerance test (OGTT) at week 32-34 of gestation. Gestational diabetes mellitus was diagnosed according to the WHO 2013 guidelines. Out of 392 women screened, 39% (95% CI: 34.2-44.1) had GDM, the majority of whom (94.1%) were diagnosed based solely on the fasting blood sample from the OGTT. No associations were observed between haemoglobin or ferritin and glucose measurements during pregnancy. A very high prevalence of GDM was found in rural Tanzania. In view of the laborious, costly and inconvenient OGTT, alternative methods such as fasting blood glucose should be considered when screening for GDM in low- and middle-income countries.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Environmental Research and Public Health
volume
17
issue
9
article number
3109
publisher
MDPI AG
external identifiers
  • scopus:85084276483
  • pmid:32365670
ISSN
1660-4601
DOI
10.3390/ijerph17093109
language
English
LU publication?
yes
id
4cf3eb7f-4901-470b-bef4-748f4e5aa773
date added to LUP
2020-05-29 12:15:57
date last changed
2024-06-12 14:31:54
@article{4cf3eb7f-4901-470b-bef4-748f4e5aa773,
  abstract     = {{<p>Gestational diabetes mellitus (GDM) is associated with poor pregnancy outcomes and increased long-term risk of metabolic diseases for both mother and child. In Tanzania, GDM prevalence increased from 0% in 1991 to 19.5% in 2016. Anaemia has been proposed to precipitate the pathogenesis of GDM. We aimed to examine the prevalence of GDM in a rural area of Tanzania with a high prevalence of anaemia and to examine a potential association between haemoglobin concentration and blood glucose during pregnancy. The participants were included in a population-based preconception, pregnancy and birth cohort study. In total, 538 women were followed during pregnancy and scheduled for an oral glucose tolerance test (OGTT) at week 32-34 of gestation. Gestational diabetes mellitus was diagnosed according to the WHO 2013 guidelines. Out of 392 women screened, 39% (95% CI: 34.2-44.1) had GDM, the majority of whom (94.1%) were diagnosed based solely on the fasting blood sample from the OGTT. No associations were observed between haemoglobin or ferritin and glucose measurements during pregnancy. A very high prevalence of GDM was found in rural Tanzania. In view of the laborious, costly and inconvenient OGTT, alternative methods such as fasting blood glucose should be considered when screening for GDM in low- and middle-income countries.</p>}},
  author       = {{Grunnet, Louise Groth and Hjort, Line and Minja, Daniel Thomas and Msemo, Omari Abdul and Møller, Sofie Lykke and Prasad, Rashmi B and Groop, Leif and Lusingu, John and Nielsen, Birgitte Bruun and Schmiegelow, Christentze and Bygbjerg, Ib Christian and Christensen, Dirk Lund}},
  issn         = {{1660-4601}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{9}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Environmental Research and Public Health}},
  title        = {{High Prevalence of Gestational Diabetes Mellitus in Rural Tanzania-Diagnosis Mainly Based on Fasting Blood Glucose from Oral Glucose Tolerance Test}},
  url          = {{http://dx.doi.org/10.3390/ijerph17093109}},
  doi          = {{10.3390/ijerph17093109}},
  volume       = {{17}},
  year         = {{2020}},
}