Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes
(2022) In Acta Ophthalmologica 100(2).- Abstract
PURPOSE: Intrauterine undernutrition is associated with increased risk of type 2 diabetes. Children born premature or small for gestational age were reported to have abnormal retinal vascularization. However, whether intrauterine famine act as a trigger for diabetes complications, including retinopathy, is unknown. The aim of the current study was to evaluate long-term effects of perinatal famine on the risk of proliferative diabetic retinopathy (PDR).
METHODS: We studied the risk for PDR among type 2 diabetes patients exposed to perinatal famine in two independent cohorts: the Ukrainian National Diabetes Registry (UNDR) and the Hong Kong Diabetes Registry (HKDR). We analysed individuals born during the Great Famine (the... (More)
PURPOSE: Intrauterine undernutrition is associated with increased risk of type 2 diabetes. Children born premature or small for gestational age were reported to have abnormal retinal vascularization. However, whether intrauterine famine act as a trigger for diabetes complications, including retinopathy, is unknown. The aim of the current study was to evaluate long-term effects of perinatal famine on the risk of proliferative diabetic retinopathy (PDR).
METHODS: We studied the risk for PDR among type 2 diabetes patients exposed to perinatal famine in two independent cohorts: the Ukrainian National Diabetes Registry (UNDR) and the Hong Kong Diabetes Registry (HKDR). We analysed individuals born during the Great Famine (the Holodomor, 1932-1933) and the WWII (1941-1945) famine in 101 095 (3601 had PDR) UNDR participants. Among 3021 (251 had PDR) HKDR participants, we studied type 2 diabetes patients exposed to perinatal famine during the WWII Japanese invasion in 1942-1945.
RESULTS: During the Holodomor and WWII, perinatal famine was associated with a 1.76-fold (p = 0.019) and 3.02-fold (p = 0.001) increased risk of severe PDR in the UNDR. The risk for PDR was 1.66-fold elevated among individuals born in 1942 in the HKDR (p < 0.05). The associations between perinatal famine and PDR remained statistically significant after corrections for HbA1c in available 18 507 UNDR (padditive interaction < 0.001) and in 3021 HKDR type 2 diabetes patients (p < 0.05).
CONCLUSION: In conclusion, type 2 diabetes patients, exposed to perinatal famine, have increased risk of PDR compared to those without perinatal famine exposure. Further studies are needed to understand the underlying mechanisms and to extend this finding to other diabetes complications.
(Less)
- author
- organization
-
- Islet cell physiology (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Translational Muscle Research (research group)
- Antigen Presentation (research group)
- Medical Protein Science (research group)
- Endocrine Cell Differentiation and Function (research group)
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- Stem Cell Center
- History of Medicine
- Internal Medicine - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Ophthalmologica
- volume
- 100
- issue
- 2
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:34169655
- scopus:85108415228
- ISSN
- 1755-3768
- DOI
- 10.1111/aos.14948
- language
- English
- LU publication?
- yes
- additional info
- © 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
- id
- 4d014f32-b639-4f4f-9eae-f704ca470332
- date added to LUP
- 2021-10-13 15:54:43
- date last changed
- 2024-04-20 13:38:46
@article{4d014f32-b639-4f4f-9eae-f704ca470332,
abstract = {{<p>PURPOSE: Intrauterine undernutrition is associated with increased risk of type 2 diabetes. Children born premature or small for gestational age were reported to have abnormal retinal vascularization. However, whether intrauterine famine act as a trigger for diabetes complications, including retinopathy, is unknown. The aim of the current study was to evaluate long-term effects of perinatal famine on the risk of proliferative diabetic retinopathy (PDR).</p><p>METHODS: We studied the risk for PDR among type 2 diabetes patients exposed to perinatal famine in two independent cohorts: the Ukrainian National Diabetes Registry (UNDR) and the Hong Kong Diabetes Registry (HKDR). We analysed individuals born during the Great Famine (the Holodomor, 1932-1933) and the WWII (1941-1945) famine in 101 095 (3601 had PDR) UNDR participants. Among 3021 (251 had PDR) HKDR participants, we studied type 2 diabetes patients exposed to perinatal famine during the WWII Japanese invasion in 1942-1945.</p><p>RESULTS: During the Holodomor and WWII, perinatal famine was associated with a 1.76-fold (p = 0.019) and 3.02-fold (p = 0.001) increased risk of severe PDR in the UNDR. The risk for PDR was 1.66-fold elevated among individuals born in 1942 in the HKDR (p < 0.05). The associations between perinatal famine and PDR remained statistically significant after corrections for HbA1c in available 18 507 UNDR (padditive interaction < 0.001) and in 3021 HKDR type 2 diabetes patients (p < 0.05).</p><p>CONCLUSION: In conclusion, type 2 diabetes patients, exposed to perinatal famine, have increased risk of PDR compared to those without perinatal famine exposure. Further studies are needed to understand the underlying mechanisms and to extend this finding to other diabetes complications.</p>}},
author = {{Fedotkina, Olena and Luk, Andrea and Jain, Ruchi and Prasad, Rashmi B and Shungin, Dmitry and Simó-Servat, Olga and Özgümüs, Türküler and Cherviakova, Liubov and Khalimon, Nadiya and Svietleisha, Tetiana and Buldenko, Tetiana and Kravchenko, Victor and Hernández, Cristina and Jain, Deepak and Simo, Rafael and Artner, Isabella and Nilsson, Peter M and Khalangot, Mykola D and Vaiserman, Alexander M and Chan, Juliana and Vaag, Allan and Lyssenko, Valeriya}},
issn = {{1755-3768}},
language = {{eng}},
number = {{2}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Ophthalmologica}},
title = {{Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes}},
url = {{http://dx.doi.org/10.1111/aos.14948}},
doi = {{10.1111/aos.14948}},
volume = {{100}},
year = {{2022}},
}