Surgery for advanced neuroendocrine tumours of the small bowel : Recommendations based on a consensus meeting of the European Society of Endocrine Surgeons (ESES)
(2024) In British Journal of Surgery 111(4).- Abstract
Background: Small bowel neuroendocrine tumours often present with locally advanced or metastatic disease. The aim of this paper is to provide evidence-based recommendations regarding (controversial) topics in the surgical management of advanced small bowel neuroendocrine tumours. Methods: A working group of experts was formed by the European Society of Endocrine Surgeons. The group addressed 11 clinically relevant questions regarding surgery for advanced disease, including the benefit of primary tumour resection, the role of cytoreduction, the extent of lymph node clearance, and the management of an unknown primary tumour. A systematic literature search was performed in MEDLINE to identify papers addressing the research questions. Final... (More)
Background: Small bowel neuroendocrine tumours often present with locally advanced or metastatic disease. The aim of this paper is to provide evidence-based recommendations regarding (controversial) topics in the surgical management of advanced small bowel neuroendocrine tumours. Methods: A working group of experts was formed by the European Society of Endocrine Surgeons. The group addressed 11 clinically relevant questions regarding surgery for advanced disease, including the benefit of primary tumour resection, the role of cytoreduction, the extent of lymph node clearance, and the management of an unknown primary tumour. A systematic literature search was performed in MEDLINE to identify papers addressing the research questions. Final recommendations were presented and voted upon by European Society of Endocrine Surgeons members at the European Society of Endocrine Surgeons Conference in Mainz in 2023. Results: The literature review yielded 1223 papers, of which 84 were included. There were no randomized controlled trials to address any of the research questions and therefore conclusions were based on the available case series, cohort studies, and systematic reviews/meta-analyses of the available non-randomized studies. The proposed recommendations were scored by 38-51 members and rated 'strongly agree' or 'agree' by 64-96% of participants. Conclusion: This paper provides recommendations based on the best available evidence and expert opinion on the surgical management of locally advanced and metastatic small bowel neuroendocrine tumours.
(Less)
- author
- Van Den Heede, Klaas ; Van Beek, Dirk Jan ; Van Slycke, Sam ; Borel Rinkes, Inne ; Norlén, Olov ; Stålberg, Peter and Nordenström, Erik LU
- organization
- publishing date
- 2024-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Surgery
- volume
- 111
- issue
- 4
- article number
- znae082
- publisher
- Oxford University Press
- external identifiers
-
- pmid:38626261
- scopus:85190904284
- ISSN
- 0007-1323
- DOI
- 10.1093/bjs/znae082
- language
- English
- LU publication?
- yes
- id
- 4d96e6fb-4706-47ec-9bac-8cbefcac5041
- date added to LUP
- 2025-01-14 13:54:26
- date last changed
- 2025-07-02 17:11:10
@article{4d96e6fb-4706-47ec-9bac-8cbefcac5041,
abstract = {{<p>Background: Small bowel neuroendocrine tumours often present with locally advanced or metastatic disease. The aim of this paper is to provide evidence-based recommendations regarding (controversial) topics in the surgical management of advanced small bowel neuroendocrine tumours. Methods: A working group of experts was formed by the European Society of Endocrine Surgeons. The group addressed 11 clinically relevant questions regarding surgery for advanced disease, including the benefit of primary tumour resection, the role of cytoreduction, the extent of lymph node clearance, and the management of an unknown primary tumour. A systematic literature search was performed in MEDLINE to identify papers addressing the research questions. Final recommendations were presented and voted upon by European Society of Endocrine Surgeons members at the European Society of Endocrine Surgeons Conference in Mainz in 2023. Results: The literature review yielded 1223 papers, of which 84 were included. There were no randomized controlled trials to address any of the research questions and therefore conclusions were based on the available case series, cohort studies, and systematic reviews/meta-analyses of the available non-randomized studies. The proposed recommendations were scored by 38-51 members and rated 'strongly agree' or 'agree' by 64-96% of participants. Conclusion: This paper provides recommendations based on the best available evidence and expert opinion on the surgical management of locally advanced and metastatic small bowel neuroendocrine tumours.</p>}},
author = {{Van Den Heede, Klaas and Van Beek, Dirk Jan and Van Slycke, Sam and Borel Rinkes, Inne and Norlén, Olov and Stålberg, Peter and Nordenström, Erik}},
issn = {{0007-1323}},
language = {{eng}},
month = {{04}},
number = {{4}},
publisher = {{Oxford University Press}},
series = {{British Journal of Surgery}},
title = {{Surgery for advanced neuroendocrine tumours of the small bowel : Recommendations based on a consensus meeting of the European Society of Endocrine Surgeons (ESES)}},
url = {{http://dx.doi.org/10.1093/bjs/znae082}},
doi = {{10.1093/bjs/znae082}},
volume = {{111}},
year = {{2024}},
}