Hyponatremia, hypernatremia and impairment of functional, psychological and sexual domains
(2023) In Journal of Endocrinological Investigation- Abstract
Objective: To determine the influence of serum sodium on physical, psychologic and sexual function. Methods: This is a cross-sectional survey on 3340 community-dwelling men aged 40–79 years from a prospective cohort study in eight European countries, the European Male Ageing Study (EMAS). Participants filled-out the Short Form-36 (SF-36), the Physical Activity Scale for the Elderly (PASE), and the EMAS sexual function questionnaire. For all the analyses, serum sodium corrected for glycaemia ([Na+]G) was used. Results: The relationship between [Na+]G and SF-36 physical function score (F = 3.99; p = 0.01), SF-36 mental health score (F = 7.69; p < 0.001), and PASE score (F = 14.95; p <... (More)
Objective: To determine the influence of serum sodium on physical, psychologic and sexual function. Methods: This is a cross-sectional survey on 3340 community-dwelling men aged 40–79 years from a prospective cohort study in eight European countries, the European Male Ageing Study (EMAS). Participants filled-out the Short Form-36 (SF-36), the Physical Activity Scale for the Elderly (PASE), and the EMAS sexual function questionnaire. For all the analyses, serum sodium corrected for glycaemia ([Na+]G) was used. Results: The relationship between [Na+]G and SF-36 physical function score (F = 3.99; p = 0.01), SF-36 mental health score (F = 7.69; p < 0.001), and PASE score (F = 14.95; p < 0.001) were best described by a quadratic equation, with worse scores for [Na+]G in either the lowest or the highest ends of the range. After dividing the sample into [Na+]G < 136 mmol/L (n = 81), 136–147 mmol/L (n = 3223) and > 147 mmol/L (n = 36), linear regression analyses with linear spline functions adjusted for confounders did not confirm these relationships. Similarly, erectile dysfunction and [Na+]G, were in a quadratic relationship (F = 9.00; p < 0.001). After adjusting for confounders, the linear regression with spline functions denoted a significantly worsened erectile function for increases in serum [Na+]G > 147 mmol/L (B = 0.15 [0.04;0.26], p < 0.01) but no relationship with [Na+]G < 136 mmol/L. Likewise, the relationship of [Na+]G with concerns about sexual dysfunction was confirmed only for men with serum [Na+]G > 147 mmol/L. Conclusions: This is the first study supporting an association between [Na+]G and sexual function. A worsening of erection and concerns about sexual function were observed for the highest values of [Na+]G, independently of other relevant factors.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- in press
- subject
- keywords
- Erectile dysfunction, Hypernatremia, Hyponatremia, Physical function, Psychologic function, Sexual function
- in
- Journal of Endocrinological Investigation
- publisher
- Springer
- external identifiers
-
- pmid:37884780
- scopus:85174806534
- ISSN
- 0391-4097
- DOI
- 10.1007/s40618-023-02218-w
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2023, The Author(s).
- id
- 4ddad769-0989-485d-97f6-f87c334292eb
- date added to LUP
- 2023-12-18 11:09:36
- date last changed
- 2024-04-16 23:18:28
@article{4ddad769-0989-485d-97f6-f87c334292eb,
abstract = {{<p>Objective: To determine the influence of serum sodium on physical, psychologic and sexual function. Methods: This is a cross-sectional survey on 3340 community-dwelling men aged 40–79 years from a prospective cohort study in eight European countries, the European Male Ageing Study (EMAS). Participants filled-out the Short Form-36 (SF-36), the Physical Activity Scale for the Elderly (PASE), and the EMAS sexual function questionnaire. For all the analyses, serum sodium corrected for glycaemia ([Na<sup>+</sup>]<sub>G</sub>) was used. Results: The relationship between [Na<sup>+</sup>]<sub>G</sub> and SF-36 physical function score (F = 3.99; p = 0.01), SF-36 mental health score (F = 7.69; p < 0.001), and PASE score (F = 14.95; p < 0.001) were best described by a quadratic equation, with worse scores for [Na<sup>+</sup>]<sub>G</sub> in either the lowest or the highest ends of the range. After dividing the sample into [Na<sup>+</sup>]<sub>G</sub> < 136 mmol/L (n = 81), 136–147 mmol/L (n = 3223) and > 147 mmol/L (n = 36), linear regression analyses with linear spline functions adjusted for confounders did not confirm these relationships. Similarly, erectile dysfunction and [Na<sup>+</sup>]<sub>G</sub>, were in a quadratic relationship (F = 9.00; p < 0.001). After adjusting for confounders, the linear regression with spline functions denoted a significantly worsened erectile function for increases in serum [Na<sup>+</sup>]<sub>G</sub> > 147 mmol/L (B = 0.15 [0.04;0.26], p < 0.01) but no relationship with [Na<sup>+</sup>]<sub>G</sub> < 136 mmol/L. Likewise, the relationship of [Na<sup>+</sup>]<sub>G</sub> with concerns about sexual dysfunction was confirmed only for men with serum [Na<sup>+</sup>]<sub>G</sub> > 147 mmol/L. Conclusions: This is the first study supporting an association between [Na<sup>+</sup>]<sub>G</sub> and sexual function. A worsening of erection and concerns about sexual function were observed for the highest values of [Na<sup>+</sup>]<sub>G</sub>, independently of other relevant factors.</p>}},
author = {{Norello, D. and Rastrelli, G. and Antonio, L. and Bartfai, G. and Casanueva, F. F. and Giwercman, A. and Huhtaniemi, I. T. and O’Neill, T. W. and Punab, M. and Slowikowska-Hilczer, J. and Tournoy, J. and Vanderschueren, D. and Wu, F. C.W. and Maggi, M. and Peri, A.}},
issn = {{0391-4097}},
keywords = {{Erectile dysfunction; Hypernatremia; Hyponatremia; Physical function; Psychologic function; Sexual function}},
language = {{eng}},
publisher = {{Springer}},
series = {{Journal of Endocrinological Investigation}},
title = {{Hyponatremia, hypernatremia and impairment of functional, psychological and sexual domains}},
url = {{http://dx.doi.org/10.1007/s40618-023-02218-w}},
doi = {{10.1007/s40618-023-02218-w}},
year = {{2023}},
}