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Umbilical artery Doppler in relation to placental pathology and FV Leiden in pregnant women and their offspring

Lindqvist, P. G. ; Prochazka, M. ; Laurini, Ricardo LU and Marsal, Karel LU (2013) In Journal of Maternal-Fetal & Neonatal Medicine 26(14). p.1394-1398
Abstract
Objective: Abnormal umbilical artery blood flow has been implicated in pregnancy complications and fetal demise. Its relation to histopathological changes in the placenta and to maternal or fetal thrombophilia is less well understood. The aim of this study was to evaluate the relation between umbilical artery Doppler findings, placental histopathology, and maternal and fetal coagulation factor V Leiden (FVL) status. Methods: Two previous studies on FVL in pregnancy made the placentas of 25 women with maternal FVL carriership and 43 randomly selected non-carriers available for a histopathological examination. Umbilical artery Doppler velocimetry was performed on 54 women in late pregnancy. Results: Abnormal umbilical artery Doppler... (More)
Objective: Abnormal umbilical artery blood flow has been implicated in pregnancy complications and fetal demise. Its relation to histopathological changes in the placenta and to maternal or fetal thrombophilia is less well understood. The aim of this study was to evaluate the relation between umbilical artery Doppler findings, placental histopathology, and maternal and fetal coagulation factor V Leiden (FVL) status. Methods: Two previous studies on FVL in pregnancy made the placentas of 25 women with maternal FVL carriership and 43 randomly selected non-carriers available for a histopathological examination. Umbilical artery Doppler velocimetry was performed on 54 women in late pregnancy. Results: Abnormal umbilical artery Doppler velocimetry was associated with an approximately sevenfold increased risk of fetoplacental thrombotic vasculopathy (odds ratio [OR]: 7.5, 95% confidence intervals [CI]: 1.3-44.3), ischemic lesions (OR: 7.5, 95% CI: 1.2-46.1) and fetal carriership of FVL (OR: 8.2, 95% CI: 1.5-43.5), but not maternal FVL. Fetal FVL carriership was also associated with a sevenfold increased risk of ischemic lesions (OR: 6.7, 95% CI: 1.3-35). Conclusions: Our results indicate that the fetal - not the maternal - FVL carriership matters regarding the umbilical artery blood flow and placental pathology, which might explain some of the heterogeneity of studies. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Doppler, factor V Leiden, fetal carriership, fetoplacental vasculopathy, ischemic lesions, obsteric complications, perinatal outcome, placenta, pulsatility index, thrombophilia
in
Journal of Maternal-Fetal & Neonatal Medicine
volume
26
issue
14
pages
1394 - 1398
publisher
Taylor & Francis
external identifiers
  • wos:000323333300005
  • scopus:84882432261
  • pmid:23544862
ISSN
1476-7058
DOI
10.3109/14767058.2013.791269
language
English
LU publication?
yes
id
4de83db7-20fe-4217-b4b7-94af779390b3 (old id 4062366)
date added to LUP
2016-04-01 10:58:21
date last changed
2020-01-12 06:28:27
@article{4de83db7-20fe-4217-b4b7-94af779390b3,
  abstract     = {Objective: Abnormal umbilical artery blood flow has been implicated in pregnancy complications and fetal demise. Its relation to histopathological changes in the placenta and to maternal or fetal thrombophilia is less well understood. The aim of this study was to evaluate the relation between umbilical artery Doppler findings, placental histopathology, and maternal and fetal coagulation factor V Leiden (FVL) status. Methods: Two previous studies on FVL in pregnancy made the placentas of 25 women with maternal FVL carriership and 43 randomly selected non-carriers available for a histopathological examination. Umbilical artery Doppler velocimetry was performed on 54 women in late pregnancy. Results: Abnormal umbilical artery Doppler velocimetry was associated with an approximately sevenfold increased risk of fetoplacental thrombotic vasculopathy (odds ratio [OR]: 7.5, 95% confidence intervals [CI]: 1.3-44.3), ischemic lesions (OR: 7.5, 95% CI: 1.2-46.1) and fetal carriership of FVL (OR: 8.2, 95% CI: 1.5-43.5), but not maternal FVL. Fetal FVL carriership was also associated with a sevenfold increased risk of ischemic lesions (OR: 6.7, 95% CI: 1.3-35). Conclusions: Our results indicate that the fetal - not the maternal - FVL carriership matters regarding the umbilical artery blood flow and placental pathology, which might explain some of the heterogeneity of studies.},
  author       = {Lindqvist, P. G. and Prochazka, M. and Laurini, Ricardo and Marsal, Karel},
  issn         = {1476-7058},
  language     = {eng},
  number       = {14},
  pages        = {1394--1398},
  publisher    = {Taylor & Francis},
  series       = {Journal of Maternal-Fetal & Neonatal Medicine},
  title        = {Umbilical artery Doppler in relation to placental pathology and FV Leiden in pregnant women and their offspring},
  url          = {http://dx.doi.org/10.3109/14767058.2013.791269},
  doi          = {10.3109/14767058.2013.791269},
  volume       = {26},
  year         = {2013},
}