The diagnostic and prognostic value of brain natriuretic peptides in adults with a systemic morphologically right ventricle or Fontan-type circulation.
(2007) In International Journal of Cardiology 114(3). p.345-351- Abstract
- Background: In acquired heart disease, brain natriuretic peptide (BNP) and N-Teminal pro-brain natriuretic peptide (NT-proBNP) are increasingly used as diagnostic and prognostic markers. In adult Congenital heart disease, the abnormal anatomy and physiology complicate assessment of cardiac function. We Studied the clinical correlates of measurement of natriuretic peptides (NP) in adults with a right ventricle in the systemic position or with Fontan-type physiology. Methods: A prospective longitudinal study (follow up time 23 +/- 13 months, mean +/- S.D.) was conducted in a specialised centre on 61 patients (age 26 +/- 8 years; NYHA class 1.5 +/- 0.6) including Senning/Mustard corrected transposition, congenitally corrected transposition... (More)
- Background: In acquired heart disease, brain natriuretic peptide (BNP) and N-Teminal pro-brain natriuretic peptide (NT-proBNP) are increasingly used as diagnostic and prognostic markers. In adult Congenital heart disease, the abnormal anatomy and physiology complicate assessment of cardiac function. We Studied the clinical correlates of measurement of natriuretic peptides (NP) in adults with a right ventricle in the systemic position or with Fontan-type physiology. Methods: A prospective longitudinal study (follow up time 23 +/- 13 months, mean +/- S.D.) was conducted in a specialised centre on 61 patients (age 26 +/- 8 years; NYHA class 1.5 +/- 0.6) including Senning/Mustard corrected transposition, congenitally corrected transposition and Fontan/ total cavopulmonary connection. Plasma NP concentration was compared with NYHA class, exercise capacity and echocardiographically determined systemic systolic ventricular function. Results: Neurohormone concentrations were generally elevated (mean=290% of upper reference limit) and related to NYHA class (P < 0.001, NYHA I vs. II-IV). No clinically significant relationship to ventricular function or exercise capacity was found however. An NP measurement could not predict the future Course of the disease in terms of functional status or ventricular function. Conclusion: In contrast to patients with acquired heart disease, measurement of NP seems to have low clinical value in adults with a right ventricle in the systemic position or with Fontan-type physiology. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/158308
- author
- Larsson, David LU ; Meurling, Carl LU ; Holmqvist, Fredrik LU ; Waktare, Johan E P and Thilén, Ulf LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- echocardiography, transposition, adult congenital heart disease, Fontan, grown-up congenital heart diseased, natriuretic peptides
- in
- International Journal of Cardiology
- volume
- 114
- issue
- 3
- pages
- 345 - 351
- publisher
- Elsevier
- external identifiers
-
- wos:000243241500009
- scopus:33845193371
- pmid:16777247
- ISSN
- 0167-5273
- DOI
- 10.1016/j.ijcard.2006.01.023
- language
- English
- LU publication?
- yes
- id
- 4dec15b2-4ce3-43be-b76a-acd0d85c9a1f (old id 158308)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16777247&dopt=Abstract
- date added to LUP
- 2016-04-01 12:12:41
- date last changed
- 2022-02-26 03:24:45
@article{4dec15b2-4ce3-43be-b76a-acd0d85c9a1f,
abstract = {{Background: In acquired heart disease, brain natriuretic peptide (BNP) and N-Teminal pro-brain natriuretic peptide (NT-proBNP) are increasingly used as diagnostic and prognostic markers. In adult Congenital heart disease, the abnormal anatomy and physiology complicate assessment of cardiac function. We Studied the clinical correlates of measurement of natriuretic peptides (NP) in adults with a right ventricle in the systemic position or with Fontan-type physiology. Methods: A prospective longitudinal study (follow up time 23 +/- 13 months, mean +/- S.D.) was conducted in a specialised centre on 61 patients (age 26 +/- 8 years; NYHA class 1.5 +/- 0.6) including Senning/Mustard corrected transposition, congenitally corrected transposition and Fontan/ total cavopulmonary connection. Plasma NP concentration was compared with NYHA class, exercise capacity and echocardiographically determined systemic systolic ventricular function. Results: Neurohormone concentrations were generally elevated (mean=290% of upper reference limit) and related to NYHA class (P < 0.001, NYHA I vs. II-IV). No clinically significant relationship to ventricular function or exercise capacity was found however. An NP measurement could not predict the future Course of the disease in terms of functional status or ventricular function. Conclusion: In contrast to patients with acquired heart disease, measurement of NP seems to have low clinical value in adults with a right ventricle in the systemic position or with Fontan-type physiology.}},
author = {{Larsson, David and Meurling, Carl and Holmqvist, Fredrik and Waktare, Johan E P and Thilén, Ulf}},
issn = {{0167-5273}},
keywords = {{echocardiography; transposition; adult congenital heart disease; Fontan; grown-up congenital heart diseased; natriuretic peptides}},
language = {{eng}},
number = {{3}},
pages = {{345--351}},
publisher = {{Elsevier}},
series = {{International Journal of Cardiology}},
title = {{The diagnostic and prognostic value of brain natriuretic peptides in adults with a systemic morphologically right ventricle or Fontan-type circulation.}},
url = {{https://lup.lub.lu.se/search/files/2828524/625502.pdf}},
doi = {{10.1016/j.ijcard.2006.01.023}},
volume = {{114}},
year = {{2007}},
}