Longitudinal trajectories of lifetime body shape and prostate cancer angiogenesis
Wang, Qiao-Li LU
; Song, Mingyang
; Clinton, Steven K
; Mucci, Lorelei A
; Lagergren, Jesper
and Giovannucci, Edward L
(2022)
In European Journal of Epidemiology
37(3).
p.261-270
- Abstract
Angiogenesis potentially underlies the pathway between excess adiposity and prostate carcinogenesis. This study examined the association between lifetime body shape trajectories and prostate cancer angiogenesis. 521 prostate cancer patients who underwent prostatectomy or transurethral resection between 1986 and 2000 were enrolled from the Health Professionals Follow-up Study. Cancers were immunostained and quantitated for cancer vessel regularity, diameter, area, and density, and composite angiogenesis (factor analysis). To identify distinct groups of body shape change, we conducted group-based trajectory modeling. We used multivariable linear regression to estimate the percentage difference in angiogenesis score and 95% confidence... (More)
Angiogenesis potentially underlies the pathway between excess adiposity and prostate carcinogenesis. This study examined the association between lifetime body shape trajectories and prostate cancer angiogenesis. 521 prostate cancer patients who underwent prostatectomy or transurethral resection between 1986 and 2000 were enrolled from the Health Professionals Follow-up Study. Cancers were immunostained and quantitated for cancer vessel regularity, diameter, area, and density, and composite angiogenesis (factor analysis). To identify distinct groups of body shape change, we conducted group-based trajectory modeling. We used multivariable linear regression to estimate the percentage difference in angiogenesis score and 95% confidence interval (CI) between body shape change trajectories during lifetime (age 5-60 years), early life (age 5-30 years), or later life (age 30-60 years). Compared to men with lifetime lean or medium body shape, higher angiogenesis scores were observed in men with moderate increase [percentage difference of 35% (95% CI 5-64)], marked increase [24% (95% CI - 2 to 51)], and constantly heavy with mild increase body shape [38% (95% CI 8-69)]. However, a lower angiogenesis score was noted in men with early-life marked increase (- 22%, 95% CI - 44 to 0) and stable medium body shape (- 14%, 95% CI - 40 to 12), compared to moderate increase body shape. Increased angiogenesis was also found for absolute weight gain from age 21-60 years. Lifetime body fatness accumulation, especially after age 21, was associated with increased prostate cancer angiogenesis, while weight gain in early-life adulthood was associated with lower cancer angiogenesis.
(Less)
- author
- Wang, Qiao-Li
LU
; Song, Mingyang
; Clinton, Steven K
; Mucci, Lorelei A
; Lagergren, Jesper
and Giovannucci, Edward L
- publishing date
- 2022-03
- type
- Contribution to journal
- publication status
- published
- keywords
- Adolescent, Adult, Body Mass Index, Child, Child, Preschool, Follow-Up Studies, Humans, Male, Middle Aged, Prostate, Prostatic Neoplasms, Risk Factors, Somatotypes, Weight Gain, Young Adult
- in
- European Journal of Epidemiology
- volume
- 37
- issue
- 3
- pages
- 261 - 270
- publisher
- Springer
- external identifiers
-
- scopus:85123110675
- pmid:35025021
- ISSN
- 1573-7284
- DOI
- 10.1007/s10654-021-00838-1
- language
- English
- LU publication?
- no
- additional info
- © 2022. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
- id
- 4e54c144-2a64-4ea7-a5ed-95dc18cc0597
- date added to LUP
- 2025-05-12 17:03:11
- date last changed
- 2025-07-08 09:51:31
@article{4e54c144-2a64-4ea7-a5ed-95dc18cc0597,
abstract = {{<p>Angiogenesis potentially underlies the pathway between excess adiposity and prostate carcinogenesis. This study examined the association between lifetime body shape trajectories and prostate cancer angiogenesis. 521 prostate cancer patients who underwent prostatectomy or transurethral resection between 1986 and 2000 were enrolled from the Health Professionals Follow-up Study. Cancers were immunostained and quantitated for cancer vessel regularity, diameter, area, and density, and composite angiogenesis (factor analysis). To identify distinct groups of body shape change, we conducted group-based trajectory modeling. We used multivariable linear regression to estimate the percentage difference in angiogenesis score and 95% confidence interval (CI) between body shape change trajectories during lifetime (age 5-60 years), early life (age 5-30 years), or later life (age 30-60 years). Compared to men with lifetime lean or medium body shape, higher angiogenesis scores were observed in men with moderate increase [percentage difference of 35% (95% CI 5-64)], marked increase [24% (95% CI - 2 to 51)], and constantly heavy with mild increase body shape [38% (95% CI 8-69)]. However, a lower angiogenesis score was noted in men with early-life marked increase (- 22%, 95% CI - 44 to 0) and stable medium body shape (- 14%, 95% CI - 40 to 12), compared to moderate increase body shape. Increased angiogenesis was also found for absolute weight gain from age 21-60 years. Lifetime body fatness accumulation, especially after age 21, was associated with increased prostate cancer angiogenesis, while weight gain in early-life adulthood was associated with lower cancer angiogenesis.</p>}},
author = {{Wang, Qiao-Li and Song, Mingyang and Clinton, Steven K and Mucci, Lorelei A and Lagergren, Jesper and Giovannucci, Edward L}},
issn = {{1573-7284}},
keywords = {{Adolescent; Adult; Body Mass Index; Child; Child, Preschool; Follow-Up Studies; Humans; Male; Middle Aged; Prostate; Prostatic Neoplasms; Risk Factors; Somatotypes; Weight Gain; Young Adult}},
language = {{eng}},
number = {{3}},
pages = {{261--270}},
publisher = {{Springer}},
series = {{European Journal of Epidemiology}},
title = {{Longitudinal trajectories of lifetime body shape and prostate cancer angiogenesis}},
url = {{http://dx.doi.org/10.1007/s10654-021-00838-1}},
doi = {{10.1007/s10654-021-00838-1}},
volume = {{37}},
year = {{2022}},
}