Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy)
Stefanova, N ; Lundblad, Martin LU ; Tison, F ; Poewe, W ; Cenci Nilsson, Angela LU
and Wenning, GK
(2004)
In Neurobiology of Disease
15(3).
p.630-639
- Abstract
- We examined the role of a striatal lesion in the development of L-DOPA-induced abnormal involuntary movements (AlMs) using the double lesion rat model of striatonigral degeneration (SND), the underlying neuropathological substrate of parkinsonism associated with multiple system atrophy (MSA-P), in comparison to a Parkinson's disease (PD) rat model. L-DOPA administration reliably induced AlMs in SND and PD rats in a dose-dependent fashion. AlMs occurred significantly earlier in SND compared to PD rats. There was a mild, but significant, transient increase of orolingual AlMs during the first week of low-dose L-DOPA treatment in SND. Whereas L-DOPA significantly improved contralateral forelimb akinesia in PD rats, there was no beneficial... (More)
- We examined the role of a striatal lesion in the development of L-DOPA-induced abnormal involuntary movements (AlMs) using the double lesion rat model of striatonigral degeneration (SND), the underlying neuropathological substrate of parkinsonism associated with multiple system atrophy (MSA-P), in comparison to a Parkinson's disease (PD) rat model. L-DOPA administration reliably induced AlMs in SND and PD rats in a dose-dependent fashion. AlMs occurred significantly earlier in SND compared to PD rats. There was a mild, but significant, transient increase of orolingual AlMs during the first week of low-dose L-DOPA treatment in SND. Whereas L-DOPA significantly improved contralateral forelimb akinesia in PD rats, there was no beneficial effect in SND rats. Striatal FosB/DeltaFosB up-regulation in SND and PD rats correlated with the severity of L-DOPA-induced dyskinesias. Pulsatile L-DOPA administration in the double lesion SND rat model replicates salient features of the human disease MSA-P, including loss of the anti-akinetic L-DOPA response and induction of dyskinesias with transient orolingual predominance. (C) 2004 Elsevier Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/281119
- author
- Stefanova, N
; Lundblad, Martin
LU
; Tison, F
; Poewe, W
; Cenci Nilsson, Angela
LU
and Wenning, GK
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- rat model, MSA, dyskinesia, motor improvement, levodopa, FosB
- in
- Neurobiology of Disease
- volume
- 15
- issue
- 3
- pages
- 630 - 639
- publisher
- Elsevier
- external identifiers
-
- pmid:15056471
- wos:000220796700022
- scopus:1842419375
- pmid:15056471
- ISSN
- 0969-9961
- DOI
- 10.1016/j.nbd.2003.11.025
- language
- English
- LU publication?
- yes
- id
- 4e564597-3c4f-40ca-9f84-109691121cc7 (old id 281119)
- date added to LUP
- 2016-04-01 11:54:08
- date last changed
- 2022-04-13 03:03:05
@article{4e564597-3c4f-40ca-9f84-109691121cc7,
abstract = {{We examined the role of a striatal lesion in the development of L-DOPA-induced abnormal involuntary movements (AlMs) using the double lesion rat model of striatonigral degeneration (SND), the underlying neuropathological substrate of parkinsonism associated with multiple system atrophy (MSA-P), in comparison to a Parkinson's disease (PD) rat model. L-DOPA administration reliably induced AlMs in SND and PD rats in a dose-dependent fashion. AlMs occurred significantly earlier in SND compared to PD rats. There was a mild, but significant, transient increase of orolingual AlMs during the first week of low-dose L-DOPA treatment in SND. Whereas L-DOPA significantly improved contralateral forelimb akinesia in PD rats, there was no beneficial effect in SND rats. Striatal FosB/DeltaFosB up-regulation in SND and PD rats correlated with the severity of L-DOPA-induced dyskinesias. Pulsatile L-DOPA administration in the double lesion SND rat model replicates salient features of the human disease MSA-P, including loss of the anti-akinetic L-DOPA response and induction of dyskinesias with transient orolingual predominance. (C) 2004 Elsevier Inc. All rights reserved.}},
author = {{Stefanova, N and Lundblad, Martin and Tison, F and Poewe, W and Cenci Nilsson, Angela and Wenning, GK}},
issn = {{0969-9961}},
keywords = {{rat model; MSA; dyskinesia; motor improvement; levodopa; FosB}},
language = {{eng}},
number = {{3}},
pages = {{630--639}},
publisher = {{Elsevier}},
series = {{Neurobiology of Disease}},
title = {{Effects of pulsatile L-DOPA treatment in the double lesion rat model of striatonigral degeneration (multiple system atrophy)}},
url = {{http://dx.doi.org/10.1016/j.nbd.2003.11.025}},
doi = {{10.1016/j.nbd.2003.11.025}},
volume = {{15}},
year = {{2004}},
}