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Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer

Boman, Karolina LU ; Segersten, Ulrika; Ahlgren, Göran LU ; Eberhard, Jakob LU ; Uhlén, Mathias; Jirström, Karin LU and Malmström, Per LU (2013) In BMC Urology 13(April,8). p.17-17
Abstract

BACKGROUND: Low nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to be associated with poor prognosis in several cancer forms e.g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer.

METHODS: Immunohistochemical RBM3 expression was examined in tumours from 343 patients with urothelial bladder cancer. Chi-square and Spearman's correlation tests were applied to explore associations between RBM3 expression and clinicopathological characteristics. The impact of RBM3 expression on disease-specific survival (DSS), 5-year overall survival (OS) and progression-free survival (PFS)... (More)

BACKGROUND: Low nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to be associated with poor prognosis in several cancer forms e.g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer.

METHODS: Immunohistochemical RBM3 expression was examined in tumours from 343 patients with urothelial bladder cancer. Chi-square and Spearman's correlation tests were applied to explore associations between RBM3 expression and clinicopathological characteristics. The impact of RBM3 expression on disease-specific survival (DSS), 5-year overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modelling.

RESULTS: Reduced nuclear RBM3 expression was significantly associated with more advanced tumour (T) stage (p <0.001) and high grade tumours (p=0.004). Negative RBM3 expression was associated with a significantly shorter DSS (HR=2.55; 95% CI 1.68-3.86)) and 5-year OS (HR=2.10; 95% CI 1.56-2.82), also in multivariable analysis (HR=1.65; 95% CI 1.07-2.53 for DSS and HR=1.54; 95% CI 1.13-2.10 for 5-year OS). In patients with Ta and T1 tumours expressing reduced RBM3 levels, Kaplan-Meier analysis revealed a significantly shorter PFS (p=0.048) and 5-year OS (p=0.006).

CONCLUSION: Loss of RBM3 expression is associated with clinically more aggressive tumours and an independent factor of poor prognosis in patients with urothelial bladder cancer and a potentially useful biomarker for treatment stratification and surveillance of disease progression.

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keywords
Adult, Aged, Aged, 80 and over, Biomarkers, Carcinoma, Transitional Cell, Cohort Studies, Disease Progression, Disease-Free Survival, Female, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Grading, Neoplasm Staging, Prognosis, Proportional Hazards Models, Prospective Studies, RNA-Binding Proteins, Retrospective Studies, Urinary Bladder Neoplasms, Journal Article, Research Support, Non-U.S. Gov't
in
BMC Urology
volume
13
issue
April,8
pages
17 - 17
publisher
BioMed Central
external identifiers
  • wos:000318004100001
  • pmid:23565664
  • scopus:84875819478
ISSN
1471-2490
DOI
10.1186/1471-2490-13-17
language
English
LU publication?
yes
id
4e6d98fe-9e91-48f1-a700-c206bb942398 (old id 3734030)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23565664?dopt=Abstract
date added to LUP
2013-05-04 17:15:28
date last changed
2019-01-14 07:40:07
@article{4e6d98fe-9e91-48f1-a700-c206bb942398,
  abstract     = {<p>BACKGROUND: Low nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to be associated with poor prognosis in several cancer forms e.g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer.</p><p>METHODS: Immunohistochemical RBM3 expression was examined in tumours from 343 patients with urothelial bladder cancer. Chi-square and Spearman's correlation tests were applied to explore associations between RBM3 expression and clinicopathological characteristics. The impact of RBM3 expression on disease-specific survival (DSS), 5-year overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modelling.</p><p>RESULTS: Reduced nuclear RBM3 expression was significantly associated with more advanced tumour (T) stage (p &lt;0.001) and high grade tumours (p=0.004). Negative RBM3 expression was associated with a significantly shorter DSS (HR=2.55; 95% CI 1.68-3.86)) and 5-year OS (HR=2.10; 95% CI 1.56-2.82), also in multivariable analysis (HR=1.65; 95% CI 1.07-2.53 for DSS and HR=1.54; 95% CI 1.13-2.10 for 5-year OS). In patients with Ta and T1 tumours expressing reduced RBM3 levels, Kaplan-Meier analysis revealed a significantly shorter PFS (p=0.048) and 5-year OS (p=0.006).</p><p>CONCLUSION: Loss of RBM3 expression is associated with clinically more aggressive tumours and an independent factor of poor prognosis in patients with urothelial bladder cancer and a potentially useful biomarker for treatment stratification and surveillance of disease progression.</p>},
  articleno    = {17},
  author       = {Boman, Karolina and Segersten, Ulrika and Ahlgren, Göran and Eberhard, Jakob and Uhlén, Mathias and Jirström, Karin and Malmström, Per},
  issn         = {1471-2490},
  keyword      = {Adult,Aged,Aged, 80 and over,Biomarkers,Carcinoma, Transitional Cell,Cohort Studies,Disease Progression,Disease-Free Survival,Female,Humans,Immunohistochemistry,Kaplan-Meier Estimate,Male,Middle Aged,Neoplasm Grading,Neoplasm Staging,Prognosis,Proportional Hazards Models,Prospective Studies,RNA-Binding Proteins,Retrospective Studies,Urinary Bladder Neoplasms,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {04},
  number       = {April,8},
  pages        = {17--17},
  publisher    = {BioMed Central},
  series       = {BMC Urology},
  title        = {Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer},
  url          = {http://dx.doi.org/10.1186/1471-2490-13-17},
  volume       = {13},
  year         = {2013},
}