Human B cells
Spencer, Jo ; Bemark, Mats LU
and Tull, Thomas J
(2022)
In Clinical and Experimental Immunology
210(3).
p.199-200
- Abstract
The importance of B cells and their critical role in the maintenance of health through generation of antibody-mediated immune protection is undoubted. However, the differences between the responses of B cells with different surface phenotypes in different microanatomical sites as well as diversity in B-cell function outside antibody production are just starting to be acknowledged and resolved. This series of reviews and papers that focus on human B cells will be divided across two issues. The first part of the review series in this issue captures practical information on identifying B-cell subtypes in blood in health and inflammatory diseases as well as describing aspects of B-cell diversity depending on immunoglobulin isotype and... (More)
The importance of B cells and their critical role in the maintenance of health through generation of antibody-mediated immune protection is undoubted. However, the differences between the responses of B cells with different surface phenotypes in different microanatomical sites as well as diversity in B-cell function outside antibody production are just starting to be acknowledged and resolved. This series of reviews and papers that focus on human B cells will be divided across two issues. The first part of the review series in this issue captures practical information on identifying B-cell subtypes in blood in health and inflammatory diseases as well as describing aspects of B-cell diversity depending on immunoglobulin isotype and microanatomical context. It also explores our current understanding of cytokine production by human B cells and the effect of obesity on the B-cell response. The last review in this issue will reflect on the important lessons learned from the SARS-CoV-2 pandemic; in particular the role of antigen availability and its effect on B-cell memory and antibody production.
(Less)
- author
- Spencer, Jo
; Bemark, Mats
LU
and Tull, Thomas J
- publishing date
- 2022-12-31
- type
- Contribution to journal
- publication status
- published
- keywords
- Humans, B-Lymphocytes, Immunoglobulin G, Antibodies, Viral
- in
- Clinical and Experimental Immunology
- volume
- 210
- issue
- 3
- pages
- 199 - 200
- publisher
- British Society for Immunology
- external identifiers
-
- scopus:85149999480
- pmid:36512653
- ISSN
- 0009-9104
- DOI
- 10.1093/cei/uxac110
- language
- English
- LU publication?
- no
- id
- 4ea03a95-9299-44af-8dcc-df4910d204f5
- date added to LUP
- 2023-11-16 12:33:57
- date last changed
- 2024-04-14 16:58:38
@misc{4ea03a95-9299-44af-8dcc-df4910d204f5,
abstract = {{<p>The importance of B cells and their critical role in the maintenance of health through generation of antibody-mediated immune protection is undoubted. However, the differences between the responses of B cells with different surface phenotypes in different microanatomical sites as well as diversity in B-cell function outside antibody production are just starting to be acknowledged and resolved. This series of reviews and papers that focus on human B cells will be divided across two issues. The first part of the review series in this issue captures practical information on identifying B-cell subtypes in blood in health and inflammatory diseases as well as describing aspects of B-cell diversity depending on immunoglobulin isotype and microanatomical context. It also explores our current understanding of cytokine production by human B cells and the effect of obesity on the B-cell response. The last review in this issue will reflect on the important lessons learned from the SARS-CoV-2 pandemic; in particular the role of antigen availability and its effect on B-cell memory and antibody production.</p>}},
author = {{Spencer, Jo and Bemark, Mats and Tull, Thomas J}},
issn = {{0009-9104}},
keywords = {{Humans; B-Lymphocytes; Immunoglobulin G; Antibodies, Viral}},
language = {{eng}},
month = {{12}},
number = {{3}},
pages = {{199--200}},
publisher = {{British Society for Immunology}},
series = {{Clinical and Experimental Immunology}},
title = {{Human B cells}},
url = {{http://dx.doi.org/10.1093/cei/uxac110}},
doi = {{10.1093/cei/uxac110}},
volume = {{210}},
year = {{2022}},
}