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Cyclic olefin polymers : Emerging materials for lab-on-a-chip applications

Nunes, Pedro S.; Ohlsson, Pelle D. LU ; Ordeig, Olga and Kutter, Jörg P. (2010) In Microfluidics and Nanofluidics 9(2-3). p.145-161
Abstract

Cyclic olefin polymers (COPs) are increasingly popular as substrate material for microfluidics. This is due to their promising properties, such as high chemical resistance, low water absorption, good optical transparency in the near UV range and ease of fabrication. COPs are commercially available from a range of manufacturers under various brand names (Apel, Arton, Topas, Zeonex and Zeonor). Some of these (Apel and Topas) are made from more than one kind of monomer and therefore also known as cyclic olefin copolymers (COCs). In order to structure these materials, a wide array of fabrication methods is available. Laser ablation and micromilling are direct structuring methods suitable for fast prototyping, whilst injection moulding, hot... (More)

Cyclic olefin polymers (COPs) are increasingly popular as substrate material for microfluidics. This is due to their promising properties, such as high chemical resistance, low water absorption, good optical transparency in the near UV range and ease of fabrication. COPs are commercially available from a range of manufacturers under various brand names (Apel, Arton, Topas, Zeonex and Zeonor). Some of these (Apel and Topas) are made from more than one kind of monomer and therefore also known as cyclic olefin copolymers (COCs). In order to structure these materials, a wide array of fabrication methods is available. Laser ablation and micromilling are direct structuring methods suitable for fast prototyping, whilst injection moulding, hot embossing and nanoimprint lithography are replication methods more appropriate for low-cost production. Using these fabrication methods, a multitude of chemical analysis techniques have already been implemented. These include microchip electrophoresis (MCE), chromatography, solid phase extraction (SPE), isoelectric focusing (IEF) and mass spectrometry (MS). Still much additional work is needed to characterise and utilise the full potential of COP materials. This is especially true within optofluidics, where COPs are still rarely used, despite their excellent optical properties. This review presents a detailed description of the properties of COPs, the available fabrication methods and several selected applications described in the literature.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cyclic olefin polymers, Cyclo olefin copolymers, Lab-on-a-chip, Microfluidics
in
Microfluidics and Nanofluidics
volume
9
issue
2-3
pages
17 pages
publisher
Springer
external identifiers
  • scopus:77955908299
ISSN
1613-4982
DOI
10.1007/s10404-010-0605-4
language
English
LU publication?
no
id
4ec719f3-88d2-48a9-a531-6c5139102780
date added to LUP
2017-12-06 15:15:32
date last changed
2018-07-29 04:31:17
@article{4ec719f3-88d2-48a9-a531-6c5139102780,
  abstract     = {<p>Cyclic olefin polymers (COPs) are increasingly popular as substrate material for microfluidics. This is due to their promising properties, such as high chemical resistance, low water absorption, good optical transparency in the near UV range and ease of fabrication. COPs are commercially available from a range of manufacturers under various brand names (Apel, Arton, Topas, Zeonex and Zeonor). Some of these (Apel and Topas) are made from more than one kind of monomer and therefore also known as cyclic olefin copolymers (COCs). In order to structure these materials, a wide array of fabrication methods is available. Laser ablation and micromilling are direct structuring methods suitable for fast prototyping, whilst injection moulding, hot embossing and nanoimprint lithography are replication methods more appropriate for low-cost production. Using these fabrication methods, a multitude of chemical analysis techniques have already been implemented. These include microchip electrophoresis (MCE), chromatography, solid phase extraction (SPE), isoelectric focusing (IEF) and mass spectrometry (MS). Still much additional work is needed to characterise and utilise the full potential of COP materials. This is especially true within optofluidics, where COPs are still rarely used, despite their excellent optical properties. This review presents a detailed description of the properties of COPs, the available fabrication methods and several selected applications described in the literature.</p>},
  author       = {Nunes, Pedro S. and Ohlsson, Pelle D. and Ordeig, Olga and Kutter, Jörg P.},
  issn         = {1613-4982},
  keyword      = {Cyclic olefin polymers,Cyclo olefin copolymers,Lab-on-a-chip,Microfluidics},
  language     = {eng},
  number       = {2-3},
  pages        = {145--161},
  publisher    = {Springer},
  series       = {Microfluidics and Nanofluidics},
  title        = {Cyclic olefin polymers : Emerging materials for lab-on-a-chip applications},
  url          = {http://dx.doi.org/10.1007/s10404-010-0605-4},
  volume       = {9},
  year         = {2010},
}