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Can we identify a 'high risk' patient profile to determine who will experience rapid progression of osteoarthritis?

Lohmander, L Stefan LU and Felson, David (2004) In Osteoarthritis and Cartilage 12 Suppl A. p.49-52
Abstract

Disease modifying drugs for osteoarthritis (OA) that may halt or retard joint destruction and at the same time possibly improve symptoms are being developed and tested at various stages in clinical trials. This has, for at least two reasons, focused attention on the need for identification of patient groups at high risk for incident or progressive OA. First, well characterized such groups may be useful in clinical trials. Second, assuming that disease modifying OA drugs become available in the future, primary target groups in need of such therapy have to be identified. Risk factors for incident OA may differ from those for OA progression. Interactions between risk factors for OA is little understood. Factors that have consistently been... (More)

Disease modifying drugs for osteoarthritis (OA) that may halt or retard joint destruction and at the same time possibly improve symptoms are being developed and tested at various stages in clinical trials. This has, for at least two reasons, focused attention on the need for identification of patient groups at high risk for incident or progressive OA. First, well characterized such groups may be useful in clinical trials. Second, assuming that disease modifying OA drugs become available in the future, primary target groups in need of such therapy have to be identified. Risk factors for incident OA may differ from those for OA progression. Interactions between risk factors for OA is little understood. Factors that have consistently been reported as associated with radiographic OA progression are obesity, generalized OA, alignment and synovitis. Other factors such as bone scintigraphic lesions, joint injury nad biomarkers (such as type II collagen fragments, COMP and HA) show promise. Further evaluation of these variables and their individual and combined influence will be useful to design a risk profile for OA incidence and progression.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Disease Progression, Humans, Osteoarthritis, Osteoarthritis, Knee, Patient Selection, Risk Factors
in
Osteoarthritis and Cartilage
volume
12 Suppl A
pages
49 - 52
publisher
Elsevier
external identifiers
  • Scopus:1542646908
ISSN
1063-4584
language
English
LU publication?
yes
id
4ed17732-ef94-4237-a9af-91d19c63c9b2
date added to LUP
2016-05-06 10:49:11
date last changed
2017-02-12 04:32:49
@article{4ed17732-ef94-4237-a9af-91d19c63c9b2,
  abstract     = {<p>Disease modifying drugs for osteoarthritis (OA) that may halt or retard joint destruction and at the same time possibly improve symptoms are being developed and tested at various stages in clinical trials. This has, for at least two reasons, focused attention on the need for identification of patient groups at high risk for incident or progressive OA. First, well characterized such groups may be useful in clinical trials. Second, assuming that disease modifying OA drugs become available in the future, primary target groups in need of such therapy have to be identified. Risk factors for incident OA may differ from those for OA progression. Interactions between risk factors for OA is little understood. Factors that have consistently been reported as associated with radiographic OA progression are obesity, generalized OA, alignment and synovitis. Other factors such as bone scintigraphic lesions, joint injury nad biomarkers (such as type II collagen fragments, COMP and HA) show promise. Further evaluation of these variables and their individual and combined influence will be useful to design a risk profile for OA incidence and progression.</p>},
  author       = {Lohmander, L Stefan and Felson, David},
  issn         = {1063-4584},
  keyword      = {Biomarkers,Disease Progression,Humans,Osteoarthritis,Osteoarthritis, Knee,Patient Selection,Risk Factors},
  language     = {eng},
  pages        = {49--52},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Can we identify a 'high risk' patient profile to determine who will experience rapid progression of osteoarthritis?},
  volume       = {12 Suppl A},
  year         = {2004},
}