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Discovery and refinement of loci associated with lipid levels

Willer, Cristen J.; Schmidt, Ellen M.; Sengupta, Sebanti; Peloso, Gina M.; Gustafsson, Stefan; Kanoni, Stavroula; Ganna, Andrea; Chen, Jin; Buchkovich, Martin L. and Mora, Samia, et al. (2013) In Nature Genetics 45(11). p.1274-1274
Abstract
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and... (More)
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research. (Less)
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Nature Genetics
volume
45
issue
11
pages
1274 - 1274
publisher
Nature Publishing Group
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  • wos:000326384100007
  • scopus:84887099827
ISSN
1546-1718
DOI
10.1038/ng.2797
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English
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yes
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4f07f785-c869-40bb-9154-2164c325b5a9 (old id 4204583)
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2014-01-03 10:42:05
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2018-12-09 03:42:15
@article{4f07f785-c869-40bb-9154-2164c325b5a9,
  abstract     = {Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P &lt; 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.},
  author       = {Willer, Cristen J. and Schmidt, Ellen M. and Sengupta, Sebanti and Peloso, Gina M. and Gustafsson, Stefan and Kanoni, Stavroula and Ganna, Andrea and Chen, Jin and Buchkovich, Martin L. and Mora, Samia and Beckmann, Jacques S. and Bragg-Gresham, Jennifer L. and Chang, Hsing-Yi and Demirkan, Ayse and Den Hertog, Heleen M. and Do, Ron and Donnelly, Louise A. and Ehret, Georg B. and Esko, Tonu and Feitosa, Mary F. and Ferreira, Teresa and Fischer, Krista and Fontanillas, Pierre and Fraser, Ross M. and Freitag, Daniel F. and Gurdasani, Deepti and Heikkila, Kauko and Hyppoenen, Elina and Isaacs, Aaron and Jackson, Anne U. and Johansson, Asa and Johnson, Toby and Kaakinen, Marika and Kettunen, Johannes and Kleber, Marcus E. and Li, Xiaohui and Luan, Jian'an and Lyytikainen, Leo-Pekka and Magnusson, Patrik K. E. and Mangino, Massimo and Mihailov, Evelin and Montasser, May E. and Mueller-Nurasyid, Martina and Nolte, Ilja M. and O'Connell, Jeffrey R. and Palmer, Cameron D. and Perola, Markus and Petersen, Ann-Kristin and Sanna, Serena and Saxena, Richa and Service, Susan K. and Shah, Sonia and Shungin, Dmitry and Sidore, Carlo and Song, Ci and Strawbridge, Rona J. and Surakka, Ida and Tanaka, Toshiko and Teslovich, Tanya M. and Thorleifsson, Gudmar and Van den Herik, Evita G. and Voight, Benjamin F. and Volcik, Kelly A. and Waite, Lindsay L. and Wong, Andrew and Wu, Ying and Zhang, Weihua and Absher, Devin and Asiki, Gershim and Barroso, Ines and Been, Latonya F. and Bolton, Jennifer L. and Bonnycastle, Lori L. and Brambilla, Paolo and Burnett, Mary S. and Cesana, Giancarlo and Dimitriou, Maria and Doney, Alex S. 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  issn         = {1546-1718},
  language     = {eng},
  number       = {11},
  pages        = {1274--1274},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Discovery and refinement of loci associated with lipid levels},
  url          = {http://dx.doi.org/10.1038/ng.2797},
  volume       = {45},
  year         = {2013},
}