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Effect of low-molecular-weight heparin (Tinzaparin) and unfractionated heparin on platelet aggregation

Ravn, Hanne B.; Bregengaard, Claus; Vissinger, Henrik; Østergaard, Per; Holst, Jan LU ; Nielsen, Hans K.; Kristensen, Steen D. and Husted, Steen E. (1996) In Clinical and Applied Thrombosis/Hemostasis 2(3). p.209-212
Abstract

A low-molecular-weight heparin (LMWH), Tinzaparin, was compared with unfractionated heparin (UFH) for their effects on platelet aggregation in vitro and ex vivo. Both heparins showed a dose-dependent proaggregatory effect on ADP- and collagen-induced platelet aggregation in vitro, but LMWH was less potent. The differences in potency between Tinzaparin and UFH depended on how the compounds were compared. The most pronounced difference was found when molar concentrations were used for comparison; the smallest was found when anti-IIa activity was compared. In the ex vivo part of the study, a significant enhancement of ADP-induced platelet aggregation was observed after i.v. administration of both Tinzaparin and UFH with no difference in... (More)

A low-molecular-weight heparin (LMWH), Tinzaparin, was compared with unfractionated heparin (UFH) for their effects on platelet aggregation in vitro and ex vivo. Both heparins showed a dose-dependent proaggregatory effect on ADP- and collagen-induced platelet aggregation in vitro, but LMWH was less potent. The differences in potency between Tinzaparin and UFH depended on how the compounds were compared. The most pronounced difference was found when molar concentrations were used for comparison; the smallest was found when anti-IIa activity was compared. In the ex vivo part of the study, a significant enhancement of ADP-induced platelet aggregation was observed after i.v. administration of both Tinzaparin and UFH with no difference in potency. Subcutaneous administration of Tinzaparin in two different doses did not have any effect on platelet activity. In conclusion, Tinzaparin appears, like other LMWHs, to have less proaggregatory effect on platelets than UFH both in vitro and ex vivo.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Human, LMWH, Platelet aggregation, Unfractionated heparin
in
Clinical and Applied Thrombosis/Hemostasis
volume
2
issue
3
pages
209 - 212
publisher
SAGE Publications Inc.
external identifiers
  • scopus:24044515927
ISSN
1076-0296
DOI
10.1177/107602969600200311
language
English
LU publication?
no
id
4f59ee5c-979a-4509-845e-4cb482a42357
date added to LUP
2018-04-06 13:35:07
date last changed
2018-11-21 21:39:07
@article{4f59ee5c-979a-4509-845e-4cb482a42357,
  abstract     = {<p>A low-molecular-weight heparin (LMWH), Tinzaparin, was compared with unfractionated heparin (UFH) for their effects on platelet aggregation in vitro and ex vivo. Both heparins showed a dose-dependent proaggregatory effect on ADP- and collagen-induced platelet aggregation in vitro, but LMWH was less potent. The differences in potency between Tinzaparin and UFH depended on how the compounds were compared. The most pronounced difference was found when molar concentrations were used for comparison; the smallest was found when anti-IIa activity was compared. In the ex vivo part of the study, a significant enhancement of ADP-induced platelet aggregation was observed after i.v. administration of both Tinzaparin and UFH with no difference in potency. Subcutaneous administration of Tinzaparin in two different doses did not have any effect on platelet activity. In conclusion, Tinzaparin appears, like other LMWHs, to have less proaggregatory effect on platelets than UFH both in vitro and ex vivo.</p>},
  author       = {Ravn, Hanne B. and Bregengaard, Claus and Vissinger, Henrik and Østergaard, Per and Holst, Jan and Nielsen, Hans K. and Kristensen, Steen D. and Husted, Steen E.},
  issn         = {1076-0296},
  keyword      = {Human,LMWH,Platelet aggregation,Unfractionated heparin},
  language     = {eng},
  number       = {3},
  pages        = {209--212},
  publisher    = {SAGE Publications Inc.},
  series       = {Clinical and Applied Thrombosis/Hemostasis},
  title        = {Effect of low-molecular-weight heparin (Tinzaparin) and unfractionated heparin on platelet aggregation},
  url          = {http://dx.doi.org/10.1177/107602969600200311},
  volume       = {2},
  year         = {1996},
}