Effect of low-molecular-weight heparin (Tinzaparin) and unfractionated heparin on platelet aggregation
(1996) In Clinical and Applied Thrombosis/Hemostasis 2(3). p.209-212- Abstract
A low-molecular-weight heparin (LMWH), Tinzaparin, was compared with unfractionated heparin (UFH) for their effects on platelet aggregation in vitro and ex vivo. Both heparins showed a dose-dependent proaggregatory effect on ADP- and collagen-induced platelet aggregation in vitro, but LMWH was less potent. The differences in potency between Tinzaparin and UFH depended on how the compounds were compared. The most pronounced difference was found when molar concentrations were used for comparison; the smallest was found when anti-IIa activity was compared. In the ex vivo part of the study, a significant enhancement of ADP-induced platelet aggregation was observed after i.v. administration of both Tinzaparin and UFH with no difference in... (More)
A low-molecular-weight heparin (LMWH), Tinzaparin, was compared with unfractionated heparin (UFH) for their effects on platelet aggregation in vitro and ex vivo. Both heparins showed a dose-dependent proaggregatory effect on ADP- and collagen-induced platelet aggregation in vitro, but LMWH was less potent. The differences in potency between Tinzaparin and UFH depended on how the compounds were compared. The most pronounced difference was found when molar concentrations were used for comparison; the smallest was found when anti-IIa activity was compared. In the ex vivo part of the study, a significant enhancement of ADP-induced platelet aggregation was observed after i.v. administration of both Tinzaparin and UFH with no difference in potency. Subcutaneous administration of Tinzaparin in two different doses did not have any effect on platelet activity. In conclusion, Tinzaparin appears, like other LMWHs, to have less proaggregatory effect on platelets than UFH both in vitro and ex vivo.
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- author
- Ravn, Hanne B. ; Bregengaard, Claus ; Vissinger, Henrik ; Østergaard, Per ; Holst, Jan LU ; Nielsen, Hans K. ; Kristensen, Steen D. and Husted, Steen E.
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- keywords
- Human, LMWH, Platelet aggregation, Unfractionated heparin
- in
- Clinical and Applied Thrombosis/Hemostasis
- volume
- 2
- issue
- 3
- pages
- 209 - 212
- publisher
- SAGE Publications
- external identifiers
-
- scopus:24044515927
- ISSN
- 1076-0296
- DOI
- 10.1177/107602969600200311
- language
- English
- LU publication?
- no
- id
- 4f59ee5c-979a-4509-845e-4cb482a42357
- date added to LUP
- 2018-04-06 13:35:07
- date last changed
- 2022-01-31 02:46:11
@article{4f59ee5c-979a-4509-845e-4cb482a42357, abstract = {{<p>A low-molecular-weight heparin (LMWH), Tinzaparin, was compared with unfractionated heparin (UFH) for their effects on platelet aggregation in vitro and ex vivo. Both heparins showed a dose-dependent proaggregatory effect on ADP- and collagen-induced platelet aggregation in vitro, but LMWH was less potent. The differences in potency between Tinzaparin and UFH depended on how the compounds were compared. The most pronounced difference was found when molar concentrations were used for comparison; the smallest was found when anti-IIa activity was compared. In the ex vivo part of the study, a significant enhancement of ADP-induced platelet aggregation was observed after i.v. administration of both Tinzaparin and UFH with no difference in potency. Subcutaneous administration of Tinzaparin in two different doses did not have any effect on platelet activity. In conclusion, Tinzaparin appears, like other LMWHs, to have less proaggregatory effect on platelets than UFH both in vitro and ex vivo.</p>}}, author = {{Ravn, Hanne B. and Bregengaard, Claus and Vissinger, Henrik and Østergaard, Per and Holst, Jan and Nielsen, Hans K. and Kristensen, Steen D. and Husted, Steen E.}}, issn = {{1076-0296}}, keywords = {{Human; LMWH; Platelet aggregation; Unfractionated heparin}}, language = {{eng}}, number = {{3}}, pages = {{209--212}}, publisher = {{SAGE Publications}}, series = {{Clinical and Applied Thrombosis/Hemostasis}}, title = {{Effect of low-molecular-weight heparin (Tinzaparin) and unfractionated heparin on platelet aggregation}}, url = {{http://dx.doi.org/10.1177/107602969600200311}}, doi = {{10.1177/107602969600200311}}, volume = {{2}}, year = {{1996}}, }