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International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems

Hyland, C.A. ; Olsson, M.L. LU orcid ; Storry, J.R. LU ; V., Yahalom and Gassner, Christoph (2026) In Vox Sanguinis 121(2). p.202-212
Abstract
Background and Objectives: The International Society of Blood Transfusion (ISBT) Working Party (WP) on Red Cell Immunogenetics and Blood Group Terminology (RCI&BGT) held six business meetings between December 2021 and June 2024. This report describes the new blood group systems and antigens ratified during these meetings. Materials and Methods: Candidate systems and antigens were reviewed according to serological, genetic and biological evidence. This evidence was matched against defined criteria, and the acknowledged systems/antigens were assigned a unique identifier. Results: Four new systems, ER (ISBT 044), CD36 (ISBT 045), ATP11C (ISBT 046) and MAL (ISBT 047), were ratified. CD36 and ATP11C were de novo entries, while ER and MAL... (More)
Background and Objectives: The International Society of Blood Transfusion (ISBT) Working Party (WP) on Red Cell Immunogenetics and Blood Group Terminology (RCI&BGT) held six business meetings between December 2021 and June 2024. This report describes the new blood group systems and antigens ratified during these meetings. Materials and Methods: Candidate systems and antigens were reviewed according to serological, genetic and biological evidence. This evidence was matched against defined criteria, and the acknowledged systems/antigens were assigned a unique identifier. Results: Four new systems, ER (ISBT 044), CD36 (ISBT 045), ATP11C (ISBT 046) and MAL (ISBT 047), were ratified. CD36 and ATP11C were de novo entries, while ER and MAL systems resolved the genetic basis for the Er and AnWj antigens. Thirteen antigens were added to existing systems: one each to LU (005), YT (011), SC (013), LW (016), KN (022), GLOB (028); an antithetical pair to KEL (006); two antigens to RHAG (030); and three to CTL2 (039). Two CTL2 antigens defined the hitherto unresolved antithetical antigens, Csa/Csb, whose genetic basis coincides with those of variants responsible for the HNA-3a/3b neutrophil antigens, respectively. Conclusion: As of June 2024, the ISBT has acknowledged 47 blood group systems, comprising 366 antigens. The WP continues to ratify new systems and antigens, which are available on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/). © 2025 International Society of Blood Transfusion. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
blood groups, genetics, genomics, red cell antigens, terminology, Blood Group Antigens, Blood Grouping and Crossmatching, Blood Transfusion, Erythrocytes, Humans, Immunogenetics, Spain, Terminology as Topic, blood group antigen, blood group typing, blood transfusion, classification, erythrocyte, human, immunogenetics, immunology, nomenclature
in
Vox Sanguinis
volume
121
issue
2
pages
11 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:105023514130
ISSN
0042-9007
DOI
10.1111/vox.70148
language
English
LU publication?
yes
id
4f60da4a-a768-4722-b4e3-43e52be388b1
date added to LUP
2026-03-24 12:25:52
date last changed
2026-03-24 12:26:09
@article{4f60da4a-a768-4722-b4e3-43e52be388b1,
  abstract     = {{Background and Objectives: The International Society of Blood Transfusion (ISBT) Working Party (WP) on Red Cell Immunogenetics and Blood Group Terminology (RCI&BGT) held six business meetings between December 2021 and June 2024. This report describes the new blood group systems and antigens ratified during these meetings. Materials and Methods: Candidate systems and antigens were reviewed according to serological, genetic and biological evidence. This evidence was matched against defined criteria, and the acknowledged systems/antigens were assigned a unique identifier. Results: Four new systems, ER (ISBT 044), CD36 (ISBT 045), ATP11C (ISBT 046) and MAL (ISBT 047), were ratified. CD36 and ATP11C were de novo entries, while ER and MAL systems resolved the genetic basis for the Er and AnWj antigens. Thirteen antigens were added to existing systems: one each to LU (005), YT (011), SC (013), LW (016), KN (022), GLOB (028); an antithetical pair to KEL (006); two antigens to RHAG (030); and three to CTL2 (039). Two CTL2 antigens defined the hitherto unresolved antithetical antigens, Csa/Csb, whose genetic basis coincides with those of variants responsible for the HNA-3a/3b neutrophil antigens, respectively. Conclusion: As of June 2024, the ISBT has acknowledged 47 blood group systems, comprising 366 antigens. The WP continues to ratify new systems and antigens, which are available on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/). © 2025 International Society of Blood Transfusion.}},
  author       = {{Hyland, C.A. and Olsson, M.L. and Storry, J.R. and V., Yahalom and Gassner, Christoph}},
  issn         = {{0042-9007}},
  keywords     = {{blood groups; genetics; genomics; red cell antigens; terminology; Blood Group Antigens; Blood Grouping and Crossmatching; Blood Transfusion; Erythrocytes; Humans; Immunogenetics; Spain; Terminology as Topic; blood group antigen; blood group typing; blood transfusion; classification; erythrocyte; human; immunogenetics; immunology; nomenclature}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{202--212}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Vox Sanguinis}},
  title        = {{International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Gothenburg, Barcelona and four virtual business meetings: Update on blood group systems}},
  url          = {{http://dx.doi.org/10.1111/vox.70148}},
  doi          = {{10.1111/vox.70148}},
  volume       = {{121}},
  year         = {{2026}},
}