Smart platform for development of small-scale integrated continuous downstream processes
(2022) In Advances in Chemical Engineering 59(1). p.131-158- Abstract
This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are automated and controlled by the external supervisory controller, called Orbit. Orbit communicate with the local equipment control system, resulting in a minimum of adjustment in the laboratory infrastructure. Orbit is implemented in python, making it an open, flexible, and extendable control system. Orbit give support for integration of multiple... (More)
This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are automated and controlled by the external supervisory controller, called Orbit. Orbit communicate with the local equipment control system, resulting in a minimum of adjustment in the laboratory infrastructure. Orbit is implemented in python, making it an open, flexible, and extendable control system. Orbit give support for integration of multiple chromatography columns, operate downstream processes on multiple parallel setups, integrated online analytics, use of advanced feedback control and batch-to-batch control. This functionality is presented in ten examples. The platform has successful been used in number of industrial case studies, particular in early drug and process development and for efficient small-scale drug candidate production.
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- author
- Andersson, Niklas LU ; Gomis Fons, Joaquín LU and Nilsson, Bernt LU
- organization
- publishing date
- 2022
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Continuous downstream processing, Flexible process development platform, Integrated online analytics, Process automation and control, Process integration
- host publication
- Advances in Chemical Engineering
- series title
- Advances in Chemical Engineering
- volume
- 59
- issue
- 1
- pages
- 28 pages
- publisher
- Academic Press
- external identifiers
-
- scopus:85128606983
- ISSN
- 0065-2377
- DOI
- 10.1016/bs.ache.2022.03.004
- language
- English
- LU publication?
- yes
- id
- 4f89a786-4de9-4d8a-b9db-7ebfefcc9e52
- date added to LUP
- 2022-06-29 14:41:51
- date last changed
- 2023-12-19 20:12:01
@inbook{4f89a786-4de9-4d8a-b9db-7ebfefcc9e52, abstract = {{<p>This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are automated and controlled by the external supervisory controller, called Orbit. Orbit communicate with the local equipment control system, resulting in a minimum of adjustment in the laboratory infrastructure. Orbit is implemented in python, making it an open, flexible, and extendable control system. Orbit give support for integration of multiple chromatography columns, operate downstream processes on multiple parallel setups, integrated online analytics, use of advanced feedback control and batch-to-batch control. This functionality is presented in ten examples. The platform has successful been used in number of industrial case studies, particular in early drug and process development and for efficient small-scale drug candidate production.</p>}}, author = {{Andersson, Niklas and Gomis Fons, Joaquín and Nilsson, Bernt}}, booktitle = {{Advances in Chemical Engineering}}, issn = {{0065-2377}}, keywords = {{Continuous downstream processing; Flexible process development platform; Integrated online analytics; Process automation and control; Process integration}}, language = {{eng}}, number = {{1}}, pages = {{131--158}}, publisher = {{Academic Press}}, series = {{Advances in Chemical Engineering}}, title = {{Smart platform for development of small-scale integrated continuous downstream processes}}, url = {{http://dx.doi.org/10.1016/bs.ache.2022.03.004}}, doi = {{10.1016/bs.ache.2022.03.004}}, volume = {{59}}, year = {{2022}}, }