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Smart platform for development of small-scale integrated continuous downstream processes

Andersson, Niklas LU orcid ; Gomis Fons, Joaquín LU and Nilsson, Bernt LU (2022) In Advances in Chemical Engineering 59(1). p.131-158
Abstract

This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are automated and controlled by the external supervisory controller, called Orbit. Orbit communicate with the local equipment control system, resulting in a minimum of adjustment in the laboratory infrastructure. Orbit is implemented in python, making it an open, flexible, and extendable control system. Orbit give support for integration of multiple... (More)

This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are automated and controlled by the external supervisory controller, called Orbit. Orbit communicate with the local equipment control system, resulting in a minimum of adjustment in the laboratory infrastructure. Orbit is implemented in python, making it an open, flexible, and extendable control system. Orbit give support for integration of multiple chromatography columns, operate downstream processes on multiple parallel setups, integrated online analytics, use of advanced feedback control and batch-to-batch control. This functionality is presented in ten examples. The platform has successful been used in number of industrial case studies, particular in early drug and process development and for efficient small-scale drug candidate production.

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Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Continuous downstream processing, Flexible process development platform, Integrated online analytics, Process automation and control, Process integration
host publication
Advances in Chemical Engineering
series title
Advances in Chemical Engineering
volume
59
issue
1
pages
28 pages
publisher
Academic Press
external identifiers
  • scopus:85128606983
ISSN
0065-2377
DOI
10.1016/bs.ache.2022.03.004
language
English
LU publication?
yes
id
4f89a786-4de9-4d8a-b9db-7ebfefcc9e52
date added to LUP
2022-06-29 14:41:51
date last changed
2023-12-19 20:12:01
@inbook{4f89a786-4de9-4d8a-b9db-7ebfefcc9e52,
  abstract     = {{<p>This chapter presents and discuss a platform for small-scale drug candidate production, process development and performance studies of integrated continuous downstream processes. The main idea of the platform methodology is to use common available equipment and reconfigure them for advanced downstream processing. Five different industrial case studies are discussed. The resulting processes are automated and controlled by the external supervisory controller, called Orbit. Orbit communicate with the local equipment control system, resulting in a minimum of adjustment in the laboratory infrastructure. Orbit is implemented in python, making it an open, flexible, and extendable control system. Orbit give support for integration of multiple chromatography columns, operate downstream processes on multiple parallel setups, integrated online analytics, use of advanced feedback control and batch-to-batch control. This functionality is presented in ten examples. The platform has successful been used in number of industrial case studies, particular in early drug and process development and for efficient small-scale drug candidate production.</p>}},
  author       = {{Andersson, Niklas and Gomis Fons, Joaquín and Nilsson, Bernt}},
  booktitle    = {{Advances in Chemical Engineering}},
  issn         = {{0065-2377}},
  keywords     = {{Continuous downstream processing; Flexible process development platform; Integrated online analytics; Process automation and control; Process integration}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{131--158}},
  publisher    = {{Academic Press}},
  series       = {{Advances in Chemical Engineering}},
  title        = {{Smart platform for development of small-scale integrated continuous downstream processes}},
  url          = {{http://dx.doi.org/10.1016/bs.ache.2022.03.004}},
  doi          = {{10.1016/bs.ache.2022.03.004}},
  volume       = {{59}},
  year         = {{2022}},
}