The spatial QRS-T angle outperforms the Italian and Seattle ECG-based criteria for detection of hypertrophic cardiomyopathy in pediatric patients
(2015) In Journal of Electrocardiology 48(5). p.826-833- Abstract
Introduction The spatial peaks QRS-T angle has been shown to differentiate adult patients with hypertrophic cardiomyopathy (HCM) from controls. We hypothesized that the spatial peaks QRS-T angle would, in isolation, be more accurate than the Italian 12-lead ECG Pre-participation Screening criteria or the Seattle criteria for detecting hypertrophic cardiomyopathy (HCM) in pediatric patients. Methods A retrospective study of pediatric patients with HCM compared to age and gender-matched control patients was undertaken. Significance, odds ratios, sensitivity and specificity of HCM detection of the visually derived spatial peaks QRS-T angle were compared to those of traditional 12-lead ECG criteria using: 1) Italy's National... (More)
Introduction The spatial peaks QRS-T angle has been shown to differentiate adult patients with hypertrophic cardiomyopathy (HCM) from controls. We hypothesized that the spatial peaks QRS-T angle would, in isolation, be more accurate than the Italian 12-lead ECG Pre-participation Screening criteria or the Seattle criteria for detecting hypertrophic cardiomyopathy (HCM) in pediatric patients. Methods A retrospective study of pediatric patients with HCM compared to age and gender-matched control patients was undertaken. Significance, odds ratios, sensitivity and specificity of HCM detection of the visually derived spatial peaks QRS-T angle were compared to those of traditional 12-lead ECG criteria using: 1) Italy's National Pre-participation Screening Programme criteria; and 2) described criteria from Seattle. Results ECG results from 130 pediatric HCM patients (14.2 ± 4.4 years) were compared to 470 control patients (normal echocardiograms, mean age 13.4 ± 4.6 years). Mean ± standard deviation (SD) values for spatial peaks QRS-T angles were 120.4 ± 40.7 and 21.3 ± 13.7 degrees for HCM and controls, respectively (P < 0.001). A spatial peaks QRS-T angle cutoff value of > 54.9 degrees yielded greater sensitivity and specificity (93.1% and 98.7%, respectively) for detecting HCM over ECG criteria from Italy (68.5% and 48.1%, respectively) or Seattle (64.6% and 78.9%, respectively) with odds ratios at 1039.70 (95% CI 363.03 to 2977.67), 2.01 (95% CI 1.33 to 3.04) and 6.84 (4.49-10.44), respectively. Conclusion In our cohort, a visually derived spatial peaks QRS-T angle has increased sensitivity and specificity for detection of HCM in pediatric patients compared to currently utilized Italian or Seattle ECG criteria.
(Less)
- author
- publishing date
- 2015-09-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Italian criteria, Screening, Seattle criteria, Vectorcardiography
- in
- Journal of Electrocardiology
- volume
- 48
- issue
- 5
- pages
- 8 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:84941314078
- ISSN
- 0022-0736
- DOI
- 10.1016/j.jelectrocard.2015.07.016
- language
- English
- LU publication?
- no
- id
- 4f89c752-f6c4-4c27-bc4d-82b98f4ee02e
- date added to LUP
- 2017-08-29 12:07:47
- date last changed
- 2022-04-01 19:02:56
@article{4f89c752-f6c4-4c27-bc4d-82b98f4ee02e,
abstract = {{<p>Introduction The spatial peaks QRS-T angle has been shown to differentiate adult patients with hypertrophic cardiomyopathy (HCM) from controls. We hypothesized that the spatial peaks QRS-T angle would, in isolation, be more accurate than the Italian 12-lead ECG Pre-participation Screening criteria or the Seattle criteria for detecting hypertrophic cardiomyopathy (HCM) in pediatric patients. Methods A retrospective study of pediatric patients with HCM compared to age and gender-matched control patients was undertaken. Significance, odds ratios, sensitivity and specificity of HCM detection of the visually derived spatial peaks QRS-T angle were compared to those of traditional 12-lead ECG criteria using: 1) Italy's National Pre-participation Screening Programme criteria; and 2) described criteria from Seattle. Results ECG results from 130 pediatric HCM patients (14.2 ± 4.4 years) were compared to 470 control patients (normal echocardiograms, mean age 13.4 ± 4.6 years). Mean ± standard deviation (SD) values for spatial peaks QRS-T angles were 120.4 ± 40.7 and 21.3 ± 13.7 degrees for HCM and controls, respectively (P < 0.001). A spatial peaks QRS-T angle cutoff value of > 54.9 degrees yielded greater sensitivity and specificity (93.1% and 98.7%, respectively) for detecting HCM over ECG criteria from Italy (68.5% and 48.1%, respectively) or Seattle (64.6% and 78.9%, respectively) with odds ratios at 1039.70 (95% CI 363.03 to 2977.67), 2.01 (95% CI 1.33 to 3.04) and 6.84 (4.49-10.44), respectively. Conclusion In our cohort, a visually derived spatial peaks QRS-T angle has increased sensitivity and specificity for detection of HCM in pediatric patients compared to currently utilized Italian or Seattle ECG criteria.</p>}},
author = {{Cortez, Daniel and Sharma, Nandita and Cavanaugh, Jean and Tuozo, Froilan and Derk, Gwendolyn and Lundberg, Emily and Schlegel, Todd T and Weiner, Keith and Kiciman, Nafiz and Alejos, Juan and Landeck, Bruce and Aboulhosn, Jamil and Miyamoto, Shelley and Batra, Anjan S. and McCanta, Anthony C.}},
issn = {{0022-0736}},
keywords = {{Italian criteria; Screening; Seattle criteria; Vectorcardiography}},
language = {{eng}},
month = {{09}},
number = {{5}},
pages = {{826--833}},
publisher = {{Elsevier}},
series = {{Journal of Electrocardiology}},
title = {{The spatial QRS-T angle outperforms the Italian and Seattle ECG-based criteria for detection of hypertrophic cardiomyopathy in pediatric patients}},
url = {{http://dx.doi.org/10.1016/j.jelectrocard.2015.07.016}},
doi = {{10.1016/j.jelectrocard.2015.07.016}},
volume = {{48}},
year = {{2015}},
}