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Diabetes is associated with increased hand pain in erosive hand osteoarthritis : data from a population-based study

Magnusson, Karin LU ; Hagen, Kåre Birger; Østerås, Nina; Nordsletten, Lars; Natvig, Bård and Haugen, Ida K (2015) In Arthritis Care and Research1988-01-01+01:002000-01-01+01:00 67(2). p.95-187
Abstract

OBJECTIVE: To explore factors related to hand pain in persons with radiographic hand osteoarthritis (OA).

METHODS: Persons in the Musculoskeletal Pain in Ullensaker Study with radiographic hand OA (≥1 joint with Kellgren/Lawrence grade ≥2) were included (n = 530). We examined the cross-sectional association between possible explanatory variables and hand pain in the entire sample and in 2 hand OA phenotypes (erosive versus nonerosive) using structural equation analyses. Outcome variables were the Australian/Canadian Hand Osteoarthritis Index (AUSCAN; range 0-20) and number of tender finger joints upon palpation (NTJ; range 0-30).

RESULTS: The mean age was 65 years (40-79 years) and 375 participants were women (71%). Diabetes... (More)

OBJECTIVE: To explore factors related to hand pain in persons with radiographic hand osteoarthritis (OA).

METHODS: Persons in the Musculoskeletal Pain in Ullensaker Study with radiographic hand OA (≥1 joint with Kellgren/Lawrence grade ≥2) were included (n = 530). We examined the cross-sectional association between possible explanatory variables and hand pain in the entire sample and in 2 hand OA phenotypes (erosive versus nonerosive) using structural equation analyses. Outcome variables were the Australian/Canadian Hand Osteoarthritis Index (AUSCAN; range 0-20) and number of tender finger joints upon palpation (NTJ; range 0-30).

RESULTS: The mean age was 65 years (40-79 years) and 375 participants were women (71%). Diabetes mellitus, female sex, lower education status, familial OA, infrequent alcohol drinking, widespread pain, poor mental health, and higher number of finger joints with ultrasound-detected synovitis and radiographic OA were related to more hand pain in the entire sample. Stratified analyses showed that diabetes mellitus was strongly associated with AUSCAN pain (B-unstandardized coefficient = 3.81 [95% confidence interval (95% CI) 2.27, 5.35]) and NTJ (B-unstandardized coefficient = 4.16 [95% CI 2.01, 6.31]) in erosive hand OA only. In nonerosive OA, lower education status, having familial OA, and poor mental health were associated with hand OA pain. Widespread pain was associated with both outcomes in both phenotypes.

CONCLUSION: Structural and inflammatory OA changes as well as demographic factors, psychosocial factors, and diabetes mellitus were associated with pain in hand OA. The strong association between diabetes mellitus and pain in erosive hand OA should be further explored.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Animals, Cross-Sectional Studies, Diabetes Complications, Diabetes Mellitus, Female, Finger Joint, Hand, Humans, Male, Middle Aged, Osteoarthritis, Pain, Psychology, Journal Article, Research Support, Non-U.S. Gov't
in
Arthritis Care and Research1988-01-01+01:002000-01-01+01:00
volume
67
issue
2
pages
9 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:84922068400
ISSN
0893-7524
DOI
10.1002/acr.22460
language
English
LU publication?
no
id
4f9d08f2-84fb-42ba-8a75-5483369e2f95
date added to LUP
2017-05-07 17:37:06
date last changed
2017-11-12 04:31:39
@article{4f9d08f2-84fb-42ba-8a75-5483369e2f95,
  abstract     = {<p>OBJECTIVE: To explore factors related to hand pain in persons with radiographic hand osteoarthritis (OA).</p><p>METHODS: Persons in the Musculoskeletal Pain in Ullensaker Study with radiographic hand OA (≥1 joint with Kellgren/Lawrence grade ≥2) were included (n = 530). We examined the cross-sectional association between possible explanatory variables and hand pain in the entire sample and in 2 hand OA phenotypes (erosive versus nonerosive) using structural equation analyses. Outcome variables were the Australian/Canadian Hand Osteoarthritis Index (AUSCAN; range 0-20) and number of tender finger joints upon palpation (NTJ; range 0-30).</p><p>RESULTS: The mean age was 65 years (40-79 years) and 375 participants were women (71%). Diabetes mellitus, female sex, lower education status, familial OA, infrequent alcohol drinking, widespread pain, poor mental health, and higher number of finger joints with ultrasound-detected synovitis and radiographic OA were related to more hand pain in the entire sample. Stratified analyses showed that diabetes mellitus was strongly associated with AUSCAN pain (B-unstandardized coefficient = 3.81 [95% confidence interval (95% CI) 2.27, 5.35]) and NTJ (B-unstandardized coefficient = 4.16 [95% CI 2.01, 6.31]) in erosive hand OA only. In nonerosive OA, lower education status, having familial OA, and poor mental health were associated with hand OA pain. Widespread pain was associated with both outcomes in both phenotypes.</p><p>CONCLUSION: Structural and inflammatory OA changes as well as demographic factors, psychosocial factors, and diabetes mellitus were associated with pain in hand OA. The strong association between diabetes mellitus and pain in erosive hand OA should be further explored.</p>},
  author       = {Magnusson, Karin and Hagen, Kåre Birger and Østerås, Nina and Nordsletten, Lars and Natvig, Bård and Haugen, Ida K},
  issn         = {0893-7524},
  keyword      = {Adult,Animals,Cross-Sectional Studies,Diabetes Complications,Diabetes Mellitus,Female,Finger Joint,Hand,Humans,Male,Middle Aged,Osteoarthritis,Pain,Psychology,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {2},
  pages        = {95--187},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis Care and Research1988-01-01+01:002000-01-01+01:00},
  title        = {Diabetes is associated with increased hand pain in erosive hand osteoarthritis : data from a population-based study},
  url          = {http://dx.doi.org/10.1002/acr.22460},
  volume       = {67},
  year         = {2015},
}