Nasal polyposis is a risk factor for nonadherence to CPAP treatment in sleep apnea : the population-based DISCOVERY study
Bengtsson, Caroline ; Grote, Ludger ; Ljunggren, Mirjam ; Ekström, Magnus LU
and Palm, Andreas
(2023)
In Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
19(3).
p.573-579
- Abstract
STUDY OBJECTIVES: The aim was to evaluate nasal polyposis as a risk factor for nonadherence to continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA). METHODS: This was a population-based, longitudinal analysis of patients starting CPAP treatment for OSA in the Swedish quality registry Swedevox between 2010 and 2018. Data were cross-linked with national registries. The impact of nasal polyposis on CPAP adherence was analyzed using uni- and multivariable logistic and linear regression models. Relevant confounders (age, sex, usage of nasal and oral steroids) were identified using a direct acyclic graph. RESULTS: Of 20,521 patients with OSA on CPAP treatment (29.5% females), 331 (1.6%) had a... (More)
STUDY OBJECTIVES: The aim was to evaluate nasal polyposis as a risk factor for nonadherence to continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA). METHODS: This was a population-based, longitudinal analysis of patients starting CPAP treatment for OSA in the Swedish quality registry Swedevox between 2010 and 2018. Data were cross-linked with national registries. The impact of nasal polyposis on CPAP adherence was analyzed using uni- and multivariable logistic and linear regression models. Relevant confounders (age, sex, usage of nasal and oral steroids) were identified using a direct acyclic graph. RESULTS: Of 20,521 patients with OSA on CPAP treatment (29.5% females), 331 (1.6%) had a diagnosis of nasal polyposis at baseline. At the 1-year follow-up, nasal polyposis was associated with an increased risk of CPAP usage < 4 hours/night (unadjusted odds ratio [OR] 1.21; 95% confidence interval [CI] 0.95-1.55); adjusted OR 1.38; 95% CI 1.08-1.77). In this group, unadjusted nocturnal mean CPAP usage was 15.4 minutes (95% CI -31.62 to 0.83) shorter and was an adjusted 24.1 minutes (95% CI -40.6 to -7.7) shorter compared with patients with OSA without nasal polyposis. CONCLUSIONS: Nasal polyposis is associated with reduced CPAP usage per night. These results highlight the importance of diagnosing nasal polyposis in patients with OSA before the start of CPAP treatment. Treatment of the condition may improve adherence, efficacy, and patient outcomes. CITATION: Bengtsson C, Grote L, Ljunggren M, Ekström M, Palm A. Nasal polyposis is a risk factor for nonadherence to CPAP treatment in sleep apnea: the population-based DISCOVERY study. J Clin Sleep Med. 2023;19(3):573-579.
(Less)
- author
- Bengtsson, Caroline
; Grote, Ludger
; Ljunggren, Mirjam
; Ekström, Magnus
LU
and Palm, Andreas
- organization
- publishing date
- 2023-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adherence, CPAP, nasal obstruction, nasal polyposis, population-based
- in
- Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
- volume
- 19
- issue
- 3
- pages
- 7 pages
- publisher
- American Academy of Sleep Medicine
- external identifiers
-
- scopus:85149181379
- pmid:36546358
- ISSN
- 1550-9389
- DOI
- 10.5664/jcsm.10390
- language
- English
- LU publication?
- yes
- id
- 4f9f9b34-6b7a-47d0-bd35-f88f3705dabd
- date added to LUP
- 2023-03-15 09:54:48
- date last changed
- 2024-06-12 08:39:03
@article{4f9f9b34-6b7a-47d0-bd35-f88f3705dabd,
abstract = {{<p>STUDY OBJECTIVES: The aim was to evaluate nasal polyposis as a risk factor for nonadherence to continuous positive airway pressure (CPAP) treatment in patients with obstructive sleep apnea (OSA). METHODS: This was a population-based, longitudinal analysis of patients starting CPAP treatment for OSA in the Swedish quality registry Swedevox between 2010 and 2018. Data were cross-linked with national registries. The impact of nasal polyposis on CPAP adherence was analyzed using uni- and multivariable logistic and linear regression models. Relevant confounders (age, sex, usage of nasal and oral steroids) were identified using a direct acyclic graph. RESULTS: Of 20,521 patients with OSA on CPAP treatment (29.5% females), 331 (1.6%) had a diagnosis of nasal polyposis at baseline. At the 1-year follow-up, nasal polyposis was associated with an increased risk of CPAP usage < 4 hours/night (unadjusted odds ratio [OR] 1.21; 95% confidence interval [CI] 0.95-1.55); adjusted OR 1.38; 95% CI 1.08-1.77). In this group, unadjusted nocturnal mean CPAP usage was 15.4 minutes (95% CI -31.62 to 0.83) shorter and was an adjusted 24.1 minutes (95% CI -40.6 to -7.7) shorter compared with patients with OSA without nasal polyposis. CONCLUSIONS: Nasal polyposis is associated with reduced CPAP usage per night. These results highlight the importance of diagnosing nasal polyposis in patients with OSA before the start of CPAP treatment. Treatment of the condition may improve adherence, efficacy, and patient outcomes. CITATION: Bengtsson C, Grote L, Ljunggren M, Ekström M, Palm A. Nasal polyposis is a risk factor for nonadherence to CPAP treatment in sleep apnea: the population-based DISCOVERY study. J Clin Sleep Med. 2023;19(3):573-579.</p>}},
author = {{Bengtsson, Caroline and Grote, Ludger and Ljunggren, Mirjam and Ekström, Magnus and Palm, Andreas}},
issn = {{1550-9389}},
keywords = {{adherence; CPAP; nasal obstruction; nasal polyposis; population-based}},
language = {{eng}},
month = {{03}},
number = {{3}},
pages = {{573--579}},
publisher = {{American Academy of Sleep Medicine}},
series = {{Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine}},
title = {{Nasal polyposis is a risk factor for nonadherence to CPAP treatment in sleep apnea : the population-based DISCOVERY study}},
url = {{http://dx.doi.org/10.5664/jcsm.10390}},
doi = {{10.5664/jcsm.10390}},
volume = {{19}},
year = {{2023}},
}