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Blood flow in experimental liver tumors : Effect of vasoactive drugs

Hafstrom, L. ; Persson, B. LU orcid and Sundqvist, K. (1980) In Acta Chirurgica Scandinavica 146(3). p.149-153
Abstract

The effects of infused glucagon, histamine and vasopressin on blood flow in anesthetized rats with intrahepatic tumors were studied using microspheres labelled with 99Tcm or 51Cr isotopes. Considerable circulatory effects were noted both in central hemodynamic parameters as well as in organ and tissue blood flows. Glucagon infusion increased blood flow in the spleen and small intestine while hepatic artery flow was unchanged. Histamine induced a decrease in hepatic and pulmonary blood flow. Vasopressin showed a pronounced decrease in blood flow in all organs measured. Relative tumor blood flow was registered as the ratio between tumor flow and arterial hepatic flow. A relative decrease of tumor blood... (More)

The effects of infused glucagon, histamine and vasopressin on blood flow in anesthetized rats with intrahepatic tumors were studied using microspheres labelled with 99Tcm or 51Cr isotopes. Considerable circulatory effects were noted both in central hemodynamic parameters as well as in organ and tissue blood flows. Glucagon infusion increased blood flow in the spleen and small intestine while hepatic artery flow was unchanged. Histamine induced a decrease in hepatic and pulmonary blood flow. Vasopressin showed a pronounced decrease in blood flow in all organs measured. Relative tumor blood flow was registered as the ratio between tumor flow and arterial hepatic flow. A relative decrease of tumor blood flow in relation to surrounding liver tissue blood flow was registered after infusion of vasopressin. No effects were seen after glucagon or histamine infusion.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
in
Acta Chirurgica Scandinavica
volume
146
issue
3
pages
5 pages
publisher
Almqvist & Wiksell
external identifiers
  • pmid:7468035
  • scopus:0018973950
ISSN
0001-5482
language
English
LU publication?
yes
id
4fbe8ffe-d37e-4a8b-8a13-db7d5b0782a5
date added to LUP
2020-08-15 17:26:54
date last changed
2024-01-02 17:02:19
@article{4fbe8ffe-d37e-4a8b-8a13-db7d5b0782a5,
  abstract     = {{<p>The effects of infused glucagon, histamine and vasopressin on blood flow in anesthetized rats with intrahepatic tumors were studied using microspheres labelled with <sup>99</sup>Tc<sup>m</sup> or <sup>51</sup>Cr isotopes. Considerable circulatory effects were noted both in central hemodynamic parameters as well as in organ and tissue blood flows. Glucagon infusion increased blood flow in the spleen and small intestine while hepatic artery flow was unchanged. Histamine induced a decrease in hepatic and pulmonary blood flow. Vasopressin showed a pronounced decrease in blood flow in all organs measured. Relative tumor blood flow was registered as the ratio between tumor flow and arterial hepatic flow. A relative decrease of tumor blood flow in relation to surrounding liver tissue blood flow was registered after infusion of vasopressin. No effects were seen after glucagon or histamine infusion.</p>}},
  author       = {{Hafstrom, L. and Persson, B. and Sundqvist, K.}},
  issn         = {{0001-5482}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{3}},
  pages        = {{149--153}},
  publisher    = {{Almqvist & Wiksell}},
  series       = {{Acta Chirurgica Scandinavica}},
  title        = {{Blood flow in experimental liver tumors : Effect of vasoactive drugs}},
  volume       = {{146}},
  year         = {{1980}},
}