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Laboratory investigation of myeloproliferative neoplasms (MPNs) : Recommendations of the Canadian MPN group

Busque, Lambert ; Porwit, Anna LU ; Day, Radmila ; Olney, Harold J. ; Leber, Brian ; Éthier, Vincent ; Sirhan, Shireen ; Foltz, Linda ; Prchal, Jaroslav and Kamel-Reid, Suzanne , et al. (2016) In American Journal of Clinical Pathology 146(4). p.408-422
Abstract

Objectives: To standardize diagnostic investigations for myeloproliferative neoplasms (MPNs) to increase homogeneity in patient care and to streamline diagnostic approaches in the most efficient and cost-effective manner. Methods: The development of Canadian expert consensus recommendations for the diagnosis of MPNs began with a review of the following: clinical evidence, daily practice, existing treatment guidelines, and availability of diagnostic tools. Each group member was assigned a specific topic, which they discussed with the entire group during several consensus meetings. Results: This document provides the Canadian MPN group's recommendations, proposed diagnostic algorithms, and background evidence upon which decisions were... (More)

Objectives: To standardize diagnostic investigations for myeloproliferative neoplasms (MPNs) to increase homogeneity in patient care and to streamline diagnostic approaches in the most efficient and cost-effective manner. Methods: The development of Canadian expert consensus recommendations for the diagnosis of MPNs began with a review of the following: clinical evidence, daily practice, existing treatment guidelines, and availability of diagnostic tools. Each group member was assigned a specific topic, which they discussed with the entire group during several consensus meetings. Results: This document provides the Canadian MPN group's recommendations, proposed diagnostic algorithms, and background evidence upon which decisions were made. Conclusions: Standardization of diagnostic investigations will increase homogeneity in patient care and provide a foundation for future clinical research in this rapidly evolving therapeutic area. Streamlining diagnostic approaches in the most efficient and cost-effective manner will also result in significant cost saving for the health care system.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
BCR-ABL negative, CALR, Essential thrombocythemia, JAK2 V617F, MPL, Myelofibrosis, Myeloproliferative neoplasms, Polycythemia vera
in
American Journal of Clinical Pathology
volume
146
issue
4
pages
15 pages
publisher
Oxford University Press
external identifiers
  • pmid:27686169
  • scopus:85014118383
ISSN
0002-9173
DOI
10.1093/ajcp/aqw131
language
English
LU publication?
no
id
4fcae6ad-a4db-4e50-8723-d11ac12c53e4
date added to LUP
2019-05-22 09:38:16
date last changed
2024-04-16 07:13:08
@article{4fcae6ad-a4db-4e50-8723-d11ac12c53e4,
  abstract     = {{<p>Objectives: To standardize diagnostic investigations for myeloproliferative neoplasms (MPNs) to increase homogeneity in patient care and to streamline diagnostic approaches in the most efficient and cost-effective manner. Methods: The development of Canadian expert consensus recommendations for the diagnosis of MPNs began with a review of the following: clinical evidence, daily practice, existing treatment guidelines, and availability of diagnostic tools. Each group member was assigned a specific topic, which they discussed with the entire group during several consensus meetings. Results: This document provides the Canadian MPN group's recommendations, proposed diagnostic algorithms, and background evidence upon which decisions were made. Conclusions: Standardization of diagnostic investigations will increase homogeneity in patient care and provide a foundation for future clinical research in this rapidly evolving therapeutic area. Streamlining diagnostic approaches in the most efficient and cost-effective manner will also result in significant cost saving for the health care system.</p>}},
  author       = {{Busque, Lambert and Porwit, Anna and Day, Radmila and Olney, Harold J. and Leber, Brian and Éthier, Vincent and Sirhan, Shireen and Foltz, Linda and Prchal, Jaroslav and Kamel-Reid, Suzanne and Karsan, Aly and Gupta, Vikas}},
  issn         = {{0002-9173}},
  keywords     = {{BCR-ABL negative; CALR; Essential thrombocythemia; JAK2 V617F; MPL; Myelofibrosis; Myeloproliferative neoplasms; Polycythemia vera}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{4}},
  pages        = {{408--422}},
  publisher    = {{Oxford University Press}},
  series       = {{American Journal of Clinical Pathology}},
  title        = {{Laboratory investigation of myeloproliferative neoplasms (MPNs) : Recommendations of the Canadian MPN group}},
  url          = {{http://dx.doi.org/10.1093/ajcp/aqw131}},
  doi          = {{10.1093/ajcp/aqw131}},
  volume       = {{146}},
  year         = {{2016}},
}