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Validation of urinary antigen test for Streptococcus pneumoniae in patients with pneumococcal pneumonia

Ercis, Serpil ; Ergin, Alper ; Sahin, Gülşen Ozkaya LU ; Hasçelik, Gülşen and Uzun, Omrüm (2006) In Japanese Journal of Infectious Diseases 59(6). p.90-388
Abstract

The study was undertaken to prospectively evaluate a Streptococcus pneumoniae urinary antigen test for diagnosis of pneumococcal pneumonia among patient and control groups between 2004 and 2006. Microbiological analysis for these patients included Gram staining for sputum, sputum and blood culture. Nonconcentrated urine samples were tested using an immunochromatographic assay, the NOW S.pneumoniae antigen test. The urinary antigen test was positive in 9 (15.3%) of 59 patients enrolled in the study and in 8 (73%) of 11 patients with pneumococcal pneumonia confirmed by conventional methods. The test revealed a sensitivity of 72.7% and a specificity of 97.6% with conventional microbiological criteria used as the reference standard. The... (More)

The study was undertaken to prospectively evaluate a Streptococcus pneumoniae urinary antigen test for diagnosis of pneumococcal pneumonia among patient and control groups between 2004 and 2006. Microbiological analysis for these patients included Gram staining for sputum, sputum and blood culture. Nonconcentrated urine samples were tested using an immunochromatographic assay, the NOW S.pneumoniae antigen test. The urinary antigen test was positive in 9 (15.3%) of 59 patients enrolled in the study and in 8 (73%) of 11 patients with pneumococcal pneumonia confirmed by conventional methods. The test revealed a sensitivity of 72.7% and a specificity of 97.6% with conventional microbiological criteria used as the reference standard. The positive predictive value was 88.9% and the negative predictive value was 93%. We concluded that the urinary antigen test can supplement conventional microbiological tests in the diagnosis of pneumococcal pneumonia.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Adolescent, Adult, Aged, Aged, 80 and over, Antigens, Bacterial/urine, Female, Humans, Male, Middle Aged, Pneumonia, Pneumococcal/diagnosis, Predictive Value of Tests, Sensitivity and Specificity, Streptococcus pneumoniae/immunology
in
Japanese Journal of Infectious Diseases
volume
59
issue
6
pages
3 pages
publisher
National Institute of Infectious Diseases. (Tokyo)
external identifiers
  • scopus:33845972978
  • pmid:17186959
ISSN
1344-6304
language
English
LU publication?
no
id
4fe77655-f3c4-4f01-92bd-df6c002106ae
alternative location
http://www0.nih.go.jp/JJID/59/388.html
date added to LUP
2019-06-30 00:58:38
date last changed
2024-01-01 14:29:04
@article{4fe77655-f3c4-4f01-92bd-df6c002106ae,
  abstract     = {{<p>The study was undertaken to prospectively evaluate a Streptococcus pneumoniae urinary antigen test for diagnosis of pneumococcal pneumonia among patient and control groups between 2004 and 2006. Microbiological analysis for these patients included Gram staining for sputum, sputum and blood culture. Nonconcentrated urine samples were tested using an immunochromatographic assay, the NOW S.pneumoniae antigen test. The urinary antigen test was positive in 9 (15.3%) of 59 patients enrolled in the study and in 8 (73%) of 11 patients with pneumococcal pneumonia confirmed by conventional methods. The test revealed a sensitivity of 72.7% and a specificity of 97.6% with conventional microbiological criteria used as the reference standard. The positive predictive value was 88.9% and the negative predictive value was 93%. We concluded that the urinary antigen test can supplement conventional microbiological tests in the diagnosis of pneumococcal pneumonia.</p>}},
  author       = {{Ercis, Serpil and Ergin, Alper and Sahin, Gülşen Ozkaya and Hasçelik, Gülşen and Uzun, Omrüm}},
  issn         = {{1344-6304}},
  keywords     = {{Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Bacterial/urine; Female; Humans; Male; Middle Aged; Pneumonia, Pneumococcal/diagnosis; Predictive Value of Tests; Sensitivity and Specificity; Streptococcus pneumoniae/immunology}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{90--388}},
  publisher    = {{National Institute of Infectious Diseases. (Tokyo)}},
  series       = {{Japanese Journal of Infectious Diseases}},
  title        = {{Validation of urinary antigen test for Streptococcus pneumoniae in patients with pneumococcal pneumonia}},
  url          = {{http://www0.nih.go.jp/JJID/59/388.html}},
  volume       = {{59}},
  year         = {{2006}},
}