DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.
(2015) In Epigenomics 7(4). p.533-537- Abstract
- Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7477911
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Epigenomics
- volume
- 7
- issue
- 4
- pages
- 533 - 537
- publisher
- Future Medicine Ltd.
- external identifiers
-
- pmid:26111027
- wos:000356885200004
- scopus:84933505719
- pmid:26111027
- ISSN
- 1750-192X
- DOI
- 10.2217/epi.15.22
- language
- English
- LU publication?
- yes
- id
- 50121327-ae33-47c5-913f-b2d3e6299938 (old id 7477911)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26111027?dopt=Abstract
- date added to LUP
- 2016-04-01 10:45:06
- date last changed
- 2022-02-17 21:00:38
@article{50121327-ae33-47c5-913f-b2d3e6299938, abstract = {{Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.}}, author = {{Chouliaras, Leonidas and Kenis, Gunter and Visser, Pieter Jelle and Scheltens, Philip and Tsolaki, Magda and Jones, Roy W and Kehoe, Patrick G and Graff, Caroline and Girtler, Nicola G and Wallin, Åsa and Rikkert, Marcel Olde and Spiru, Luiza and Elias-Sonnenschein, Lyzel S and Ramakers, Inez Hgb and Pishva, Ehsan and Os, Jim van and Steinbusch, Harry Wm and Verhey, Frans Rj and van den Hove, Daniel LA and Rutten, Bart Pf}}, issn = {{1750-192X}}, language = {{eng}}, number = {{4}}, pages = {{533--537}}, publisher = {{Future Medicine Ltd.}}, series = {{Epigenomics}}, title = {{DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.}}, url = {{http://dx.doi.org/10.2217/epi.15.22}}, doi = {{10.2217/epi.15.22}}, volume = {{7}}, year = {{2015}}, }