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Simulation of stroke-related damage in cultured human nerve cells

Bicker, Gerd ; Gierse, Andrea ; Tan, Saime and Paquet-Durand, Francois LU (2007) In ALTEX Alternatives To Animal Experimentation 24. p.16-18
Abstract
We describe a novel cell culture protocol for the generation of neurons from a human teratocarcinoma cell line. These neurons were used to investigate hypoxic-ischaemic cell damage and for developing neuroprotective strategies. Cultures of human model neurons should eventually serve to reduce the number of experimental animals in cerebral stroke research.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
reduction, organ-specific, brain-cell cultures, human, neuroprotection, neural differentiation, ischaemia, excitotoxicity, glutamate, replacement, pharmacological testing
in
ALTEX Alternatives To Animal Experimentation
volume
24
pages
16 - 18
publisher
Spektrum Akad Verlag
external identifiers
  • wos:000249535100007
  • scopus:70350731409
ISSN
0946-7785
language
English
LU publication?
yes
id
5026337d-c55c-475f-8ba5-e7f70f97b895 (old id 656822)
date added to LUP
2016-04-01 12:29:38
date last changed
2022-01-27 05:48:46
@article{5026337d-c55c-475f-8ba5-e7f70f97b895,
  abstract     = {{We describe a novel cell culture protocol for the generation of neurons from a human teratocarcinoma cell line. These neurons were used to investigate hypoxic-ischaemic cell damage and for developing neuroprotective strategies. Cultures of human model neurons should eventually serve to reduce the number of experimental animals in cerebral stroke research.}},
  author       = {{Bicker, Gerd and Gierse, Andrea and Tan, Saime and Paquet-Durand, Francois}},
  issn         = {{0946-7785}},
  keywords     = {{reduction; organ-specific; brain-cell cultures; human; neuroprotection; neural differentiation; ischaemia; excitotoxicity; glutamate; replacement; pharmacological testing}},
  language     = {{eng}},
  pages        = {{16--18}},
  publisher    = {{Spektrum Akad Verlag}},
  series       = {{ALTEX Alternatives To Animal Experimentation}},
  title        = {{Simulation of stroke-related damage in cultured human nerve cells}},
  volume       = {{24}},
  year         = {{2007}},
}