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Subcutaneous and intranasal administration of 1-deamino-8-d-arginine vasopressin in the assessment of renal concentration capacity

Tryding, Nils ; Sterner, Gunnar LU ; Berg, Bertel ; Harris, Alan and Lundin, S (1987) In Nephron 45(1). p.27-30
Abstract
Maximum urine concentration capacity was studied in healthy adults using different routes and doses of administration of 1-deamino-8-d-arginine vasopressin (DDAVP) - desmopressin. Plasma levels of DDAVP showed a dose-dependent increase after the subcutaneous but not after the intranasal administration. The effect on urine osmolality was similar but more prolonged after the subcutaneous as compared to the intranasal route. We conclude that subcutaneous injection is a simple and reliable way of administering DDAVP. A dose of 4 μg in adults is optimum diagnostically and it corresponds to 20-40 μg administered intranasally.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nephron
volume
45
issue
1
pages
27 - 30
publisher
Karger
external identifiers
  • scopus:0023226328
ISSN
0028-2766
DOI
10.1159/000184066
language
English
LU publication?
yes
id
5027125a-ba8f-49da-964f-72bc836acdf7
date added to LUP
2019-10-26 17:51:03
date last changed
2021-01-03 04:43:09
@article{5027125a-ba8f-49da-964f-72bc836acdf7,
  abstract     = {{Maximum urine concentration capacity was studied in healthy adults using different routes and doses of administration of 1-deamino-8-d-arginine vasopressin (DDAVP) - desmopressin. Plasma levels of DDAVP showed a dose-dependent increase after the subcutaneous but not after the intranasal administration. The effect on urine osmolality was similar but more prolonged after the subcutaneous as compared to the intranasal route. We conclude that subcutaneous injection is a simple and reliable way of administering DDAVP. A dose of 4 μg in adults is optimum diagnostically and it corresponds to 20-40 μg administered intranasally.}},
  author       = {{Tryding, Nils and Sterner, Gunnar and Berg, Bertel and Harris, Alan and Lundin, S}},
  issn         = {{0028-2766}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{27--30}},
  publisher    = {{Karger}},
  series       = {{Nephron}},
  title        = {{Subcutaneous and intranasal administration of 1-deamino-8-d-arginine vasopressin in the assessment of renal concentration capacity}},
  url          = {{http://dx.doi.org/10.1159/000184066}},
  doi          = {{10.1159/000184066}},
  volume       = {{45}},
  year         = {{1987}},
}