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Joint scientific statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and early vascular ageing.

Jordan, Jens; Nilsson, Peter LU ; Kotsis, Vasilios; Olsen, Michael H; Grassi, Guido; Yumuk, Volkan; Hauner, Hans; Zahorska-Markiewicz, Barbara; Toplak, Hermann and Engeli, Stefan, et al. (2015) In Journal of Hypertension 33(3). p.425-434
Abstract
Current cardiovascular risk scores do not include obesity or fat distribution as independent factors, and may underestimate risk in obese individuals. Assessment of early vascular ageing (EVA) biomarkers including arterial stiffness, central blood pressure, carotid intima-media thickness and flow-mediated vasodilation may help to refine risk assessment in obese individuals in whom traditional cardiovascular risk scores and factors suggest no need for specific medical attention. A number of issues need to be addressed before this approach is ready for translation into routine clinical practice. Methodologies for measurements of vascular markers need to be further standardized and less operator-dependent. The utility of these nontraditional... (More)
Current cardiovascular risk scores do not include obesity or fat distribution as independent factors, and may underestimate risk in obese individuals. Assessment of early vascular ageing (EVA) biomarkers including arterial stiffness, central blood pressure, carotid intima-media thickness and flow-mediated vasodilation may help to refine risk assessment in obese individuals in whom traditional cardiovascular risk scores and factors suggest no need for specific medical attention. A number of issues need to be addressed before this approach is ready for translation into routine clinical practice. Methodologies for measurements of vascular markers need to be further standardized and less operator-dependent. The utility of these nontraditional risk factors will also need to be proven in sufficiently large and properly designed interventional studies. Indeed, published studies on vascular markers in obesity and weight loss vary in quality and study design, are sometimes conducted in small populations, use a variety of differing methodologies and study differing vascular beds. Finally, current vascular measurements are still crude and may not be sufficient to cover the different aspects of EVA in obesity. (Less)
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Contribution to journal
publication status
published
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Journal of Hypertension
volume
33
issue
3
pages
425 - 434
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:25629358
  • wos:000349003300001
  • scopus:84922374734
ISSN
1473-5598
DOI
10.1097/HJH.0000000000000473
language
English
LU publication?
yes
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cd64ef10-9696-418f-a52d-9233fcea8c93 (old id 5039355)
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http://www.ncbi.nlm.nih.gov/pubmed/25629358?dopt=Abstract
date added to LUP
2015-02-04 21:11:46
date last changed
2017-05-28 03:18:33
@article{cd64ef10-9696-418f-a52d-9233fcea8c93,
  abstract     = {Current cardiovascular risk scores do not include obesity or fat distribution as independent factors, and may underestimate risk in obese individuals. Assessment of early vascular ageing (EVA) biomarkers including arterial stiffness, central blood pressure, carotid intima-media thickness and flow-mediated vasodilation may help to refine risk assessment in obese individuals in whom traditional cardiovascular risk scores and factors suggest no need for specific medical attention. A number of issues need to be addressed before this approach is ready for translation into routine clinical practice. Methodologies for measurements of vascular markers need to be further standardized and less operator-dependent. The utility of these nontraditional risk factors will also need to be proven in sufficiently large and properly designed interventional studies. Indeed, published studies on vascular markers in obesity and weight loss vary in quality and study design, are sometimes conducted in small populations, use a variety of differing methodologies and study differing vascular beds. Finally, current vascular measurements are still crude and may not be sufficient to cover the different aspects of EVA in obesity.},
  author       = {Jordan, Jens and Nilsson, Peter and Kotsis, Vasilios and Olsen, Michael H and Grassi, Guido and Yumuk, Volkan and Hauner, Hans and Zahorska-Markiewicz, Barbara and Toplak, Hermann and Engeli, Stefan and Finer, Nick},
  issn         = {1473-5598},
  language     = {eng},
  number       = {3},
  pages        = {425--434},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Joint scientific statement of the European Association for the Study of Obesity and the European Society of Hypertension: obesity and early vascular ageing.},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000000473},
  volume       = {33},
  year         = {2015},
}