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Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged

Eikendal, Anouk L M; Groenewegen, Karlijn A; Anderson, Todd J; Britton, Annie R; Engström, Gunnar LU ; Evans, Greg W; de Graaf, Jacqueline; Grobbee, Diederick E; Hedblad, Bo LU and Holewijn, Suzanne, et al. (2015) In Hypertension 65(4). p.707-707
Abstract
Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was... (More)
Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was obtained. We assessed the relationship between risk factors and CIMT and the relationship between CIMT and first-time myocardial infarction or stroke using a multivariable linear mixed-effects model and a Cox proportional-hazards model, respectively. During a follow-up of 16.3 years, 55 first-time myocardial infarctions or strokes occurred. Median CIMT was 0.63 mm. Of the risk factors under study, age, sex, diastolic blood pressure, body mass index, total cholesterol, and high-density lipoprotein cholesterol related to CIMT. Furthermore, CIMT related to first-time myocardial infarction or stroke with a hazard ratio of 1.40 per SD increase in CIMT, independent of risk factors (95% confidence interval, 1.11-1.76). CIMT may be a valuable marker for cardiovascular risk in adults aged <45 years who are not yet eligible for standard cardiovascular risk screening. This is especially relevant in those with an increased, unfavor-able risk factor burden. (Less)
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Contribution to journal
publication status
published
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Hypertension
volume
65
issue
4
pages
707 - 707
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:25624341
  • wos:000350971600003
  • scopus:84929132225
ISSN
1524-4563
DOI
10.1161/HYPERTENSIONAHA.114.04658
language
English
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yes
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0face793-571e-48df-989a-fb4a12491af2 (old id 5039563)
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http://www.ncbi.nlm.nih.gov/pubmed/25624341?dopt=Abstract
date added to LUP
2015-02-04 18:06:50
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2017-11-05 03:01:08
@article{0face793-571e-48df-989a-fb4a12491af2,
  abstract     = {Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged &lt;45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged &lt;45 years. Our study population consisted of 3067 adults aged &lt;45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population-based cohort studies evaluating CIMT measurements. Information on risk factors, CIMT measurements, and follow-up of the combined end point (first-time myocardial infarction or stroke) was obtained. We assessed the relationship between risk factors and CIMT and the relationship between CIMT and first-time myocardial infarction or stroke using a multivariable linear mixed-effects model and a Cox proportional-hazards model, respectively. During a follow-up of 16.3 years, 55 first-time myocardial infarctions or strokes occurred. Median CIMT was 0.63 mm. Of the risk factors under study, age, sex, diastolic blood pressure, body mass index, total cholesterol, and high-density lipoprotein cholesterol related to CIMT. Furthermore, CIMT related to first-time myocardial infarction or stroke with a hazard ratio of 1.40 per SD increase in CIMT, independent of risk factors (95% confidence interval, 1.11-1.76). CIMT may be a valuable marker for cardiovascular risk in adults aged &lt;45 years who are not yet eligible for standard cardiovascular risk screening. This is especially relevant in those with an increased, unfavor-able risk factor burden.},
  author       = {Eikendal, Anouk L M and Groenewegen, Karlijn A and Anderson, Todd J and Britton, Annie R and Engström, Gunnar and Evans, Greg W and de Graaf, Jacqueline and Grobbee, Diederick E and Hedblad, Bo and Holewijn, Suzanne and Ikeda, Ai and Kitagawa, Kazuo and Kitamura, Akihiko and Lonn, Eva M and Lorenz, Matthias W and Mathiesen, Ellisiv B and Nijpels, Giel and Dekker, Jacqueline M and Okazaki, Shuhei and O'Leary, Daniel H and Polak, Joseph F and Price, Jacqueline F and Robertson, Christine and Rembold, Christopher M and Rosvall, Maria and Rundek, Tatjana and Salonen, Jukka T and Sitzer, Matthias and Stehouwer, Coen D A and Hoefer, Imo E and Peters, Sanne A E and Bots, Michiel L and den Ruijter, Hester M},
  issn         = {1524-4563},
  language     = {eng},
  number       = {4},
  pages        = {707--707},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Hypertension},
  title        = {Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged},
  url          = {http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04658},
  volume       = {65},
  year         = {2015},
}