Hepatitis C virus attributable liver cancer in the country of Georgia, 2015–2019 : a case–control study
(2024) In BMC Infectious Diseases 24(1).- Abstract
Background: Hepatitis C virus (HCV) infection can lead to a type of primary liver cancer called hepatocellular carcinoma (HCC). Georgia, a high HCV prevalence country, started an HCV elimination program in 2015. In addition to tracking incidence and mortality, surveillance for the HCV-attributable fraction of HCC is an important indicator of the program’s impact. This study assesses HCV infection-attributable HCC in the Georgian population. Methods: This case–control study utilized HCV programmatic and Georgian Cancer Registry data from 2015–2019. Bivariate logistic regression and age- and sex-stratified analyses assessed HCV and liver cancer association. HCV-attributable liver cancer proportions for the HCV-exposed and total population... (More)
Background: Hepatitis C virus (HCV) infection can lead to a type of primary liver cancer called hepatocellular carcinoma (HCC). Georgia, a high HCV prevalence country, started an HCV elimination program in 2015. In addition to tracking incidence and mortality, surveillance for the HCV-attributable fraction of HCC is an important indicator of the program’s impact. This study assesses HCV infection-attributable HCC in the Georgian population. Methods: This case–control study utilized HCV programmatic and Georgian Cancer Registry data from 2015–2019. Bivariate logistic regression and age- and sex-stratified analyses assessed HCV and liver cancer association. HCV-attributable liver cancer proportions for the HCV-exposed and total population were calculated. A sub-analysis was performed for HCC cases specifically. Results: The total study population was 3874 with 496 liver cancer cases and 3378 controls. The odds for HCV-infected individuals developing liver cancer was 20.1 (95% confidence interval [CI] 15.97–25.37), and the odds of developing HCC was 16.84 (95% CI 12.01–23.83) compared to the HCV-negative group. Odds ratios varied across strata, with HCV-infected older individuals and women having higher odds of developing both liver cancer and HCC. A large proportion of liver cancer and HCC can be attributed to HCV in HCV-infected individuals; however, in the general population, the burden of liver cancer and HCC cannot be explained by HCV alone. Conclusion: HCV was significantly associated with a higher risk of developing liver cancer and HCC in the Georgian population. In addition, given Georgia’s high HCV burden, increased HCC monitoring in HCV-infected patients is needed.
(Less)
- author
- Surguladze, Sophia ; Armstrong, Paige A. ; Beckett, Geoff A. ; Shadaker, Shaun ; Gamkrelidze, Amiran ; Tsereteli, Maia ; Getia, Vladimer and Asamoah, Benedict Oppong LU
- organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Georgia, Hepatitis C, Hepatocellular carcinoma, Liver cancer, Viral hepatitis
- in
- BMC Infectious Diseases
- volume
- 24
- issue
- 1
- article number
- 1045
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85205336014
- pmid:39333949
- ISSN
- 1471-2334
- DOI
- 10.1186/s12879-024-09916-7
- language
- English
- LU publication?
- yes
- id
- 503e9822-f027-438f-ac98-cad147fbeefc
- date added to LUP
- 2024-11-27 13:31:16
- date last changed
- 2024-12-11 15:12:26
@article{503e9822-f027-438f-ac98-cad147fbeefc,
abstract = {{<p>Background: Hepatitis C virus (HCV) infection can lead to a type of primary liver cancer called hepatocellular carcinoma (HCC). Georgia, a high HCV prevalence country, started an HCV elimination program in 2015. In addition to tracking incidence and mortality, surveillance for the HCV-attributable fraction of HCC is an important indicator of the program’s impact. This study assesses HCV infection-attributable HCC in the Georgian population. Methods: This case–control study utilized HCV programmatic and Georgian Cancer Registry data from 2015–2019. Bivariate logistic regression and age- and sex-stratified analyses assessed HCV and liver cancer association. HCV-attributable liver cancer proportions for the HCV-exposed and total population were calculated. A sub-analysis was performed for HCC cases specifically. Results: The total study population was 3874 with 496 liver cancer cases and 3378 controls. The odds for HCV-infected individuals developing liver cancer was 20.1 (95% confidence interval [CI] 15.97–25.37), and the odds of developing HCC was 16.84 (95% CI 12.01–23.83) compared to the HCV-negative group. Odds ratios varied across strata, with HCV-infected older individuals and women having higher odds of developing both liver cancer and HCC. A large proportion of liver cancer and HCC can be attributed to HCV in HCV-infected individuals; however, in the general population, the burden of liver cancer and HCC cannot be explained by HCV alone. Conclusion: HCV was significantly associated with a higher risk of developing liver cancer and HCC in the Georgian population. In addition, given Georgia’s high HCV burden, increased HCC monitoring in HCV-infected patients is needed.</p>}},
author = {{Surguladze, Sophia and Armstrong, Paige A. and Beckett, Geoff A. and Shadaker, Shaun and Gamkrelidze, Amiran and Tsereteli, Maia and Getia, Vladimer and Asamoah, Benedict Oppong}},
issn = {{1471-2334}},
keywords = {{Georgia; Hepatitis C; Hepatocellular carcinoma; Liver cancer; Viral hepatitis}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Infectious Diseases}},
title = {{Hepatitis C virus attributable liver cancer in the country of Georgia, 2015–2019 : a case–control study}},
url = {{http://dx.doi.org/10.1186/s12879-024-09916-7}},
doi = {{10.1186/s12879-024-09916-7}},
volume = {{24}},
year = {{2024}},
}