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A fast semi-quantitative LC-MS method for measurement of intact apolipoprotein A-I reveals novel proteoforms in serum.

Gåfvels, Mats LU and Bengtson, Per LU (2015) In Clinica Chimica Acta 442(Jan 17). p.87-95
Abstract
Surrogate markers for reverse cholesterol transport (RCT) efficiency such as HDL cholesterol and immune methods for apolipoprotein A-I (ApoA-I) may not fully reflect the actual efficiency of the RCT pathway. Several genetic variants and different posttranslational proteoforms of ApoA-I may unevenly affect the functionality of the HDL particle to efflux cholesterol. A method employing top-down immunoaffinity LC-MS of ApoA-I in order to characterize the most prevalent ApoA-I proteoforms in human plasma is described.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinica Chimica Acta
volume
442
issue
Jan 17
pages
87 - 95
publisher
Elsevier
external identifiers
  • pmid:25603406
  • wos:000352045900018
  • scopus:84961289750
ISSN
0009-8981
DOI
10.1016/j.cca.2015.01.011
language
English
LU publication?
yes
id
c86b8158-ba8d-4237-a187-1a2eefea5939 (old id 5040127)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25603406?dopt=Abstract
date added to LUP
2015-02-03 19:47:45
date last changed
2017-10-22 03:29:29
@article{c86b8158-ba8d-4237-a187-1a2eefea5939,
  abstract     = {Surrogate markers for reverse cholesterol transport (RCT) efficiency such as HDL cholesterol and immune methods for apolipoprotein A-I (ApoA-I) may not fully reflect the actual efficiency of the RCT pathway. Several genetic variants and different posttranslational proteoforms of ApoA-I may unevenly affect the functionality of the HDL particle to efflux cholesterol. A method employing top-down immunoaffinity LC-MS of ApoA-I in order to characterize the most prevalent ApoA-I proteoforms in human plasma is described.},
  author       = {Gåfvels, Mats and Bengtson, Per},
  issn         = {0009-8981},
  language     = {eng},
  number       = {Jan 17},
  pages        = {87--95},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {A fast semi-quantitative LC-MS method for measurement of intact apolipoprotein A-I reveals novel proteoforms in serum.},
  url          = {http://dx.doi.org/10.1016/j.cca.2015.01.011},
  volume       = {442},
  year         = {2015},
}