Thromboinflammatory challenges in stroke pathophysiology
(2023) In Seminars in Immunopathology 45(3). p.389-410- Abstract
Despite years of encouraging translational research, ischemic stroke still remains as one of the highest unmet medical needs nowadays, causing a tremendous burden to health care systems worldwide. Following an ischemic insult, a complex signaling pathway emerges leading to highly interconnected thrombotic as well as neuroinflammatory signatures, the so-called thromboinflammatory cascade. Here, we thoroughly review the cell-specific and time-dependent role of different immune cell types, i.e., neutrophils, macrophages, T and B cells, as key thromboinflammatory mediators modulating the neuroinflammatory response upon stroke. Similarly, the relevance of platelets and their tight crosstalk with a variety of immune cells highlights the... (More)
Despite years of encouraging translational research, ischemic stroke still remains as one of the highest unmet medical needs nowadays, causing a tremendous burden to health care systems worldwide. Following an ischemic insult, a complex signaling pathway emerges leading to highly interconnected thrombotic as well as neuroinflammatory signatures, the so-called thromboinflammatory cascade. Here, we thoroughly review the cell-specific and time-dependent role of different immune cell types, i.e., neutrophils, macrophages, T and B cells, as key thromboinflammatory mediators modulating the neuroinflammatory response upon stroke. Similarly, the relevance of platelets and their tight crosstalk with a variety of immune cells highlights the relevance of this cell-cell interaction during microvascular dysfunction, neovascularization, and cellular adhesion. Ultimately, we provide an up-to-date overview of therapeutic approaches mechanistically targeting thromboinflammation currently under clinical translation, especially focusing on phase I to III clinical trials.
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- author
- Szepanowski, R D ; Haupeltshofer, S LU ; Vonhof, S E ; Frank, B ; Kleinschnitz, C and Casas, A I
- publishing date
- 2023-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Inflammation, Thrombosis/etiology, Stroke/therapy, Blood Platelets, Signal Transduction
- in
- Seminars in Immunopathology
- volume
- 45
- issue
- 3
- pages
- 389 - 410
- publisher
- Springer
- external identifiers
-
- scopus:85160856040
- pmid:37273022
- ISSN
- 1863-2300
- DOI
- 10.1007/s00281-023-00994-4
- language
- English
- LU publication?
- no
- additional info
- © 2023. The Author(s).
- id
- 50470d9b-428f-4c4c-93a3-3d4ebe6e7e15
- date added to LUP
- 2026-01-20 10:40:04
- date last changed
- 2026-01-21 04:02:06
@article{50470d9b-428f-4c4c-93a3-3d4ebe6e7e15,
abstract = {{<p>Despite years of encouraging translational research, ischemic stroke still remains as one of the highest unmet medical needs nowadays, causing a tremendous burden to health care systems worldwide. Following an ischemic insult, a complex signaling pathway emerges leading to highly interconnected thrombotic as well as neuroinflammatory signatures, the so-called thromboinflammatory cascade. Here, we thoroughly review the cell-specific and time-dependent role of different immune cell types, i.e., neutrophils, macrophages, T and B cells, as key thromboinflammatory mediators modulating the neuroinflammatory response upon stroke. Similarly, the relevance of platelets and their tight crosstalk with a variety of immune cells highlights the relevance of this cell-cell interaction during microvascular dysfunction, neovascularization, and cellular adhesion. Ultimately, we provide an up-to-date overview of therapeutic approaches mechanistically targeting thromboinflammation currently under clinical translation, especially focusing on phase I to III clinical trials.</p>}},
author = {{Szepanowski, R D and Haupeltshofer, S and Vonhof, S E and Frank, B and Kleinschnitz, C and Casas, A I}},
issn = {{1863-2300}},
keywords = {{Humans; Inflammation; Thrombosis/etiology; Stroke/therapy; Blood Platelets; Signal Transduction}},
language = {{eng}},
number = {{3}},
pages = {{389--410}},
publisher = {{Springer}},
series = {{Seminars in Immunopathology}},
title = {{Thromboinflammatory challenges in stroke pathophysiology}},
url = {{http://dx.doi.org/10.1007/s00281-023-00994-4}},
doi = {{10.1007/s00281-023-00994-4}},
volume = {{45}},
year = {{2023}},
}