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Risk Factors for Penile Intraepithelial Neoplasia : A Population-based Register Study in Sweden, 2000-2012

Kristiansen, Sinja LU ; Svensson, Åke LU ; Drevin, Linda ; Forslund, Ola LU ; Torbrand, Christian LU and Bjartling, Carina LU (2019) In Acta Dermato-Venereologica 99(3). p.315-320
Abstract

Studies on risk factors for penile intraepithelial neo-plasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14.7, 95% CI 6.5-33.4) including lichen planus (12.0, 95% CI 3.0-48.0), indicating lichen planus to be an important risk factor. Increased ORs were also observed for diseases of the prepuce (4.0, 95% CI 2.2-7.4), immunosuppressive... (More)

Studies on risk factors for penile intraepithelial neo-plasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14.7, 95% CI 6.5-33.4) including lichen planus (12.0, 95% CI 3.0-48.0), indicating lichen planus to be an important risk factor. Increased ORs were also observed for diseases of the prepuce (4.0, 95% CI 2.2-7.4), immunosuppressive drugs (5.0, 95% CI 2.5-9.8), penile surgical procedures (4.8, 95% CI 2.2-10.8), balanitis (9.2, 95% CI 5.0-16.8), genital warts (9.9, 95% CI 4.3-22.7) and organ transplantation (7.0, 95% CI 2.4-20.8). This study demonstrates important risk factors for penile intraepithelial neoplasia, providing knowledge that can help prevent the development of penile cancer.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CIS, lichen planus, penile cancer, penile cancer in situ, penile intraepithelial neoplasia, risk factors, PeIN
in
Acta Dermato-Venereologica
volume
99
issue
3
pages
6 pages
publisher
Medical Journals Limited
external identifiers
  • pmid:30426132
  • scopus:85062427182
ISSN
1651-2057
DOI
10.2340/00015555-3083
language
English
LU publication?
yes
id
504e3db7-44b1-4167-ba17-a9c93a30b1b1
date added to LUP
2019-03-12 14:12:00
date last changed
2024-05-14 03:34:43
@article{504e3db7-44b1-4167-ba17-a9c93a30b1b1,
  abstract     = {{<p>Studies on risk factors for penile intraepithelial neo-plasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14.7, 95% CI 6.5-33.4) including lichen planus (12.0, 95% CI 3.0-48.0), indicating lichen planus to be an important risk factor. Increased ORs were also observed for diseases of the prepuce (4.0, 95% CI 2.2-7.4), immunosuppressive drugs (5.0, 95% CI 2.5-9.8), penile surgical procedures (4.8, 95% CI 2.2-10.8), balanitis (9.2, 95% CI 5.0-16.8), genital warts (9.9, 95% CI 4.3-22.7) and organ transplantation (7.0, 95% CI 2.4-20.8). This study demonstrates important risk factors for penile intraepithelial neoplasia, providing knowledge that can help prevent the development of penile cancer.</p>}},
  author       = {{Kristiansen, Sinja and Svensson, Åke and Drevin, Linda and Forslund, Ola and Torbrand, Christian and Bjartling, Carina}},
  issn         = {{1651-2057}},
  keywords     = {{CIS; lichen planus; penile cancer; penile cancer in situ; penile intraepithelial neoplasia; risk factors; PeIN}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{315--320}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{Risk Factors for Penile Intraepithelial Neoplasia : A Population-based Register Study in Sweden, 2000-2012}},
  url          = {{http://dx.doi.org/10.2340/00015555-3083}},
  doi          = {{10.2340/00015555-3083}},
  volume       = {{99}},
  year         = {{2019}},
}