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Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia

Yu, Yang; Luo, Guang-hua; Zhang, Jun; Jiang, Hua; Wei, Jiang; Shi, Yuan-ping; Zhang, Xiao-ying and Xu, Ning LU (2015) In Archives of Gynecology and Obstetrics 291(2). p.299-303
Abstract
The present study examined mRNA levels of apolipoprotein M (apoM) and apolipoprotein AI (apoAI) in the term placental tissues obtained from 37 women with normal birth weight neonates and from 37 women with macrosomic neonates (birth body weight a parts per thousand yen4,000 g), and further discussed possible clinical significance of these observations. The mRNA levels of apoM and apoAI in the placental tissues were determined by the real time RT-PCR, which demonstrated that both apoM and apoAI mRNA levels were significantly higher in the placentas from macrosomia than those from normal birth. Moreover, we analyzed the overexpressions of apoM and apoAI with the clinical data. Meanwhile we examined several known risk factors of macrosomia... (More)
The present study examined mRNA levels of apolipoprotein M (apoM) and apolipoprotein AI (apoAI) in the term placental tissues obtained from 37 women with normal birth weight neonates and from 37 women with macrosomic neonates (birth body weight a parts per thousand yen4,000 g), and further discussed possible clinical significance of these observations. The mRNA levels of apoM and apoAI in the placental tissues were determined by the real time RT-PCR, which demonstrated that both apoM and apoAI mRNA levels were significantly higher in the placentas from macrosomia than those from normal birth. Moreover, we analyzed the overexpressions of apoM and apoAI with the clinical data. Meanwhile we examined several known risk factors of macrosomia including the mRNA levels of insulin-like growth factor I (IGF-I), IGF-II, insulin-like growth factor I receptor (IGF-IR) and IGF-IIR. It demonstrated that apoM expression was significantly positively correlated to the placental weight, fetal birth weight, pregestational body mass index (BMI), weight gain during pregnancy, maternal weight, maternal BMI and the mRNA levels of IGF-IR as well as IGF-IIR. The apoAI mRNA level was statistically significantly correlated to the placental weight, fetal birth weight, IGF-I and IGF-IR mRNA levels. Binary logistic regression analysis suggested that both apoM and apoAI mRNA may considered as independent risk factors for macrosomia. The clinical significance needs further investigation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Macrosomia, Placenta, ApoM, ApoAI, PCR
in
Archives of Gynecology and Obstetrics
volume
291
issue
2
pages
299 - 303
publisher
Springer
external identifiers
  • wos:000348145800013
  • scopus:84925252388
ISSN
1432-0711
DOI
10.1007/s00404-014-3441-z
language
English
LU publication?
yes
id
ae29c032-4f19-401c-99c6-92c0a9204c7d (old id 5053317)
date added to LUP
2015-03-02 07:14:30
date last changed
2017-01-01 03:27:33
@article{ae29c032-4f19-401c-99c6-92c0a9204c7d,
  abstract     = {The present study examined mRNA levels of apolipoprotein M (apoM) and apolipoprotein AI (apoAI) in the term placental tissues obtained from 37 women with normal birth weight neonates and from 37 women with macrosomic neonates (birth body weight a parts per thousand yen4,000 g), and further discussed possible clinical significance of these observations. The mRNA levels of apoM and apoAI in the placental tissues were determined by the real time RT-PCR, which demonstrated that both apoM and apoAI mRNA levels were significantly higher in the placentas from macrosomia than those from normal birth. Moreover, we analyzed the overexpressions of apoM and apoAI with the clinical data. Meanwhile we examined several known risk factors of macrosomia including the mRNA levels of insulin-like growth factor I (IGF-I), IGF-II, insulin-like growth factor I receptor (IGF-IR) and IGF-IIR. It demonstrated that apoM expression was significantly positively correlated to the placental weight, fetal birth weight, pregestational body mass index (BMI), weight gain during pregnancy, maternal weight, maternal BMI and the mRNA levels of IGF-IR as well as IGF-IIR. The apoAI mRNA level was statistically significantly correlated to the placental weight, fetal birth weight, IGF-I and IGF-IR mRNA levels. Binary logistic regression analysis suggested that both apoM and apoAI mRNA may considered as independent risk factors for macrosomia. The clinical significance needs further investigation.},
  author       = {Yu, Yang and Luo, Guang-hua and Zhang, Jun and Jiang, Hua and Wei, Jiang and Shi, Yuan-ping and Zhang, Xiao-ying and Xu, Ning},
  issn         = {1432-0711},
  keyword      = {Macrosomia,Placenta,ApoM,ApoAI,PCR},
  language     = {eng},
  number       = {2},
  pages        = {299--303},
  publisher    = {Springer},
  series       = {Archives of Gynecology and Obstetrics},
  title        = {Increased mRNA levels of apolipoprotein M and apolipoprotein AI in the placental tissues with fetal macrosomia},
  url          = {http://dx.doi.org/10.1007/s00404-014-3441-z},
  volume       = {291},
  year         = {2015},
}