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Interaction effect of sex and onset of Alzheimer’s disease—rates of progression and prognosis.

Wattmo, Carina LU (2022) 16th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD 2022)
Abstract
Objectives: To investigate the interaction effect of sex and early vs. late onset of Alzheimer’s disease (AD) on long-term cognitive and functional outcomes and survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study of clinical practice involving 1,017 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibitor treatment. The patients were evaluated using cognitive and functional assessment scales at baseline and semi-annually over 3 years. The date of death was recorded for 20 years. Results: Women with late-onset AD (LOAD) showed a higher frequency of apolipoprotein E (APOE) ε4-carriers than did men with LOAD (71% vs. 58%, p<0.001). This sex... (More)
Objectives: To investigate the interaction effect of sex and early vs. late onset of Alzheimer’s disease (AD) on long-term cognitive and functional outcomes and survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study of clinical practice involving 1,017 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibitor treatment. The patients were evaluated using cognitive and functional assessment scales at baseline and semi-annually over 3 years. The date of death was recorded for 20 years. Results: Women with late-onset AD (LOAD) showed a higher frequency of apolipoprotein E (APOE) ε4-carriers than did men with LOAD (71% vs. 58%, p<0.001). This sex difference was not detected in early-onset AD (EOAD). The annual decline in Alzheimer’s Disease Assessment Scale–cognitive subscale was faster in women with EOAD compared with women with LOAD (mean, 95% confidence interval) (5.8, 3.9–7.8 vs. 3.0, 2.3–3.7 points; p=0.013), but this difference was not observed in men. Functional deterioration rates did not differ between the groups. The survival time after AD diagnosis was longer in women with LOAD than in men with LOAD (7.0, 6.7–7.3 vs. 5.4, 5.1–5.8 years; p<0.001), but this sex difference was not found in EOAD. Conclusions: Women, but not men, with EOAD demonstrated almost twice as fast long-term cognitive decline compared with the LOAD groups. Women with LOAD had a lower education, exhibited a high proportion of APOE ε4-carriers and approximately 50% lived alone. Men with LOAD had a shorter lifespan after diagnosis than did all other patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to conference
publication status
published
subject
keywords
Alzheimer's disease, Sex, Age at onset
conference name
16th International Conference on Alzheimer's and Parkinson's Diseases (AD/PD 2022)
conference location
Barcelona, Spain
conference dates
2022-03-16 - 2022-03-20
language
English
LU publication?
yes
id
50558fd6-1387-425d-b6cf-e94d2c879e89
alternative location
https://cslide.ctimeetingtech.com/adpd22/attendee/person/80
date added to LUP
2022-03-31 12:25:21
date last changed
2022-03-31 14:47:13
@misc{50558fd6-1387-425d-b6cf-e94d2c879e89,
  abstract     = {{Objectives: To investigate the interaction effect of sex and early vs. late onset of Alzheimer’s disease (AD) on long-term cognitive and functional outcomes and survival. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, observational, multicentre study of clinical practice involving 1,017 participants diagnosed with mild-to-moderate AD at the start of cholinesterase inhibitor treatment. The patients were evaluated using cognitive and functional assessment scales at baseline and semi-annually over 3 years. The date of death was recorded for 20 years. Results: Women with late-onset AD (LOAD) showed a higher frequency of apolipoprotein E (APOE) ε4-carriers than did men with LOAD (71% vs. 58%, p&lt;0.001). This sex difference was not detected in early-onset AD (EOAD). The annual decline in Alzheimer’s Disease Assessment Scale–cognitive subscale was faster in women with EOAD compared with women with LOAD (mean, 95% confidence interval) (5.8, 3.9–7.8 vs. 3.0, 2.3–3.7 points; p=0.013), but this difference was not observed in men. Functional deterioration rates did not differ between the groups. The survival time after AD diagnosis was longer in women with LOAD than in men with LOAD (7.0, 6.7–7.3 vs. 5.4, 5.1–5.8 years; p&lt;0.001), but this sex difference was not found in EOAD. Conclusions: Women, but not men, with EOAD demonstrated almost twice as fast long-term cognitive decline compared with the LOAD groups. Women with LOAD had a lower education, exhibited a high proportion of APOE ε4-carriers and approximately 50% lived alone. Men with LOAD had a shorter lifespan after diagnosis than did all other patients.}},
  author       = {{Wattmo, Carina}},
  keywords     = {{Alzheimer's disease; Sex; Age at onset}},
  language     = {{eng}},
  title        = {{Interaction effect of sex and onset of Alzheimer’s disease—rates of progression and prognosis.}},
  url          = {{https://cslide.ctimeetingtech.com/adpd22/attendee/person/80}},
  year         = {{2022}},
}