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Clinical Significance of LINC00261 in the Pathogenesis of Pancreatic, Colorectal, Hepatocellular, and Gallbladder Cancer

Bana, Sanjana ; Daffara, Sia ; Dagar, Aastha ; Tiwari, Ashutosh Kumar ; Medhi, Kanupriya ; Mukherjee, Sagarika ; Uttam, Vivek ; Ansari, Md Rizwan ; Tuli, Hardeep Singh and Yadav, Vikas LU orcid , et al. (2025) In Diseases 13(3).
Abstract

Pancreatic (PC), colorectal (CRC), hepatocellular (HCC), and gallbladder (GC) cancers together account for nearly 20% of all cancer cases. However, specific biomarkers and therapeutic targets for these cancers are lacking. Diagnosing these cancers early and providing timely, appropriate treatment to improve patient outcomes is crucial. In this context, previous studies, including ours, have highlighted the potential of non-coding RNAs, particularly long non-coding RNAs (lncRNAs), in diagnosing and prognosis of various cancers. This review focuses on the mechanistic role of the recently identified lncRNA LINC00261 in PC, CRC, HCC, and GC. Our comprehensive literature analysis revealed that LINC00261 functions as a tumor suppressor, and... (More)

Pancreatic (PC), colorectal (CRC), hepatocellular (HCC), and gallbladder (GC) cancers together account for nearly 20% of all cancer cases. However, specific biomarkers and therapeutic targets for these cancers are lacking. Diagnosing these cancers early and providing timely, appropriate treatment to improve patient outcomes is crucial. In this context, previous studies, including ours, have highlighted the potential of non-coding RNAs, particularly long non-coding RNAs (lncRNAs), in diagnosing and prognosis of various cancers. This review focuses on the mechanistic role of the recently identified lncRNA LINC00261 in PC, CRC, HCC, and GC. Our comprehensive literature analysis revealed that LINC00261 functions as a tumor suppressor, and its reduced expression is associated with larger tumor size, advanced tumor-node-metastasis (TNM) stages, lymphatic metastasis, and poorer overall survival rates. Additionally, we discovered that LINC00261 acts as a molecular sponge for miRNAs, such as miR-550a-3p, miR-23a-3p, miR-148a, miR-324-3p, and miR-105-5p, regulating critical cancer-related signaling pathways, including PI3K/Akt/mTOR, Protein kinase B, and Mammalian target of rapamycin (mTOR). Further bioinformatic analysis revealed that LINC00261 regulates key cellular processes, such as protein-DNA complex formation, ribonuclease complex activity, histone deacetylase complexes, and nuclear matrix interactions. Overall, we believe that LINC00261 holds significant promise as a future biomarker and, when combined with existing treatment strategies, may enhance cancer patient care and survival.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
colorectal cancer, gall bladder cancer, hepatocellular carcinoma, LINC00261, lncRNA, pancreatic cancer
in
Diseases
volume
13
issue
3
article number
89
publisher
MDPI AG
external identifiers
  • scopus:105001121355
  • pmid:40136629
ISSN
2079-9721
DOI
10.3390/diseases13030089
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 by the authors.
id
505df6d2-2595-4300-92cf-495e12cd9948
date added to LUP
2025-12-05 14:16:30
date last changed
2025-12-06 03:33:12
@article{505df6d2-2595-4300-92cf-495e12cd9948,
  abstract     = {{<p>Pancreatic (PC), colorectal (CRC), hepatocellular (HCC), and gallbladder (GC) cancers together account for nearly 20% of all cancer cases. However, specific biomarkers and therapeutic targets for these cancers are lacking. Diagnosing these cancers early and providing timely, appropriate treatment to improve patient outcomes is crucial. In this context, previous studies, including ours, have highlighted the potential of non-coding RNAs, particularly long non-coding RNAs (lncRNAs), in diagnosing and prognosis of various cancers. This review focuses on the mechanistic role of the recently identified lncRNA LINC00261 in PC, CRC, HCC, and GC. Our comprehensive literature analysis revealed that LINC00261 functions as a tumor suppressor, and its reduced expression is associated with larger tumor size, advanced tumor-node-metastasis (TNM) stages, lymphatic metastasis, and poorer overall survival rates. Additionally, we discovered that LINC00261 acts as a molecular sponge for miRNAs, such as miR-550a-3p, miR-23a-3p, miR-148a, miR-324-3p, and miR-105-5p, regulating critical cancer-related signaling pathways, including PI3K/Akt/mTOR, Protein kinase B, and Mammalian target of rapamycin (mTOR). Further bioinformatic analysis revealed that LINC00261 regulates key cellular processes, such as protein-DNA complex formation, ribonuclease complex activity, histone deacetylase complexes, and nuclear matrix interactions. Overall, we believe that LINC00261 holds significant promise as a future biomarker and, when combined with existing treatment strategies, may enhance cancer patient care and survival.</p>}},
  author       = {{Bana, Sanjana and Daffara, Sia and Dagar, Aastha and Tiwari, Ashutosh Kumar and Medhi, Kanupriya and Mukherjee, Sagarika and Uttam, Vivek and Ansari, Md Rizwan and Tuli, Hardeep Singh and Yadav, Vikas and Jain, Aklank}},
  issn         = {{2079-9721}},
  keywords     = {{colorectal cancer; gall bladder cancer; hepatocellular carcinoma; LINC00261; lncRNA; pancreatic cancer}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{MDPI AG}},
  series       = {{Diseases}},
  title        = {{Clinical Significance of LINC00261 in the Pathogenesis of Pancreatic, Colorectal, Hepatocellular, and Gallbladder Cancer}},
  url          = {{http://dx.doi.org/10.3390/diseases13030089}},
  doi          = {{10.3390/diseases13030089}},
  volume       = {{13}},
  year         = {{2025}},
}