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The bvFTD phenocopy syndrome : a case study supported by repeated MRI, [18F]FDG-PET and pathological assessment

van Engelen, Marie Paule E. ; Rozemuller, Annemieke J.M. ; Ulugut Erkoyun, Hülya ; Groot, Colin LU ; Fieldhouse, Jay L.P. ; Koene, Ted ; Ossenkoppele, Rik LU ; Gossink, Flora T. ; Krudop, Welmoed A. and Vijverberg, Everard G.B. , et al. (2021) In Neurocase 27(2). p.181-189
Abstract

A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack of decline is a phenocopy of bvFTD (phFTD). Growing evidence suggests that psychological, psychiatric and environmental factors underlie phFTD. We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Behavioral variant frontotemporal dementia, diagnostic distinction of bvFTD and primary psychiatric diseases, misdiagnosis, neuropsychiatry, phenocopy syndrome
in
Neurocase
volume
27
issue
2
pages
9 pages
publisher
Taylor & Francis
external identifiers
  • pmid:33881963
  • scopus:85104788528
ISSN
1355-4794
DOI
10.1080/13554794.2021.1905855
language
English
LU publication?
yes
id
50622424-d297-4e22-a629-4090b6de1cd0
date added to LUP
2021-05-11 15:10:07
date last changed
2024-03-23 04:25:44
@article{50622424-d297-4e22-a629-4090b6de1cd0,
  abstract     = {{<p>A clinical syndrome with neuropsychiatric features of bvFTD without neuroimaging abnormalities and a lack of decline is a phenocopy of bvFTD (phFTD). Growing evidence suggests that psychological, psychiatric and environmental factors underlie phFTD. We describe a patient diagnosed with bvFTD prior to the revision of the diagnostic guidelines of FTD. Repeated neuroimaging was normal and there was no FTD pathology at autopsy, rejecting the diagnosis. We hypothesize on etiological factors that on hindsight might have played a role. This case report contributes to the understanding of phFTD and adds to the sparse literature of the postmortem assessment of phFTD.</p>}},
  author       = {{van Engelen, Marie Paule E. and Rozemuller, Annemieke J.M. and Ulugut Erkoyun, Hülya and Groot, Colin and Fieldhouse, Jay L.P. and Koene, Ted and Ossenkoppele, Rik and Gossink, Flora T. and Krudop, Welmoed A. and Vijverberg, Everard G.B. and Dols, Annemieke and Barkhof, Frederik and Berckel, Bart N.M.Van and Scheltens, Philip and Brain Bank, Netherlands and Pijnenburg, Yolande A.L.}},
  issn         = {{1355-4794}},
  keywords     = {{Behavioral variant frontotemporal dementia; diagnostic distinction of bvFTD and primary psychiatric diseases; misdiagnosis; neuropsychiatry; phenocopy syndrome}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{181--189}},
  publisher    = {{Taylor & Francis}},
  series       = {{Neurocase}},
  title        = {{The bvFTD phenocopy syndrome : a case study supported by repeated MRI, [<sup>18</sup>F]FDG-PET and pathological assessment}},
  url          = {{http://dx.doi.org/10.1080/13554794.2021.1905855}},
  doi          = {{10.1080/13554794.2021.1905855}},
  volume       = {{27}},
  year         = {{2021}},
}