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Expression of caspase-3 predicts prognosis in advanced noncardia gastric cancer

Amptoulach, Sousana LU ; Lazaris, Andreas C.; Giannopoulou, Ioanna; Kavantzas, Nikolaos; Patsouris, Efstratios and Tsavaris, Nikolaos (2015) In Medical Oncology 32(1). p.416-416
Abstract
There is strong evidence that tumor growth is not only a result of uncontrolled cell proliferation but also of decreased apoptosis. Caspase-3 is a member of interleukin-1 beta-converting enzyme which is involved in the induction of apoptosis. Data on the expression of caspase-3 in patients with gastric cancer and its association with patient outcome are somewhat contradictory. We aimed to investigate the potential relation of the expression of caspase-3 protein with response to therapy and overall survival in patients with advanced noncardia gastric cancer. Tumor tissue samples collected from 359 consecutive patients with gastric cancer stage IV were retrospectively analyzed for the expression of caspase-3 in the primary tumor. The DNA... (More)
There is strong evidence that tumor growth is not only a result of uncontrolled cell proliferation but also of decreased apoptosis. Caspase-3 is a member of interleukin-1 beta-converting enzyme which is involved in the induction of apoptosis. Data on the expression of caspase-3 in patients with gastric cancer and its association with patient outcome are somewhat contradictory. We aimed to investigate the potential relation of the expression of caspase-3 protein with response to therapy and overall survival in patients with advanced noncardia gastric cancer. Tumor tissue samples collected from 359 consecutive patients with gastric cancer stage IV were retrospectively analyzed for the expression of caspase-3 in the primary tumor. The DNA apoptotic index assessed by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling method. All patients were followed up until death. Caspase-3 was expressed in 43.5 % of tumors. Caspase-3 expression compared to no expression was related with a higher DNA apoptotic index (p < 0.05). In multivariate analysis, tumor expression of caspase-3 was found to be an independent predictor of poor treatment response and survival (p < 0.05). Expression of caspase-3 in advanced gastric cancer is a predictor of poor response to treatment and survival. Further studies are needed to fully elucidate the prognostic value of caspase-3 expression in these patients. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Caspase-3, TUNEL, Gastric adenocarcinoma, Overall survival, Prognostic, factor, Response to chemotherapy
in
Medical Oncology
volume
32
issue
1
pages
416 - 416
publisher
Humana Press
external identifiers
  • wos:000347775200076
  • scopus:84920191430
ISSN
1559-131X
DOI
10.1007/s12032-014-0416-7
language
English
LU publication?
yes
id
5485acdf-6cf9-4f06-8446-3d3ad59402b5 (old id 5063145)
date added to LUP
2015-03-02 07:10:16
date last changed
2017-01-01 05:36:05
@article{5485acdf-6cf9-4f06-8446-3d3ad59402b5,
  abstract     = {There is strong evidence that tumor growth is not only a result of uncontrolled cell proliferation but also of decreased apoptosis. Caspase-3 is a member of interleukin-1 beta-converting enzyme which is involved in the induction of apoptosis. Data on the expression of caspase-3 in patients with gastric cancer and its association with patient outcome are somewhat contradictory. We aimed to investigate the potential relation of the expression of caspase-3 protein with response to therapy and overall survival in patients with advanced noncardia gastric cancer. Tumor tissue samples collected from 359 consecutive patients with gastric cancer stage IV were retrospectively analyzed for the expression of caspase-3 in the primary tumor. The DNA apoptotic index assessed by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick end labeling method. All patients were followed up until death. Caspase-3 was expressed in 43.5 % of tumors. Caspase-3 expression compared to no expression was related with a higher DNA apoptotic index (p &lt; 0.05). In multivariate analysis, tumor expression of caspase-3 was found to be an independent predictor of poor treatment response and survival (p &lt; 0.05). Expression of caspase-3 in advanced gastric cancer is a predictor of poor response to treatment and survival. Further studies are needed to fully elucidate the prognostic value of caspase-3 expression in these patients.},
  author       = {Amptoulach, Sousana and Lazaris, Andreas C. and Giannopoulou, Ioanna and Kavantzas, Nikolaos and Patsouris, Efstratios and Tsavaris, Nikolaos},
  issn         = {1559-131X},
  keyword      = {Caspase-3,TUNEL,Gastric adenocarcinoma,Overall survival,Prognostic,factor,Response to chemotherapy},
  language     = {eng},
  number       = {1},
  pages        = {416--416},
  publisher    = {Humana Press},
  series       = {Medical Oncology},
  title        = {Expression of caspase-3 predicts prognosis in advanced noncardia gastric cancer},
  url          = {http://dx.doi.org/10.1007/s12032-014-0416-7},
  volume       = {32},
  year         = {2015},
}