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Outcomes of corneal transplantation in Europe : report by the European Cornea and Cell Transplantation Registry

Dunker, Suryan L. ; Armitage, W. John ; Armitage, Margareta ; Brocato, Lucia ; Figueiredo, Francisco C. ; Heemskerk, Martin B.A. ; Hjortdal, Jesper ; Jones, Gary L.A. ; Konijn, Cynthia and Nuijts, Rudy M.M.A. , et al. (2021) In Journal of Cataract and Refractive Surgery 47(6). p.780-785
Abstract

PURPOSE: To analyze real-world graft survival and visual acuity outcomes of corneal transplantation in Europe. SETTING: Corneal clinics in 10 European Union member states, the United Kingdom, and Switzerland. DESIGN: Multinational registry study. METHODS: All corneal transplant procedures registered in the European Cornea and Cell Transplantation Registry (ECCTR) were identified. Graft survival of primary corneal transplants were analyzed using Kaplan-Meier survival curves with log-rank test and Cox regression. Corrected distance visual acuities (CDVAs) are reported at baseline and 2 years postoperatively using the Lundström distribution matrix. RESULTS: A total of 12 913 corneal transplants were identified. Overall, 32-year graft... (More)

PURPOSE: To analyze real-world graft survival and visual acuity outcomes of corneal transplantation in Europe. SETTING: Corneal clinics in 10 European Union member states, the United Kingdom, and Switzerland. DESIGN: Multinational registry study. METHODS: All corneal transplant procedures registered in the European Cornea and Cell Transplantation Registry (ECCTR) were identified. Graft survival of primary corneal transplants were analyzed using Kaplan-Meier survival curves with log-rank test and Cox regression. Corrected distance visual acuities (CDVAs) are reported at baseline and 2 years postoperatively using the Lundström distribution matrix. RESULTS: A total of 12 913 corneal transplants were identified. Overall, 32-year graft survival of corneal transplants was high (89%) but differed between indications, ranging from 98% in keratoconus and 80% for trauma. Overall, CDVA improved postoperatively, but the risk for losing vision ranged from 7% (baseline vision ≤0.1 Snellen) to 58% (baseline vision ≥1.0 Snellen). CONCLUSIONS: This report provides a comprehensive overview of graft survival and visual outcomes of corneal transplantation in Europe. In addition, it provides real-world estimates of outcomes for a variety of indications and surgical techniques to support benchmarking and demonstrates the relationship between baseline and postoperative vision.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cataract and Refractive Surgery
volume
47
issue
6
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85107087190
  • pmid:33278237
ISSN
1873-4502
DOI
10.1097/j.jcrs.0000000000000520
language
English
LU publication?
yes
id
5068ee29-b70f-4859-92e6-5002ae3387a7
date added to LUP
2021-06-22 16:00:06
date last changed
2024-04-20 07:47:13
@article{5068ee29-b70f-4859-92e6-5002ae3387a7,
  abstract     = {{<p>PURPOSE: To analyze real-world graft survival and visual acuity outcomes of corneal transplantation in Europe. SETTING: Corneal clinics in 10 European Union member states, the United Kingdom, and Switzerland. DESIGN: Multinational registry study. METHODS: All corneal transplant procedures registered in the European Cornea and Cell Transplantation Registry (ECCTR) were identified. Graft survival of primary corneal transplants were analyzed using Kaplan-Meier survival curves with log-rank test and Cox regression. Corrected distance visual acuities (CDVAs) are reported at baseline and 2 years postoperatively using the Lundström distribution matrix. RESULTS: A total of 12 913 corneal transplants were identified. Overall, 32-year graft survival of corneal transplants was high (89%) but differed between indications, ranging from 98% in keratoconus and 80% for trauma. Overall, CDVA improved postoperatively, but the risk for losing vision ranged from 7% (baseline vision ≤0.1 Snellen) to 58% (baseline vision ≥1.0 Snellen). CONCLUSIONS: This report provides a comprehensive overview of graft survival and visual outcomes of corneal transplantation in Europe. In addition, it provides real-world estimates of outcomes for a variety of indications and surgical techniques to support benchmarking and demonstrates the relationship between baseline and postoperative vision.</p>}},
  author       = {{Dunker, Suryan L. and Armitage, W. John and Armitage, Margareta and Brocato, Lucia and Figueiredo, Francisco C. and Heemskerk, Martin B.A. and Hjortdal, Jesper and Jones, Gary L.A. and Konijn, Cynthia and Nuijts, Rudy M.M.A. and Lundström, Mats and Dickman, Mor M.}},
  issn         = {{1873-4502}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{6}},
  pages        = {{780--785}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Cataract and Refractive Surgery}},
  title        = {{Outcomes of corneal transplantation in Europe : report by the European Cornea and Cell Transplantation Registry}},
  url          = {{http://dx.doi.org/10.1097/j.jcrs.0000000000000520}},
  doi          = {{10.1097/j.jcrs.0000000000000520}},
  volume       = {{47}},
  year         = {{2021}},
}