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Familial clustering of unexplained heart failure – A Danish nationwide cohort study

Glinge, Charlotte ; Rossetti, Sara ; Oestergaard, Louise Bruun ; Stampe, Niels Kjær ; Jacobsen, Mia Ravn ; Køber, Lars ; Engstrøm, Thomas LU ; Torp-Pedersen, Christian ; Gislason, Gunnar and Jabbari, Reza , et al. (2024) In International Journal of Cardiology
Abstract

Aims: To determine whether a family history of unexplained heart failure (HF) in first-degree relatives (children or sibling) increases the rate of unexplained HF. Methods and results: Using Danish nationwide registry data (1978–2017), we identified patients (probands) diagnosed with first unexplained HF (HF without any known comorbidities) in Denmark, and their first-degree relatives. All first-degree relatives were followed from the HF date of the proband and until an event of unexplained HF, exclusion diagnosis, death, emigration, or study end, whichever occurred first. Using the general population as a reference, we calculated adjusted standardized incidence ratios (SIR) of unexplained HF in the three groups of relatives using... (More)

Aims: To determine whether a family history of unexplained heart failure (HF) in first-degree relatives (children or sibling) increases the rate of unexplained HF. Methods and results: Using Danish nationwide registry data (1978–2017), we identified patients (probands) diagnosed with first unexplained HF (HF without any known comorbidities) in Denmark, and their first-degree relatives. All first-degree relatives were followed from the HF date of the proband and until an event of unexplained HF, exclusion diagnosis, death, emigration, or study end, whichever occurred first. Using the general population as a reference, we calculated adjusted standardized incidence ratios (SIR) of unexplained HF in the three groups of relatives using Poisson regression models. We identified 55,110 first-degree relatives to individuals previously diagnosed with unexplained HF. Having a family history was associated with a significantly increased unexplained HF rate of 2.59 (95%CI 2.29–2.93). The estimate was higher among siblings (SIR 6.67 [95%CI 4.69–9.48]). Noteworthy, the rate of HF increased for all first-degree relatives when the proband was diagnosed with HF in a young age (≤50 years, SIR of 7.23 [95%CI 5.40–9.68]) and having >1 proband (SIR of 5.28 [95%CI 2.75–10.14]). The highest estimate of HF was observed if the proband was ≤40 years at diagnosis (13.17 [95%CI 8.90–19.49]. Conclusion: A family history of unexplained HF was associated with a two-fold increased rate of unexplained HF among first-degree relatives. The relative rate was increased when the proband was diagnosed at a young age. These data suggest that screening families of unexplained HF with onset below 50 years is indicated.

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organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Family aggregation, Family history, First-degree relative, Unexplained heart failure
in
International Journal of Cardiology
publisher
Elsevier
external identifiers
  • pmid:38583593
  • scopus:85190715258
ISSN
0167-5273
DOI
10.1016/j.ijcard.2024.132028
language
English
LU publication?
yes
id
5081b0c4-9469-490c-8550-30e07a8a4cd2
date added to LUP
2024-04-30 10:13:09
date last changed
2024-05-14 11:28:20
@article{5081b0c4-9469-490c-8550-30e07a8a4cd2,
  abstract     = {{<p>Aims: To determine whether a family history of unexplained heart failure (HF) in first-degree relatives (children or sibling) increases the rate of unexplained HF. Methods and results: Using Danish nationwide registry data (1978–2017), we identified patients (probands) diagnosed with first unexplained HF (HF without any known comorbidities) in Denmark, and their first-degree relatives. All first-degree relatives were followed from the HF date of the proband and until an event of unexplained HF, exclusion diagnosis, death, emigration, or study end, whichever occurred first. Using the general population as a reference, we calculated adjusted standardized incidence ratios (SIR) of unexplained HF in the three groups of relatives using Poisson regression models. We identified 55,110 first-degree relatives to individuals previously diagnosed with unexplained HF. Having a family history was associated with a significantly increased unexplained HF rate of 2.59 (95%CI 2.29–2.93). The estimate was higher among siblings (SIR 6.67 [95%CI 4.69–9.48]). Noteworthy, the rate of HF increased for all first-degree relatives when the proband was diagnosed with HF in a young age (≤50 years, SIR of 7.23 [95%CI 5.40–9.68]) and having &gt;1 proband (SIR of 5.28 [95%CI 2.75–10.14]). The highest estimate of HF was observed if the proband was ≤40 years at diagnosis (13.17 [95%CI 8.90–19.49]. Conclusion: A family history of unexplained HF was associated with a two-fold increased rate of unexplained HF among first-degree relatives. The relative rate was increased when the proband was diagnosed at a young age. These data suggest that screening families of unexplained HF with onset below 50 years is indicated.</p>}},
  author       = {{Glinge, Charlotte and Rossetti, Sara and Oestergaard, Louise Bruun and Stampe, Niels Kjær and Jacobsen, Mia Ravn and Køber, Lars and Engstrøm, Thomas and Torp-Pedersen, Christian and Gislason, Gunnar and Jabbari, Reza and Tfelt-Hansen, Jacob}},
  issn         = {{0167-5273}},
  keywords     = {{Family aggregation; Family history; First-degree relative; Unexplained heart failure}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Cardiology}},
  title        = {{Familial clustering of unexplained heart failure – A Danish nationwide cohort study}},
  url          = {{http://dx.doi.org/10.1016/j.ijcard.2024.132028}},
  doi          = {{10.1016/j.ijcard.2024.132028}},
  year         = {{2024}},
}